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If not properly treated these infections cause complications and exacerbate antimicrobial resistance. Catheter use elicits bladder inflammation, releasing host serum proteins, including fibrinogen (Fg), into the bladder, which deposit on the urinary catheter.\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    uses Fg as a scaffold to bind and persist in the bladder despite antibiotic treatments. Inhibition of Fg\u2013pathogen interaction significantly reduces infection. Here, we show deposited Fg is advantageous for uropathogens\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    , and\n                    <jats:italic>C. albicans<\/jats:italic>\n                    , suggesting that targeting catheter protein deposition may reduce colonization creating an effective intervention for catheter-associated urinary tract infections (CAUTIs). In a mouse model of CAUTI, host-protein deposition was reduced, using liquid-infused silicone catheters, resulting in decreased colonization on catheters, in bladders, and dissemination in vivo. Furthermore, proteomics revealed a significant decrease in deposition of host-secreted proteins on liquid-infused catheter surfaces. Our findings suggest targeting microbial-binding scaffolds may be an effective antibiotic-sparing intervention for use against CAUTIs and other medical device infections.\n                  <\/jats:p>","DOI":"10.7554\/elife.75798","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T13:15:12Z","timestamp":1648300512000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.75798","source":"Crossref","is-referenced-by-count":72,"title":["Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections"],"prefix":"10.7554","volume":"11","author":[{"given":"Marissa Jeme","family":"Andersen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Sciences, College of Science, University of Notre Dame","place":["Notre Dame, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChunKi","family":"Fong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01adr0w49","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemical and Biomedical Engineering, College of Engineering, University of Maine","place":["Orono, United States"]},{"id":[{"id":"https:\/\/ror.org\/01adr0w49","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate School of Biomedical Science and Engineering, University of Maine","place":["Orono, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa Ann","family":"La Bella","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Sciences, College of Science, University of Notre Dame","place":["Notre Dame, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Jesus","family":"Molina","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Sciences, College of Science, University of Notre Dame","place":["Notre Dame, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Molesan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Sciences, College of Science, University of Notre Dame","place":["Notre Dame, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M","family":"Champion","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemistry and Biochemistry, College of Science, University of Notre Dame","place":["Notre Dame, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-6642","authenticated-orcid":true,"given":"Caitlin","family":"Howell","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01adr0w49","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemical and Biomedical Engineering, College of Engineering, University of Maine","place":["Orono, United States"]},{"id":[{"id":"https:\/\/ror.org\/01adr0w49","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate School of Biomedical Science and Engineering, University of Maine","place":["Orono, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-4246","authenticated-orcid":true,"given":"Ana L","family":"Flores-Mireles","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00mkhxb43","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Sciences, College of Science, University of Notre Dame","place":["Notre Dame, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1021\/pr300813h","article-title":"Characterization of fibrinogen glycosylation and its importance for serum\/plasma N-glycome analysis","volume":"12","author":"Adamczyk","year":"2013","journal-title":"Journal of Proteome Research"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.3390\/coatings10010023","article-title":"Urinary Catheter Coating Modifications: The Race against Catheter-Associated Infections","volume":"10","author":"Andersen","year":"2019","journal-title":"Coatings"},{"key":"bib3","article-title":"Antibiotic resistance threats in the United States","volume-title":"CDC","author":"Antibiotic resistance threats in the United States","year":"2019","unstructured":"Antibiotic resistance threats in the United States. 2019. 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