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However, its clinical application remains controversial, hampered by two major factors: (1) Many of the CNS injury sites, such as the optic nerve (ON), are deeply buried, preventing access for local TH. The alternative is to apply TH systemically, which significantly limits the applicable temperature range. (2) Even with possible access for \u2018local refrigeration\u2019, cold-induced cellular damage offsets the benefit of TH. Here we present a clinically translatable model of traumatic optic neuropathy (TON) by applying clinical trans-nasal endoscopic surgery to goats and non-human primates. This model faithfully recapitulates clinical features of TON such as the injury site (pre-chiasmatic ON), the spatiotemporal pattern of neural degeneration, and the accessibility of local treatments with large operating space. We also developed a computer program to simplify the endoscopic procedure and expand this model to other large animal species. Moreover, applying a cold-protective treatment, inspired by our previous hibernation research, enables us to deliver deep hypothermia (4 \u00b0C) locally to mitigate inflammation and metabolic stress (indicated by the transcriptomic changes after injury) without cold-induced cellular damage, and confers prominent neuroprotection both structurally and functionally. Intriguingly, neither treatment alone was effective, demonstrating that in situ deep hypothermia combined with cold protection constitutes a breakthrough for TH as a therapy for TON and other CNS traumas.<\/jats:p>","DOI":"10.7554\/elife.75070","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T08:00:40Z","timestamp":1648627240000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.75070","source":"Crossref","is-referenced-by-count":11,"title":["Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9060-602X","authenticated-orcid":true,"given":"Yikui","family":"Zhang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rd5t069","id-type":"ROR","asserted-by":"publisher"}],"name":"The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University","place":["Wenzhou, 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