{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:20:36Z","timestamp":1785410436305,"version":"3.56.0"},"reference-count":59,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017540","name":"NHLBI Division of Intramural Research","doi-asserted-by":"crossref","award":["R01 HL155439-01"],"award-info":[{"award-number":["R01 HL155439-01"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"crossref"}]},{"name":"GMS","award":["1P20GM121316-01-A1"],"award-info":[{"award-number":["1P20GM121316-01-A1"]}]},{"name":"Nebraska Stem Cell Research","award":["LB606"],"award-info":[{"award-number":["LB606"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01DK113117-03"],"award-info":[{"award-number":["K01DK113117-03"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,6,6]]},"abstract":"<jats:p>\n                    Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals\u2014involving cooperation between stem cell factor (SCF)\/Kit signaling and other signaling inputs\u2014are required for the increased erythroid precursor activity in anemia. Our prior work revealed that the sterile alpha motif (SAM) domain 14 (\n                    <jats:italic>Samd14<\/jats:italic>\n                    ) gene increases the regenerative capacity of the erythroid system in a mouse genetic model and promotes stress-dependent Kit signaling. However, the mechanism underlying Samd14\u2019s role in stress erythropoiesis is unknown. We identified a protein-protein interaction between Samd14 and the \u03b1- and \u03b2-heterodimers of the F-actin capping protein (CP) complex. Knockdown of the CP \u03b2 subunit increased erythroid maturation in murine ex vivo cultures and decreased colony forming potential of stress erythroid precursors. In a genetic complementation assay for Samd14 activity, our results revealed that the Samd14-CP interaction is a determinant of erythroid precursor cell levels and function. Samd14-CP promotes SCF\/Kit signaling in CD71\n                    <jats:sup>med<\/jats:sup>\n                    spleen erythroid precursors. Given the roles of Kit signaling in hematopoiesis and Samd14 in Kit pathway activation, this mechanism may have pathological implications in acute\/chronic anemia.\n                  <\/jats:p>","DOI":"10.7554\/elife.76497","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T06:15:41Z","timestamp":1655446541000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.76497","source":"Crossref","is-referenced-by-count":14,"title":["Functional requirements for a Samd14-capping protein complex in stress erythropoiesis"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0887-6640","authenticated-orcid":true,"given":"Suhita","family":"Ray","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00thqtb16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center","place":["Omaha, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Chee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00thqtb16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center","place":["Omaha, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Zhou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00thqtb16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center","place":["Omaha, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg A","family":"Schaefer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00thqtb16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center","place":["Omaha, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Naldrett","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mer456","id-type":"ROR","asserted-by":"publisher"}],"name":"Proteomics and Metabolomics Facility, University of Nebraska-Lincoln","place":["Lincoln, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Alvarez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mer456","id-type":"ROR","asserted-by":"publisher"}],"name":"Proteomics and Metabolomics Facility, University of Nebraska-Lincoln","place":["Lincoln, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas T","family":"Woods","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00thqtb16","id-type":"ROR","asserted-by":"publisher"}],"name":"Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center","place":["Omaha, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-625X","authenticated-orcid":true,"given":"Kyle J","family":"Hewitt","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00thqtb16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center","place":["Omaha, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1084\/jem.20031983","article-title":"Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development","volume":"199","author":"Agosti","year":"2004","journal-title":"The Journal of Experimental Medicine"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.exphem.2008.10.009","article-title":"A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis","volume":"37","author":"Agosti","year":"2009","journal-title":"Experimental Hematology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","article-title":"A mechanical checkpoint controls multicellular growth through YAP\/TAZ regulation by actin-processing factors","volume":"154","author":"Aragona","year":"2013","journal-title":"Cell"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.cell.2016.10.042","article-title":"The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease","volume":"167","author":"Astle","year":"2016","journal-title":"Cell"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1101\/gad.13.22.2996","article-title":"The glucocorticoid receptor is required for stress erythropoiesis","volume":"13","author":"Bauer","year":"1999","journal-title":"Genes & Development"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1242\/dev.151423","article-title":"Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond","volume":"145","author":"Bresnick","year":"2018","journal-title":"Development"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1182\/blood.V88.1.75.75","article-title":"Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen","volume":"88","author":"Broudy","year":"1996","journal-title":"Blood"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"19196","DOI":"10.1074\/jbc.M600166200","article-title":"Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein","volume":"281","author":"Bruck","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"36347","DOI":"10.1074\/jbc.M607595200","article-title":"The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein","volume":"281","author":"Canton","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1083\/jcb.105.1.371","article-title":"Cap Z(36\/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle","volume":"105","author":"Casella","year":"1987","journal-title":"The Journal of Cell Biology"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9415","article-title":"CPI motif interaction is necessary for capping protein function in cells","volume":"6","author":"Edwards","year":"2015","journal-title":"Nature Communications"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002197","article-title":"Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA","volume":"7","author":"Fehrmann","year":"2011","journal-title":"PLOS Genetics"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1182\/blood-2010-07-295550","article-title":"HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal","volume":"117","author":"Flygare","year":"2011","journal-title":"Blood"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/328359a0","article-title":"Modulation of spectrin-actin assembly by erythrocyte adducin","volume":"328","author":"Gardner","year":"1987","journal-title":"Nature"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.celrep.2016.06.085","article-title":"Comprehensive Proteomic Analysis of Human Erythropoiesis","volume":"16","author":"Gautier","year":"2016","journal-title":"Cell Reports"},{"key":"bib16","first-page":"452","article-title":"Analysis of the hematopoietic effects of new dominant spotting (W) mutations of the mouse. I. Influence upon hematopoietic stem cells","volume":"11","author":"Geissler","year":"1983","journal-title":"Experimental Hematology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1182\/blood-2007-09-115121","article-title":"Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis","volume":"111","author":"Guti\u00e9rrez","year":"2008","journal-title":"Blood"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1182\/bloodadvances.2019000375","article-title":"Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche","volume":"3","author":"Hao","year":"2019","journal-title":"Blood Advances"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1172\/JCI41291","article-title":"Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors","volume":"120","author":"Harandi","year":"2010","journal-title":"The Journal of Clinical Investigation"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-2141.1972.tb08797.x","article-title":"The response of W-W v and Sl-Sl d anaemic mice to haemopoietic stimuli","volume":"22","author":"Harrison","year":"1972","journal-title":"British Journal of Haematology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nsmb.1792","article-title":"Structural characterization of a capping protein interaction motif defines a family of actin filament regulators","volume":"17","author":"Hernandez-Valladares","year":"2010","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.molcel.2015.05.020","article-title":"Hematopoietic Signaling Mechanism Revealed from a Stem\/Progenitor Cell Cistrome","volume":"59","author":"Hewitt","year":"2015","journal-title":"Molecular Cell"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.devcel.2017.07.009","article-title":"GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia","volume":"42","author":"Hewitt","year":"2017","journal-title":"Developmental Cell"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature15530","article-title":"A perisinusoidal niche for extramedullary haematopoiesis in the spleen","volume":"527","author":"Inra","year":"2015","journal-title":"Nature"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/288455a0","article-title":"An actin-binding protein from Acanthamoeba regulates actin filament polymerization and interactions","volume":"288","author":"Isenberg","year":"1980","journal-title":"Nature"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41313","article-title":"A novel mode of capping protein-regulation by twinfilin","volume":"7","author":"Johnston","year":"2018","journal-title":"eLife"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"13461","DOI":"10.1021\/bi970601b","article-title":"Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin","volume":"36","author":"Kuhlman","year":"1997","journal-title":"Biochemistry"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1126\/science.1256271","article-title":"Chromatin state dynamics during blood formation","volume":"345","author":"Lara-Astiaso","year":"2014","journal-title":"Science"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/nature14326","article-title":"PPAR-\u03b1 and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal","volume":"522","author":"Lee","year":"2015","journal-title":"Nature"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","article-title":"Stem cell factor receptor\/c-Kit: from basic science to clinical implications","volume":"92","author":"Lennartsson","year":"2012","journal-title":"Physiological Reviews"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1182\/blood-2004-02-0703","article-title":"BMP4 and Madh5 regulate the erythroid response to acute anemia","volume":"105","author":"Lenox","year":"2005","journal-title":"Blood"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.exphem.2009.01.004","article-title":"Extramedullary erythropoiesis in the adult liver requires BMP-4\/Smad5-dependent signaling","volume":"37","author":"Lenox","year":"2009","journal-title":"Experimental Hematology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.devcel.2019.01.026","article-title":"Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production","volume":"49","author":"Li","year":"2019","journal-title":"Developmental Cell"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1182\/blood-2005-11-4458","article-title":"Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo","volume":"108","author":"Liu","year":"2006","journal-title":"Blood"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.critrevonc.2004.11.005","article-title":"Role of c-Kit and erythropoietin receptor in erythropoiesis","volume":"54","author":"Munugalavadla","year":"2005","journal-title":"Critical Reviews in Oncology\/Hematology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.ccr.2013.08.011","article-title":"Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7","volume":"24","author":"Nagamachi","year":"2013","journal-title":"Cancer Cell"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.exphem.2020.07.011","article-title":"Stress erythropoiesis: definitions and models for its study","volume":"89","author":"Paulson","year":"2020","journal-title":"Experimental Hematology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1182\/blood-2008-03-147892","article-title":"Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling","volume":"113","author":"Perry","year":"2009","journal-title":"Blood"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/onc.2010.494","article-title":"Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors","volume":"30","author":"Pittoni","year":"2011","journal-title":"Oncogene"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1161\/01.res.0000024389.03152.22","article-title":"Actin capping protein: an essential element in protein kinase signaling to the myofilaments","volume":"90","author":"Pyle","year":"2002","journal-title":"Circulation Research"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"7113","DOI":"10.1074\/jbc.RA119.011895","article-title":"Sterile \u03b1-motif domain requirement for cellular signaling and survival","volume":"295","author":"Ray","year":"2020","journal-title":"The Journal of Biological Chemistry"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1146\/annurev.cb.11.110195.002433","article-title":"Control of actin assembly at filament ends","volume":"11","author":"Schafer","year":"1995","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1146\/annurev.cellbio.20.012103.094623","article-title":"Dynactin","volume":"20","author":"Schroer","year":"2004","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1091\/mbc.7.1.1","article-title":"Mutational analysis of capping protein function in Saccharomyces cerevisiae","volume":"7","author":"Sizonenko","year":"1996","journal-title":"Molecular Biology of the Cell"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/MOH.0b013e3280de2bf1","article-title":"Molecular insights into stress erythropoiesis","volume":"14","author":"Socolovsky","year":"2007","journal-title":"Current Opinion in Hematology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1085\/jgp.201812199","article-title":"CapZ integrates several signaling pathways in response to mechanical stiffness","volume":"151","author":"Sol\u00eds","year":"2019","journal-title":"The Journal of General Physiology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1182\/blood-2013-03-492710","article-title":"Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver","volume":"123","author":"Sui","year":"2014","journal-title":"Blood"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1111\/j.1349-7006.2008.00965.x","article-title":"Frequent aberrant methylation of the promoter region of sterile alpha motif domain 14 in pulmonary adenocarcinoma","volume":"99","author":"Sun","year":"2008","journal-title":"Cancer Science"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061237","article-title":"Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment","volume":"13","author":"Teng","year":"2021","journal-title":"Cancers"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1073\/pnas.1722281115","article-title":"Capping protein regulates actin dynamics during cytokinetic midbody maturation","volume":"115","author":"Terry","year":"2018","journal-title":"PNAS"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"6250","DOI":"10.1093\/emboj\/17.21.6250","article-title":"Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation","volume":"17","author":"Timokhina","year":"1998","journal-title":"The EMBO Journal"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"4107","DOI":"10.1091\/mbc.10.12.4107","article-title":"Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170","volume":"10","author":"Valetti","year":"1999","journal-title":"Molecular Biology of the Cell"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.molcel.2020.03.021","article-title":"ZAK\u03b1 Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains","volume":"78","author":"Vind","year":"2020","journal-title":"Molecular Cell"},{"key":"bib54","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35677","article-title":"Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions","volume":"7","author":"Wang","year":"2018","journal-title":"eLife"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1128\/MCB.17.3.1642","article-title":"Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line","volume":"17","author":"Weiss","year":"1997","journal-title":"Molecular and Cellular Biology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1182\/blood-2014-07-591453","article-title":"In vitro culture of stress erythroid progenitors identifies distinct progenitor populations and analogous human progenitors","volume":"125","author":"Xiang","year":"2015","journal-title":"Blood"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s10147-020-01647-4","article-title":"SAMD14 promoter methylation is strongly associated with gene expression and poor prognosis in gastric cancer","volume":"25","author":"Xu","year":"2020","journal-title":"International Journal of Clinical Oncology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.devcel.2005.06.008","article-title":"Mammalian CARMIL inhibits actin filament capping by capping protein","volume":"9","author":"Yang","year":"2005","journal-title":"Developmental Cell"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"3938","DOI":"10.1182\/blood-2003-05-1479","article-title":"Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system","volume":"102","author":"Zhang","year":"2003","journal-title":"Blood"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/76497\/elife-76497-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/76497\/elife-76497-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/76497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:15:14Z","timestamp":1697058914000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/76497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,17]]},"references-count":59,"alternative-id":["10.7554\/eLife.76497"],"URL":"https:\/\/doi.org\/10.7554\/elife.76497","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.31.474625","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2021.12.31.474625","asserted-by":"object"}],"references":[{"id-type":"accession","id":"GSE60103","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"doi","id":"10.6019\/PXD030467","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.76497.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.76497.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.76497.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,17]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e76497"}}