{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:18:32Z","timestamp":1788448712151,"version":"build-2803163510"},"reference-count":56,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01-AR44731"],"award-info":[{"award-number":["R01-AR44731"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,10,10]]},"abstract":"<jats:p>\n                    Pristane causes chronic peritoneal inflammation resulting in lupus, which in C57BL\/6 mice is complicated by lung microvascular injury and diffuse alveolar hemorrhage (DAH). Mineral oil (MO) also causes inflammation, but not lupus or DAH. Since monocyte depletion prevents DAH, we examined the role of monocytes in the disease. Impaired bone marrow (BM) monocyte egress in\n                    <jats:italic>Ccr2\u2212<\/jats:italic>\n                    \/\u2212 mice abolished DAH, confirming the importance of monocyte recruitment to the lung. Circulating Ly6C\n                    <jats:sup>hi<\/jats:sup>\n                    monocytes from pristane-treated mice exhibited increased annexin-V staining in comparison with MO-treated controls without evidence of apoptosis, suggesting that pristane alters the distribution of phosphatidylserine in the plasma membrane before or shortly after monocyte egress from the BM. Plasma membrane asymmetry also was impaired in Nr4a1-regulated Ly6C\n                    <jats:sup>lo\/\u2212<\/jats:sup>\n                    \u2018patrolling\u2019 monocytes, which are derived from Ly6C\n                    <jats:sup>hi<\/jats:sup>\n                    precursors. Patrolling Ly6C\n                    <jats:sup>lo\/\u2212<\/jats:sup>\n                    monocytes normally promote endothelial repair, but their phenotype was altered in pristane-treated mice. In contrast to MO-treated controls, Nr4a1-regulated Ly6C\n                    <jats:sup>lo\/\u2212<\/jats:sup>\n                    monocytes from pristane-treated mice were CD138\n                    <jats:sup>+<\/jats:sup>\n                    , expressed more TremL4, a protein that amplifies TLR7 signaling, and exuberantly produced TNF\u03b1 in response to TLR7 stimulation. TremL4 expression on these novel CD138\n                    <jats:sup>+<\/jats:sup>\n                    monocytes was regulated by Nr4a1. Thus, monocyte CD138, high TremL4 expression, and annexin-V staining may define an activated\/inflammatory subtype of patrolling monocytes associated with DAH susceptibility. By altering monocyte development, pristane exposure may generate activated Ly6C\n                    <jats:sup>hi<\/jats:sup>\n                    and Ly6C\n                    <jats:sup>lo\/\u2212<\/jats:sup>\n                    monocytes, contributing to lung microvascular endothelial injury and DAH susceptibility.\n                  <\/jats:p>","DOI":"10.7554\/elife.76205","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T02:15:10Z","timestamp":1665454510000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.76205","source":"Crossref","is-referenced-by-count":13,"title":["A novel monocyte differentiation pattern in pristane-induced lupus with diffuse alveolar hemorrhage"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-120X","authenticated-orcid":true,"given":"Shuhong","family":"Han","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Rheumatology, Allergy, & Clinical Immunology, University of Florida","place":["Gainesville, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Zhuang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Rheumatology, Allergy, & Clinical Immunology, University of Florida","place":["Gainesville, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-2098","authenticated-orcid":true,"given":"Rawad Daniel","family":"Arja","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Rheumatology, Allergy, & Clinical Immunology, University of Florida","place":["Gainesville, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-4549","authenticated-orcid":true,"given":"Westley H","family":"Reeves","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Rheumatology, Allergy, & Clinical Immunology, University of Florida","place":["Gainesville, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1177\/0961203320903798","article-title":"Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies","volume":"29","author":"Al-Adhoubi","year":"2020","journal-title":"Lupus"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/labinvest.2011.108","article-title":"Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane","volume":"91","author":"Barker","year":"2011","journal-title":"Laboratory Investigation; a Journal of Technical Methods and Pathology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1016\/j.celrep.2016.05.025","article-title":"Distinct transcriptional programs control cross-priming in classical and monocyte-derived dendritic cells","volume":"15","author":"Brise\u00f1o","year":"2016","journal-title":"Cell Reports"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.cell.2013.03.010","article-title":"Nr4a1-dependent Ly6C (low) monocytes monitor endothelial cells and orchestrate their disposal","volume":"153","author":"Carlin","year":"2013","journal-title":"Cell"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/s41589-020-00688-0","article-title":"Structural and functional consequences of reversible lipid asymmetry in living membranes","volume":"16","author":"Doktorova","year":"2020","journal-title":"Nature Chemical Biology"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43745-y","article-title":"TREML4 mrna expression and polymorphisms in blood leukocytes are associated with atherosclerotic lesion extension in coronary artery disease","volume":"9","author":"Duarte","year":"2019","journal-title":"Scientific Reports"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12597","article-title":"Regulation of monocyte cell fate by blood vessels mediated by Notch signalling","volume":"7","author":"Gamrekelashvili","year":"2016","journal-title":"Nature Communications"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.freeradbiomed.2012.05.026","article-title":"Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis","volume":"53","author":"Gao","year":"2012","journal-title":"Free Radical Biology & Medicine"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1073\/pnas.0915000107","article-title":"Two physically, functionally, and developmentally distinct peritoneal macrophage subsets","volume":"107","author":"Ghosn","year":"2010","journal-title":"PNAS"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nri3671","article-title":"Monocytes and macrophages: developmental pathways and tissue homeostasis","volume":"14","author":"Ginhoux","year":"2014","journal-title":"Nature Reviews. Immunology"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00397","article-title":"TREML4 promotes inflammatory programs in human and murine macrophages and alters atherosclerosis lesion composition in the apolipoprotein E deficient mouse","volume":"11","author":"Gonzalez-Cotto","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.4049\/jimmunol.1700099","article-title":"A novel subset of anti-inflammatory CD138+ macrophages is deficient in mice with experimental lupus","volume":"199","author":"Han","year":"2017","journal-title":"Journal of Immunology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/art.41072","article-title":"Differential responsiveness of monocyte and macrophage subsets to interferon","volume":"72","author":"Han","year":"2020","journal-title":"Arthritis & Rheumatology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/ni.2063","article-title":"The transcription factor Nr4a1 (Nur77) controls bone marrow differentiation and the survival of ly6c- monocytes","volume":"12","author":"Hanna","year":"2011","journal-title":"Nature Immunology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1161\/CIRCRESAHA.111.253377","article-title":"NR4A1 (nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis","volume":"110","author":"Hanna","year":"2012","journal-title":"Circulation Research"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.4049\/jimmunol.182.3.1278","article-title":"A new triggering receptor expressed on myeloid cells (TREM) family member, TREM-like 4, binds to dead cells and is A dnax activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells","volume":"182","author":"Hemmi","year":"2009","journal-title":"Journal of Immunology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/ni.2638","article-title":"Origin of monocytes and macrophages in a committed progenitor","volume":"14","author":"Hettinger","year":"2013","journal-title":"Nature Immunology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"475","DOI":"10.5858\/2001-125-0475-AHARMI","article-title":"Alveolar hemorrhage and renal microangiopathy in systemic lupus erythematosus","volume":"125","author":"Hughson","year":"2001","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235028","article-title":"Comparison of gene expression profiles between human and mouse monocyte subsets","volume":"115","author":"Ingersoll","year":"2010","journal-title":"Blood"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri.2017.28","article-title":"Monocyte differentiation and antigen-presenting functions","volume":"17","author":"Jakubzick","year":"2017","journal-title":"Nature Reviews. Immunology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1083\/jcb.101.3.976","article-title":"Heparan sulfate proteoglycans from mouse mammary epithelial cells: localization on the cell surface with a monoclonal antibody","volume":"101","author":"Jalkanen","year":"1985","journal-title":"The Journal of Cell Biology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"31764","DOI":"10.1074\/jbc.M109.038547","article-title":"A biologically active sequence of the laminin alpha2 large globular 1 domain promotes cell adhesion through syndecan-1 by inducing phosphorylation and membrane localization of protein kinase Cdelta","volume":"284","author":"Jung","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"15070","DOI":"10.1074\/jbc.RA118.002720","article-title":"Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1\u03b1 and affect bone marrow homeostasis in mice and humans","volume":"293","author":"Koenis","year":"2018","journal-title":"The Journal of Biological Chemistry"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/j.1365-2613.2009.00686.x","article-title":"Oxidized laminin-1 induces increased monocyte attachment and expression of ICAM-1 in endothelial cells","volume":"90","author":"Kostidou","year":"2009","journal-title":"International Journal of Experimental Pathology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.4161\/cam.3.2.8207","article-title":"Monocyte attachment to laminin in diabetes mellitus: the role of ATP","volume":"3","author":"Kostidou","year":"2009","journal-title":"Cell Adhesion & Migration"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1172\/JCI125116","article-title":"Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis","volume":"129","author":"Kuriakose","year":"2019","journal-title":"The Journal of Clinical Investigation"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1182\/blood-2008-07-170787","article-title":"Cx3Cr1 is required for monocyte homeostasis and atherogenesis by promoting cell survival","volume":"113","author":"Landsman","year":"2009","journal-title":"Blood"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.2353\/ajpath.2009.090328","article-title":"Type I interferon modulates monocyte recruitment and maturation in chronic inflammation","volume":"175","author":"Lee","year":"2009","journal-title":"The American Journal of Pathology"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129703","article-title":"High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage","volume":"4","author":"Lee","year":"2019","journal-title":"JCI Insight"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-016-0281-2","article-title":"Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation","volume":"14","author":"Loscertales","year":"2016","journal-title":"BMC Biology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/s1074-7613(01)00229-1","article-title":"Rapid secretion of interleukin-1beta by microvesicle shedding","volume":"15","author":"MacKenzie","year":"2001","journal-title":"Immunity"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00007","article-title":"Nr4A receptors differentially regulate NF-\u03baB signaling in myeloid cells","volume":"8","author":"McEvoy","year":"2017","journal-title":"Frontiers in Immunology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.immuni.2017.04.018","article-title":"Genomic characterization of murine monocytes reveals C\/EBP\u03b2 transcription factor dependence of ly6c- cells","volume":"46","author":"Mildner","year":"2017","journal-title":"Immunity"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev-immunol-042617-053119","article-title":"Nonclassical monocytes in health and disease","volume":"37","author":"Narasimhan","year":"2019","journal-title":"Annual Review of Immunology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/s41590-020-0789-z","article-title":"TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis","volume":"21","author":"Nedeva","year":"2020","journal-title":"Nature Immunology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ni.3143","article-title":"The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity","volume":"16","author":"Ramirez-Ortiz","year":"2015","journal-title":"Nature Immunology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.it.2009.06.003","article-title":"Induction of autoimmunity by pristane and other naturally occurring hydrocarbons","volume":"30","author":"Reeves","year":"2009","journal-title":"Trends in Immunology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1006\/excr.1994.1330","article-title":"A novel laminin-binding form of syndecan-1 (cell surface proteoglycan) produced by syndecan-1 cDNA-transfected NIH-3T3 cells","volume":"215","author":"Salmivirta","year":"1994","journal-title":"Experimental Cell Research"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/glycob\/4.3.327","article-title":"Interactions of syndecan-1 and heparin with human collagens","volume":"4","author":"San Antonio","year":"1994","journal-title":"Glycobiology"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11843-0","article-title":"Non-Classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung","volume":"10","author":"Schyns","year":"2019","journal-title":"Nature Communications"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.tcb.2015.08.003","article-title":"An apoptotic \u201c eat me \u201d signal: phosphatidylserine exposure","volume":"25","author":"Segawa","year":"2015","journal-title":"Trends in Cell Biology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nature Immunology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"5129","DOI":"10.4049\/jimmunol.1401051","article-title":"Pristane-induced granulocyte recruitment promotes phenotypic conversion of macrophages and protects against diffuse pulmonary hemorrhage in mac-1 deficiency","volume":"193","author":"Shi","year":"2014","journal-title":"Journal of Immunology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1089\/wound.2014.0555","article-title":"Syndecan-1 and its expanding list of contacts","volume":"4","author":"Stepp","year":"2015","journal-title":"Advances in Wound Care"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.4049\/jimmunol.1500522","article-title":"Differentiation kinetics of blood monocytes and dendritic cells in macaques: insights to understanding human myeloid cell development","volume":"195","author":"Sugimoto","year":"2015","journal-title":"Journal of Immunology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.4049\/jimmunol.172.7.4410","article-title":"Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response","volume":"172","author":"Sunderk\u00f6tter","year":"2004","journal-title":"Journal of Immunology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1172\/JCI28549","article-title":"Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques","volume":"117","author":"Tacke","year":"2007","journal-title":"The Journal of Clinical Investigation"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.immuni.2016.10.011","article-title":"Deleting an Nr4a1 super-enhancer subdomain ablates ly6clow monocytes while preserving macrophage gene function","volume":"45","author":"Thomas","year":"2016","journal-title":"Immunity"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1084\/jem.20061011","article-title":"Monocytes give rise to mucosal, but not splenic, conventional dendritic cells","volume":"204","author":"Varol","year":"2007","journal-title":"The Journal of Experimental Medicine"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1161\/CIRCULATIONAHA.108.823740","article-title":"Functional role of cd11c+ monocytes in atherogenesis associated with hypercholesterolemia","volume":"119","author":"Wu","year":"2009","journal-title":"Circulation"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1161\/ATVBAHA.115.305609","article-title":"Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia","volume":"35","author":"Xu","year":"2015","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1083\/jcb.122.4.941","article-title":"Post-Transcriptional regulation of syndecan-1 expression by cAMP in peritoneal macrophages","volume":"122","author":"Yeaman","year":"1993","journal-title":"The Journal of Cell Biology"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/00005792-199705000-00005","article-title":"Diffuse alveolar hemorrhage and systemic lupus erythematosus. clinical presentation, histology, survival, and outcome","volume":"76","author":"Zamora","year":"1997","journal-title":"Medicine"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1002\/art.40077","article-title":"Pathogenesis of diffuse alveolar hemorrhage in murine lupus","volume":"69","author":"Zhuang","year":"2017","journal-title":"Arthritis & Rheumatology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/76205\/elife-76205-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/76205\/elife-76205-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/76205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:14:37Z","timestamp":1697058877000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/76205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,20]]},"references-count":56,"alternative-id":["10.7554\/eLife.76205"],"URL":"https:\/\/doi.org\/10.7554\/elife.76205","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.01.09.475578","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.76205.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.76205.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.76205.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,20]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e76205"}}