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These studies suggest that IgG effector function contributes to the clearance of autoantibody-Ag complexes, which is harmful in TTP, but beneficial in PF and may provide new therapeutic opportunity.<\/jats:p>","DOI":"10.7554\/elife.76223","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T08:00:53Z","timestamp":1659513653000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.76223","source":"Crossref","is-referenced-by-count":5,"title":["Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-4777","authenticated-orcid":true,"given":"Yanxia","family":"Bi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"publisher"}],"name":"Shanghai Institute of Immunology, Faculty of Basic Medicine; 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