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The cytokine interferon gamma (IFN\u03b3) is induced during infection and is critical for restricting\n                    <jats:italic>T. gondii<\/jats:italic>\n                    growth in human cells. Growth restriction is presumed to be due to the induction of interferon-stimulated genes (ISGs) that are upregulated to protect the host from infection. Although there are hundreds of ISGs induced by IFN\u03b3, their individual roles in restricting parasite growth in human cells remain somewhat elusive. To address this deficiency, we screened a library of 414 IFN\u03b3 induced ISGs to identify factors that impact\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection in human cells. In addition to IRF1, which likely acts through the induction of numerous downstream genes, we identified RARRES3 as a single factor that restricts\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection by inducing premature egress of the parasite in multiple human cell lines. Overall, while we successfully identified a novel IFN\u03b3 induced factor restricting\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection, the limited number of ISGs capable of restricting\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection when individually expressed suggests that IFN\u03b3-mediated immunity to\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection is a complex, multifactorial process.\n                  <\/jats:p>","DOI":"10.7554\/elife.73137","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T12:00:36Z","timestamp":1638792036000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.73137","source":"Crossref","is-referenced-by-count":24,"title":["Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection"],"prefix":"10.7554","volume":"10","author":[{"given":"Nicholas","family":"Rinkenberger","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology, Washington University in St. Louis","place":["St Louis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Southwestern","place":["Dallas, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit K","family":"Matta","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University in St. Louis","place":["St Louis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-6800","authenticated-orcid":true,"given":"John W","family":"Schoggins","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Southwestern","place":["Dallas, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-3853","authenticated-orcid":true,"given":"Neal M","family":"Alto","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Southwestern","place":["Dallas, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-0285","authenticated-orcid":true,"given":"L David","family":"Sibley","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University in St. Louis","place":["St Louis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/s41564-020-0701-5","article-title":"Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol","volume":"5","author":"Abrams","year":"2020","journal-title":"Nature Microbiology"},{"key":"bib2","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.4049\/jimmunol.144.7.2725","article-title":"Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. 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