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In addition, gap junctions may also provide alternative neuronal pathways. However, because they are small and especially difficult to image, gap junctions are often ignored in large-scale 3D reconstructions. Here, we reconstruct gap junctions between photoreceptors in the mouse retina using serial blockface-scanning electron microscopy, focused ion beam-scanning electron microscopy, and confocal microscopy for the gap junction protein Cx36. An exuberant spray of fine telodendria extends from each cone pedicle (including blue cones) to contact 40\u201350 nearby rod spherules at sites of Cx36 labeling, with approximately 50 Cx36 clusters per cone pedicle and 2\u20133 per rod spherule. We were unable to detect rod\/rod or cone\/cone coupling. Thus, rod\/cone coupling accounts for nearly all gap junctions between photoreceptors. We estimate a mean of 86 Cx36 channels per rod\/cone pair, which may provide a maximum conductance of ~1200 pS, if all gap junction channels were open. This is comparable to the maximum conductance previously measured between rod\/cone pairs in the presence of a dopamine antagonist to activate Cx36, suggesting that the open probability of gap junction channels can approach 100% under certain conditions.<\/jats:p>","DOI":"10.7554\/elife.73039","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T07:15:38Z","timestamp":1650957338000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.73039","source":"Crossref","is-referenced-by-count":36,"title":["Analysis of rod\/cone gap junctions from the reconstruction of mouse photoreceptor terminals"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6922-573X","authenticated-orcid":true,"given":"Munenori","family":"Ishibashi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03gds6c39","id-type":"ROR","asserted-by":"publisher"}],"name":"Richard Ruiz Department of Ophthalmology and Visual Science, McGovern Medical 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