{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:22:39Z","timestamp":1787822559285,"version":"build-2784847793"},"reference-count":75,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["Grant 249988"],"award-info":[{"award-number":["Grant 249988"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["Grant 302326"],"award-info":[{"award-number":["Grant 302326"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013842","name":"Letten Foundation","doi-asserted-by":"crossref","award":["Research support"],"award-info":[{"award-number":["Research support"]}],"id":[{"id":"10.13039\/501100013842","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021720","name":"Olav Thon Stiftelsen","doi-asserted-by":"crossref","award":["Olav Thon Award"],"award-info":[{"award-number":["Olav Thon Award"]}],"id":[{"id":"10.13039\/501100021720","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["Grant 2016070"],"award-info":[{"award-number":["Grant 2016070"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["Medical Student Research Program"],"award-info":[{"award-number":["Medical Student Research Program"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["2020039"],"award-info":[{"award-number":["2020039"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["Grant 271555\/F20"],"award-info":[{"award-number":["Grant 271555\/F20"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,6,29]]},"abstract":"<jats:p>\n                    Increased astrocytic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling has been shown in Alzheimer\u2019s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling in such mice. Here, we employ an event-based algorithm to assess astrocytic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals in the neocortex of awake-behaving tg-ArcSwe mice and non-transgenic wildtype littermates while monitoring pupil responses and behavior. We demonstrate an attenuated astrocytic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    response to locomotion and an uncoupling of pupil responses and astrocytic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling in 15-month-old plaque-bearing mice. Using the genetically encoded fluorescent norepinephrine sensor GRAB\n                    <jats:sub>NE<\/jats:sub>\n                    , we demonstrate a reduced norepinephrine signaling during spontaneous running and startle responses in the transgenic mice, providing a possible mechanistic underpinning of the observed reduced astrocytic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    responses. Our data points to a dysfunction in the norepinephrine\u2013astrocyte Ca\n                    <jats:sup>2+<\/jats:sup>\n                    activity axis, which may account for some of the cognitive deficits observed in Alzheimer\u2019s disease.\n                  <\/jats:p>","DOI":"10.7554\/elife.75055","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T03:15:17Z","timestamp":1656558917000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.75055","source":"Crossref","is-referenced-by-count":48,"title":["Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer\u2019s disease transgenic mice"],"prefix":"10.7554","volume":"11","author":[{"given":"Knut Sindre","family":"\u00c5bj\u00f8rsbr\u00e5ten","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"GliaLab at the Letten Centre, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gry HE Syverstad","family":"Skaaraas","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Cunen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Statistics and Data Science group, Department of Mathematics, Faculty of Mathematics and Natural Sciences, University of Oslo","place":["Oslo, Norway"]},{"id":[{"id":"https:\/\/ror.org\/02gm7te43","id-type":"ROR","asserted-by":"publisher"}],"name":"Norwegian Computing Center","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M","family":"Bj\u00f8rnstad","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"GliaLab at the Letten Centre, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin M Gullestad","family":"Binder","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"GliaLab at the Letten Centre, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo","place":["Oslo, 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Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars NG","family":"Nilsson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00j9c2840","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, University of Oslo and Oslo University Hospital","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyas B","family":"Rao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannan","family":"Tang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"GliaLab at the Letten Centre, Division of Anatomy, Department of Molecular 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