{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:15Z","timestamp":1792035915270,"version":"4.4.0"},"reference-count":72,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD087360"],"award-info":[{"award-number":["R01HD087360"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 HD093425"],"award-info":[{"award-number":["F32 HD093425"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99HD101682"],"award-info":[{"award-number":["K99HD101682"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD104317"],"award-info":[{"award-number":["R01 HD104317"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wheeler Foundation"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,9,13]]},"abstract":"<jats:p>\n                    The diaphragm is a domed muscle between the thorax and abdomen essential for breathing in mammals. Diaphragm development requires the coordinated development of muscle, connective tissue, and nerve, which are derived from different embryonic sources. Defects in diaphragm development cause the common and often lethal birth defect, congenital diaphragmatic hernias (CDH). HGF\/MET signaling is required for diaphragm muscularization, but the source of HGF and the specific functions of this pathway in muscle progenitors and effects on phrenic nerve have not been explicitly tested. Using conditional mutagenesis in mice and pharmacological inhibition of MET, we demonstrate that the pleuroperitoneal folds (PPFs), transient embryonic structures that give rise to the connective tissue in the diaphragm, are the source of HGF critical for diaphragm muscularization. PPF-derived HGF is directly required for recruitment of MET+ muscle progenitors to the diaphragm and indirectly (via its effect on muscle development) required for phrenic nerve primary branching. In addition, HGF is continuously required for maintenance and motility of the pool of progenitors to enable full muscularization. Localization of HGF at the diaphragm\u2019s leading edges directs dorsal and ventral expansion of muscle and regulates its overall size and shape. Surprisingly, large muscleless regions in\n                    <jats:italic>HGF<\/jats:italic>\n                    and\n                    <jats:italic>Met<\/jats:italic>\n                    mutants do not lead to hernias. While these regions are likely more susceptible to CDH, muscle loss is not sufficient to cause CDH.\n                  <\/jats:p>","DOI":"10.7554\/elife.74592","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T09:15:28Z","timestamp":1663146928000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.74592","source":"Crossref","is-referenced-by-count":15,"title":["Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-612X","authenticated-orcid":true,"given":"Elizabeth M","family":"Sefton","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Human Genetics, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirialys","family":"Gallardo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Human Genetics, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E","family":"Tobin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Human Genetics, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany C","family":"Collins","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Human Genetics, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary P","family":"Colasanto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Human Genetics, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson J","family":"Merrell","sequence":"additional","affiliation":[{"name":"Ambys Medicines","place":["South San Francisco, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-4463","authenticated-orcid":true,"given":"Gabrielle","family":"Kardon","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Human Genetics, University of Utah","place":["Salt Lake City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2350\/11-05-1041-OA.1","article-title":"Congenital diaphragmatic defects: proposal for a new classification based on observations in 234 patients","volume":"15","author":"Ackerman","year":"2012","journal-title":"Pediatric and Developmental Pathology"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1186\/s40851-018-0094-y","article-title":"Stepwise participation of HGF\/Met signaling in the development of migratory muscle precursors during vertebrate evolution","volume":"4","author":"Adachi","year":"2018","journal-title":"Zoological Letters"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/(SICI)1096-9861(19970616)382:4<469::AID-CNE4>3.0.CO;2-0","article-title":"Development of phrenic motoneuron morphology in the fetal rat","volume":"382","author":"Allan","year":"1997","journal-title":"The Journal of Comparative Neurology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/(SICI)1096-9861(19970616)382:4<459::AID-CNE3>3.0.CO;2-1","article-title":"Embryogenesis of the phrenic nerve and diaphragm in the fetal rat","volume":"382","author":"Allan","year":"1997","journal-title":"The Journal of Comparative Neurology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/cne.10503","article-title":"Embryological origins and development of the rat diaphragm","volume":"455","author":"Babiuk","year":"2003","journal-title":"The Journal of Comparative Neurology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/nrm1261","article-title":"Met, metastasis, motility and more","volume":"4","author":"Birchmeier","year":"2003","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/376768a0","article-title":"Essential role for the c-Met receptor in the migration of myogenic precursor cells into the limb bud","volume":"376","author":"Bladt","year":"1995","journal-title":"Nature"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ydbio.2020.07.013","article-title":"Cell culture system to assay candidate genes and molecular pathways implicated in congenital diaphragmatic hernias","volume":"467","author":"Bogenschutz","year":"2020","journal-title":"Developmental Biology"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.037","article-title":"Snapshot: neuromuscular junction","volume":"144","author":"Burden","year":"2011","journal-title":"Cell"},{"key":"bib10","volume-title":"The Respiratory Muscles: Mechanics and Neural Control","author":"Campbell","year":"1970"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-014-0056-6","article-title":"Plasticity versus specificity in RTK signalling modalities for distinct biological outcomes in motor neurons","volume":"12","author":"Caruso","year":"2014","journal-title":"BMC Biology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1242\/dev.127.8.1751","article-title":"The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons","volume":"127","author":"Caton","year":"2000","journal-title":"Development"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1242\/dev.163014","article-title":"Niche-mediated BMP\/Smad signaling regulates lung alveolar stem cell proliferation and differentiation","volume":"145","author":"Chung","year":"2018","journal-title":"Development"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"e356","DOI":"10.1542\/peds.2004-2845","article-title":"Outcomes of congenital diaphragmatic hernia: a population-based study in Western Australia","volume":"116","author":"Colvin","year":"2005","journal-title":"Pediatrics"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/nature02051","article-title":"Motor neuron columnar fate imposed by sequential phases of hox-c activity","volume":"425","author":"Dasen","year":"2003","journal-title":"Nature"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.cell.2005.09.009","article-title":"A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity","volume":"123","author":"Dasen","year":"2005","journal-title":"Cell"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.cell.2008.06.019","article-title":"Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FOXP1","volume":"134","author":"Dasen","year":"2008","journal-title":"Cell"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1242\/dev.126.8.1621","article-title":"The role of SF\/HGF and c-Met in the development of skeletal muscle","volume":"126","author":"Dietrich","year":"1999","journal-title":"Development"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/s0896-6273(00)80247-0","article-title":"Hepatocyte growth factor\/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons","volume":"17","author":"Ebens","year":"1996","journal-title":"Neuron"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ydbio.2005.02.002","article-title":"Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives","volume":"280","author":"Engleka","year":"2005","journal-title":"Developmental Biology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"4857","DOI":"10.1242\/dev.01374","article-title":"Met and HGF signaling controls hypaxial muscle and lateral line development in the zebrafish","volume":"131","author":"Haines","year":"2004","journal-title":"Development"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2004734","article-title":"Tissue-Specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis","volume":"16","author":"Helmbacher","year":"2018","journal-title":"PLOS Biology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/joa.12037","article-title":"A new scenario of the evolutionary derivation of the mammalian diaphragm from shoulder muscles","volume":"222","author":"Hirasawa","year":"2013","journal-title":"Journal of Anatomy"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/dgd.12243","article-title":"Expansion of the neck reconstituted the shoulder-diaphragm in amniote evolution","volume":"58","author":"Hirasawa","year":"2016","journal-title":"Development, Growth & Differentiation"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1073\/pnas.0306068101","article-title":"Hepatocyte growth factor\/c-met signaling pathway is required for efficient liver regeneration and repair","volume":"101","author":"Huh","year":"2004","journal-title":"PNAS"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1101\/gad.1769009","article-title":"Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-catenin","volume":"23","author":"Hutcheson","year":"2009","journal-title":"Genes & Development"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/s0095-5108(18)30199-4","article-title":"Congenital diaphragmatic hernia. A historical review","volume":"23","author":"Irish","year":"1996","journal-title":"Clinics in Perinatology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.devcel.2020.03.017","article-title":"Retinoic acid organizes the zebrafish vagus motor topographic MAP via spatiotemporal coordination of HGF\/Met signaling","volume":"53","author":"Isabella","year":"2020","journal-title":"Developmental Cell"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1152\/jappl.1991.70.4.1431","article-title":"Fetal breathing and development of control of breathing","volume":"70","author":"Jansen","year":"1991","journal-title":"Journal of Applied Physiology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.neuron.2010.08.008","article-title":"Global control of motor neuron topography mediated by the repressive actions of a single Hox gene","volume":"67","author":"Jung","year":"2010","journal-title":"Neuron"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1242\/dmm.028365","article-title":"Congenital diaphragmatic hernias: from genes to mechanisms to therapies","volume":"10","author":"Kardon","year":"2017","journal-title":"Disease Models & Mechanisms"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1101\/gad.1243904","article-title":"Pax3: FKHR interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin","volume":"18","author":"Keller","year":"2004","journal-title":"Genes & Development"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"11144","DOI":"10.1523\/JNEUROSCI.2198-11.2011","article-title":"Pool-specific regulation of motor neuron survival by neurotrophic support","volume":"31","author":"Lamballe","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nn2053","article-title":"Retrograde regulation of motoneuron differentiation by muscle beta-catenin","volume":"11","author":"Li","year":"2008","journal-title":"Nature Neuroscience"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/gene.10092","article-title":"Expression of Cre recombinase in the developing mouse limb bud driven by a prxl enhancer","volume":"33","author":"Logan","year":"2002","journal-title":"Genesis"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"12450","DOI":"10.1073\/pnas.1412509111","article-title":"Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics","volume":"111","author":"Longoni","year":"2014","journal-title":"PNAS"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/s0092-8674(00)81372-0","article-title":"Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development","volume":"87","author":"Maina","year":"1996","journal-title":"Cell"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/6310","article-title":"Hepatocyte growth factor, a versatile signal for developing neurons","volume":"2","author":"Maina","year":"1999","journal-title":"Nature Neuroscience"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1111\/febs.12274","article-title":"Development of the diaphragm -- a skeletal muscle essential for mammalian respiration","volume":"280","author":"Merrell","year":"2013","journal-title":"The FEBS Journal"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/ng.3250","article-title":"Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias","volume":"47","author":"Merrell","year":"2015","journal-title":"Nature Genetics"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1242\/dev.064162","article-title":"Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration","volume":"138","author":"Murphy","year":"2011","journal-title":"Development"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.stemcr.2014.06.019","article-title":"Transiently active Wnt\/\u03b2-catenin signaling is not required but must be silenced for stem cell function during muscle regeneration","volume":"3","author":"Murphy","year":"2014","journal-title":"Stem Cell Reports"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent CRE reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"bib44","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00022","article-title":"Non-Myogenic contribution to muscle development and homeostasis: the role of connective tissues","volume":"5","author":"Nassari","year":"2017","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/dgd.12591","article-title":"Involvement of HGF\/Met signaling in appendicular muscle development in cartilaginous fish","volume":"61","author":"Okamoto","year":"2019","journal-title":"Development, Growth & Differentiation"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1177\/1758834011422556","article-title":"An overview of the c-Met signaling pathway","volume":"3","author":"Organ","year":"2011","journal-title":"Therapeutic Advances in Medical Oncology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.resp.2010.01.004","article-title":"The evolutionary origin of the mammalian diaphragm","volume":"171","author":"Perry","year":"2010","journal-title":"Respiratory Physiology & Neurobiology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/dvg.22050","article-title":"Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics","volume":"50","author":"Pham","year":"2012","journal-title":"Genesis"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1089\/dna.2004.23.592","article-title":"Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration","volume":"23","author":"Phaneuf","year":"2004","journal-title":"DNA and Cell Biology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1038\/nn.3242","article-title":"Sustained hox5 gene activity is required for respiratory motor neuron development","volume":"15","author":"Philippidou","year":"2012","journal-title":"Nature Neuroscience"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/ajmg.c.30126","article-title":"Overview of epidemiology, genetics, birth defects, and chromosome abnormalities associated with CDH","volume":"145C","author":"Pober","year":"2007","journal-title":"American Journal of Medical Genetics. Part C, Seminars in Medical Genetics"},{"key":"bib52","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-013-9469-8","article-title":"Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei","volume":"24","author":"Prigge","year":"2013","journal-title":"Mammalian Genome"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.jpedsurg.2010.09.047","article-title":"Costs of congenital diaphragmatic hernia repair in the United states-extracorporeal membrane oxygenation foots the bill","volume":"46","author":"Raval","year":"2011","journal-title":"Journal of Pediatric Surgery"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarizing activity of the ZPA","volume":"75","author":"Riddle","year":"1993","journal-title":"Cell"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.neuron.2008.06.025","article-title":"Coordinated actions of the forkhead protein FOXP1 and Hox proteins in the columnar organization of spinal motor neurons","volume":"59","author":"Rousso","year":"2008","journal-title":"Neuron"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nature Protocols"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1021\/jm801586s","article-title":"Discovery of N- (4- (2-amino-3-chloropyridin-4-yloxy) -3-fluorophenyl) -4-ethoxy-1- (4-fluorophenyl) -2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily","volume":"52","author":"Schroeder","year":"2009","journal-title":"Journal of Medicinal Chemistry"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ydbio.2018.04.010","article-title":"Developmental origin and morphogenesis of the diaphragm, an essential mammalian muscle","volume":"440","author":"Sefton","year":"2018","journal-title":"Developmental Biology"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/bs.ctdb.2018.12.004","article-title":"Connecting muscle development, birth defects, and evolution: an essential role for muscle connective tissue","volume":"132","author":"Sefton","year":"2019","journal-title":"Current Topics in Developmental Biology"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1083\/jcb.123.1.223","article-title":"Scatter factor\/hepatocyte growth factor and its receptor, the c-Met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development","volume":"123","author":"Sonnenberg","year":"1993","journal-title":"The Journal of Cell Biology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 CRE reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nature Genetics"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s00383-016-3944-8","article-title":"Decreased expression of hepatocyte growth factor in the nitrofen model of congenital diaphragmatic hernia","volume":"32","author":"Takahashi","year":"2016","journal-title":"Pediatric Surgery International"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/gene.10030","article-title":"A cre\/loxp-deleter transgenic line in mouse strain 129S1\/svimj","volume":"32","author":"Tang","year":"2002","journal-title":"Genesis"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: an open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/tera.1420460605","article-title":"A population-based study of congenital diaphragmatic hernia","volume":"46","author":"Torfs","year":"1992","journal-title":"Teratology"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"5872","DOI":"10.1523\/JNEUROSCI.0386-06.2006","article-title":"Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta","volume":"26","author":"Uetani","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1006\/geno.1993.1333","article-title":"The splotch-delayed (SPD) mouse mutant carries a point mutation within the paired box of the Pax-3 gene","volume":"17","author":"Vogan","year":"1993","journal-title":"Genomics"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1109\/TVCG.2009.118","article-title":"An interactive visualization tool for multi-channel confocal microscopy data in neurobiology research","volume":"15","author":"Wan","year":"2009","journal-title":"IEEE Transactions on Visualization and Computer Graphics"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1523\/JNEUROSCI.23-12-05161.2003","article-title":"Aberrant development of motor axons and neuromuscular synapses in myod-null mice","volume":"23","author":"Wang","year":"2003","journal-title":"The Journal of Neuroscience"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1242\/dev.124.15.2903","article-title":"Hepatocyte growth factor (HGF\/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons","volume":"124","author":"Yamamoto","year":"1997","journal-title":"Development"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nature11348","article-title":"Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses","volume":"489","author":"Yumoto","year":"2012","journal-title":"Nature"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.stem.2010.04.002","article-title":"CNS-resident glial progenitor\/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination","volume":"6","author":"Zawadzka","year":"2010","journal-title":"Cell Stem Cell"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/74592\/elife-74592-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/74592\/elife-74592-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/74592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:11:13Z","timestamp":1697058673000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/74592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":72,"alternative-id":["10.7554\/eLife.74592"],"URL":"https:\/\/doi.org\/10.7554\/elife.74592","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.29.462475","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.74592.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.74592.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.74592.sa1","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e74592"}}