{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:47:15Z","timestamp":1790801235623,"version":"4.1.0"},"reference-count":64,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["771714"],"award-info":[{"award-number":["771714"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["LT000047\/2019-L"],"award-info":[{"award-number":["LT000047\/2019-L"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 1048-2016"],"award-info":[{"award-number":["ALTF 1048-2016"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["Marie Sk\u0142odowska-Curie Actions (839960)"],"award-info":[{"award-number":["Marie Sk\u0142odowska-Curie Actions (839960)"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e4o para a Ci\u00e9ncia e a Tecnologia","award":["CEECIND\/03322\/2018"],"award-info":[{"award-number":["CEECIND\/03322\/2018"]}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["17CVD03"],"award-info":[{"award-number":["17CVD03"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e4o para a Ci\u00e9ncia e a Tecnologia","award":["IF\/00412\/2012"],"award-info":[{"award-number":["IF\/00412\/2012"]}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["679368"],"award-info":[{"award-number":["679368"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e4o para a Ci\u00e9ncia e a Tecnologia","award":["CEECIND\/04251\/2017"],"award-info":[{"award-number":["CEECIND\/04251\/2017"]}]},{"name":"Funda\u00e7\u00e4o para a Ci\u00e9ncia e a Tecnologia","award":["CEECIND\/00697\/2018"],"award-info":[{"award-number":["CEECIND\/00697\/2018"]}]},{"name":"Funda\u00e7\u00e4o para a Ci\u00e9ncia e a Tecnologia","award":["PTDC\/MED-PAT\/31639\/2017"],"award-info":[{"award-number":["PTDC\/MED-PAT\/31639\/2017"]}]},{"name":"Funda\u00e7\u00e4o para a Ci\u00e9ncia e a Tecnologia","award":["PRECISE-LISBOA-01-0145-FEDER-016394"],"award-info":[{"award-number":["PRECISE-LISBOA-01-0145-FEDER-016394"]}]},{"name":"Funda\u00e7\u00e4o para a Ci\u00e9ncia e a Tecnologia","award":["EXPL\/BEX-BCM\/2258\/2013"],"award-info":[{"award-number":["EXPL\/BEX-BCM\/2258\/2013"]}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,7,4]]},"abstract":"<jats:p>\n                    <jats:italic>Trypanosoma congolense<\/jats:italic>\n                    causes a syndrome of variable severity in animals in Africa. Cerebral trypanosomiasis is a severe form, but the mechanism underlying this severity remains unknown. We developed a mouse model of acute cerebral trypanosomiasis and characterized the cellular, behavioral, and physiological consequences of this infection. We show large parasite sequestration in the brain vasculature for long periods of time (up to 8 hr) and extensive neuropathology that associate with ICAM1-mediated recruitment and accumulation of T cells in the brain parenchyma. Antibody-mediated ICAM1 blocking and lymphocyte absence reduce parasite sequestration in the brain and prevent the onset of cerebral trypanosomiasis. Here, we establish a mouse model of acute cerebral trypanosomiasis and we propose a mechanism whereby parasite sequestration, host ICAM1, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells play a pivotal role.\n                  <\/jats:p>","DOI":"10.7554\/elife.77440","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T07:15:30Z","timestamp":1657005330000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.77440","source":"Crossref","is-referenced-by-count":11,"title":["Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-6626","authenticated-orcid":true,"given":"Sara","family":"Silva Pereira","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01c27hj86","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina Molecular - Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-6789","authenticated-orcid":true,"given":"Mariana","family":"De Niz","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01c27hj86","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina Molecular - Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9152-4739","authenticated-orcid":true,"given":"Karine","family":"Serre","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01c27hj86","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina Molecular - Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-4363","authenticated-orcid":true,"given":"Marie","family":"Ouarn\u00e9","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01c27hj86","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina Molecular - Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-6197","authenticated-orcid":true,"given":"Joana E","family":"Coelho","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01c27hj86","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina Molecular - Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-3883","authenticated-orcid":true,"given":"Cl\u00e1udio A","family":"Franco","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01c27hj86","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina Molecular - Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-6586","authenticated-orcid":true,"given":"Luisa M","family":"Figueiredo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01c27hj86","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Medicina Molecular - Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa","place":["Lisbon, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003710","article-title":"Identification of trans-sialidases as a common mediator of endothelial cell activation by African trypanosomes","volume":"9","author":"Ammar","year":"2013","journal-title":"PLOS Pathogens"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nprot.2014.005","article-title":"Intravascular staining for discrimination of vascular and tissue leukocytes","volume":"9","author":"Anderson","year":"2014","journal-title":"Nature Protocols"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1550-7408.1978.tb04405.x","article-title":"Binding of Trypanosoma congolense to the walls of small blood vessels","volume":"25","author":"Banks","year":"1978","journal-title":"The Journal of Protozoology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.2307\/3280584","article-title":"Injury induced by Trypanosoma congolense adhesion to cell membranes","volume":"66","author":"Banks","year":"1980","journal-title":"The Journal of Parasitology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s00436-011-2452-y","article-title":"Highly debilitating natural Trypanosoma vivax infections in Brazilian calves: epidemiology, pathology, and probable transplacental transmission","volume":"110","author":"Batista","year":"2012","journal-title":"Parasitology Research"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"6369","DOI":"10.4049\/jimmunol.169.11.6369","article-title":"On the pathogenic role of brain-sequestered \u03b1\u03b2 CD8+ T cells in experimental cerebral malaria","volume":"169","author":"Belnoue","year":"2002","journal-title":"Journal of Immunology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0304-4017(02)00164-4","article-title":"Comparative pathogenicity of three genetically distinct types of Trypanosoma congolense in cattle: clinical observations and haematological changes","volume":"108","author":"Bengaly","year":"2002","journal-title":"Veterinary Parasitology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/341057a0","article-title":"Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum","volume":"341","author":"Berendt","year":"1989","journal-title":"Nature"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126498","article-title":"A comparison of phenotypic traits related to trypanotolerance in five west african cattle breeds highlights the value of shorthorn taurine breeds","volume":"10","author":"Berthier","year":"2015","journal-title":"PLOS ONE"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1590\/S1984-29612012000200009","article-title":"First report of Trypanosoma vivax outbreak in dairy cattle in S\u00e3o Paulo state","volume":"21","author":"Cadioli","year":"2012","journal-title":"Brazil. Rev Bras Parasitol Vet, Jaboticabal"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pathogens9090709","article-title":"An African canine trypanosomosis case import: is there a possibility of creating a secondary focus of Trypanosoma congolense infection in France?","volume":"9","author":"Calvet","year":"2020","journal-title":"Pathogens"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1073\/pnas.0801544105","article-title":"Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria","volume":"105","author":"Campanella","year":"2008","journal-title":"PNAS"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/sj.jid.5700670","article-title":"Increased ICAM-1 expression causes endothelial cell leakiness, cytoskeletal reorganization and junctional alterations","volume":"127","author":"Clark","year":"2007","journal-title":"The Journal of Investigative Dermatology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/dvg.20367","article-title":"Efficient, inducible Cre-recombinase activation in vascular endothelium","volume":"46","author":"Claxton","year":"2008","journal-title":"Genesis"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13023","article-title":"Intravital imaging of host-parasite interactions in skin and adipose tissues","volume":"21","author":"De Niz","year":"2019","journal-title":"Cellular Microbiology"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13024","article-title":"Intravital microscopy: Imaging host-parasite interactions in the brain","volume":"21","author":"De Niz","year":"2019","journal-title":"Cellular Microbiology"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13201","article-title":"Intravital imaging of host-parasite interactions in organs of the thoracic and abdominopelvic cavities","volume":"22","author":"De Niz","year":"2020","journal-title":"Cellular Microbiology"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109741","article-title":"Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence","volume":"36","author":"De Niz","year":"2021","journal-title":"Cell Reports"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/s0165-5728(02)00114-5","article-title":"The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier","volume":"128","author":"Dietrich","year":"2002","journal-title":"Journal of Neuroimmunology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.actatropica.2003.10.004","article-title":"Reduced microcirculatory flow in severe falciparum malaria: pathophysiology and electron-microscopic pathology","volume":"89","author":"Dondorp","year":"2004","journal-title":"Acta Tropica"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"154","DOI":"10.20506\/rst.17.1.1088","article-title":"Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomosis","volume":"17","author":"d\u2019Ieteren","year":"1998","journal-title":"Revue Scientifique et Technique"},{"key":"bib23","volume-title":"Controlling tsetse and trypanosomosis to protect African livestock keepers, public health and farmers\u2019 livelihoods","author":"Food and Agriculture Organization","year":"2019","unstructured":"Food and Agriculture Organization. 2019. Springer. Controlling tsetse and trypanosomosis to protect African livestock keepers, public health and farmers\u2019 livelihoods."},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pathogens8030097","article-title":"Interplay between attenuation- and virulence-factors of Babesia bovis and their contribution to the establishment of persistent infections in cattle","volume":"8","author":"Gallego-Lopez","year":"2019","journal-title":"Pathogens"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.vetpar.2016.10.013","article-title":"Trypanosoma vivax in water buffalo of the Venezuelan Llanos: An unusual outbreak of wasting disease in an endemic area of typically asymptomatic infections","volume":"230","author":"Garcia","year":"2016","journal-title":"Veterinary Parasitology"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009929","article-title":"Occurrence, diversity and distribution of Trypanosoma infections in cattle around the Akagera National Park, Rwanda","volume":"15","author":"Gashururu S","year":"2021","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02016","article-title":"Cerebral malaria in mouse and man","volume":"9","author":"Ghazanfari","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-5-71","article-title":"The origins of the trypanosome genome strains Trypanosoma brucei brucei TREU 927, T. b. gambiense DAL 972, T. vivax Y486 and T. congolense IL3000","volume":"5","author":"Gibson","year":"2012","journal-title":"Parasites & Vectors"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1080\/13550280802282934","article-title":"Traversal of human and animal trypanosomes across the blood-brain barrier","volume":"14","author":"Grab","year":"2008","journal-title":"Journal of Neurovirology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/0021-9975(79)90037-9","article-title":"Disease syndromes in sheep and goats naturally infected with Trypanosoma congolense","volume":"89","author":"Griffin","year":"1979","journal-title":"Journal of Comparative Pathology"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-05054-0","article-title":"Molecular identification and prevalence of trypanosomes in cattle distributed within the Jebba axis of the River Niger, Kwara state, Nigeria","volume":"14","author":"Habeeb","year":"2021","journal-title":"Parasites & Vectors"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1748-5827.1995.tb02835.x","article-title":"Trypanosoma congolense infection in two dogs","volume":"36","author":"Harrus","year":"1995","journal-title":"The Journal of Small Animal Practice"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/7284042","article-title":"Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda","volume":"2021","author":"Katabazi","year":"2021","journal-title":"BioMed Research International"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/0014-4894(70)90120-7","article-title":"Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose","volume":"28","author":"Lanham","year":"1970","journal-title":"Experimental Parasitology"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005242","article-title":"Trypanosoma brucei invasion and T-Cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes","volume":"10","author":"Laperchia","year":"2016","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/s1734-1140(09)70004-0","article-title":"ICAM-1 signaling in endothelial cells","volume":"61","author":"Lawson","year":"2009","journal-title":"Pharmacological Reports"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"bib38","first-page":"57","article-title":"Histological examination of wild animals naturally infected with pathogenic African trypanosomes","volume":"30","author":"Losos","year":"1973","journal-title":"Acta Tropica"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(73)90193-4","article-title":"Distribution of Trypanosoma congolense in tissues of cattle","volume":"67","author":"Losos","year":"1973","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/eji.1830220132","article-title":"ICAM-1-independent lymphocyte transmigration across high endothelium: differential up-regulation by interferon gamma, tumor necrosis factor-alpha and interleukin 1 beta","volume":"22","author":"May","year":"1992","journal-title":"European Journal of Immunology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.ijpara.2006.02.004","article-title":"Human cerebral malaria and the blood-brain barrier","volume":"36","author":"Medana","year":"2006","journal-title":"International Journal for Parasitology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep40838","article-title":"Non-pathogenic tissue-resident CD8+ T cells uniquely accumulate in the brains of lupus-prone mice","volume":"7","author":"Morawski","year":"2017","journal-title":"Scientific Reports"},{"key":"bib44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005170","article-title":"Mechanisms controlling anaemia in Trypanosoma congolense infected mice","volume":"4","author":"Noyes","year":"2009","journal-title":"PLOS ONE"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/s0304-4017(02)00017-1","article-title":"Distribution of Trypanosoma congolense in infected multimammate rats (Mastomys coucha): light and electron microscopical studies","volume":"105","author":"Ojok","year":"2002","journal-title":"Veterinary Parasitology"},{"key":"bib46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009764","article-title":"Role of T cells during the cerebral infection with Trypanosoma brucei","volume":"15","author":"Olivera","year":"2021","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nature Biotechnology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s003359900551","article-title":"Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment","volume":"8","author":"Rogers","year":"1997","journal-title":"Mammalian Genome"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S1473-3099(07)70022-1","article-title":"Malaria in pregnancy: pathogenesis and immunity","volume":"7","author":"Rogerson","year":"2007","journal-title":"The Lancet. Infectious Diseases"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1182\/blood.v93.3.886","article-title":"Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1\/intercellular adhesion molecule-1 and interleukin-15","volume":"93","author":"Sancho","year":"1999","journal-title":"Blood"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"PNAS"},{"key":"bib52","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2021.105507","article-title":"Co-infection with Trypanosoma congolense and Trypanosoma brucei is a significant risk factor for cerebral trypanosomosis in the equid population of the Gambia","volume":"197","author":"Savage","year":"2021","journal-title":"Preventive Veterinary Medicine"},{"key":"bib53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124080","article-title":"Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria","volume":"10","author":"Schumak","year":"2015","journal-title":"PLOS ONE"},{"key":"bib54","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.190036","article-title":"Tissue tropism in parasitic diseases","volume":"9","author":"Silva Pereira","year":"2019","journal-title":"Open Biology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/icb.2017.56","article-title":"IFN-\u03b3 promotes transendothelial migration of CD4+ T cells across the blood-brain barrier","volume":"95","author":"Sonar","year":"2017","journal-title":"Immunology and Cell Biology"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-181","article-title":"Loss of neurovirulence is associated with reduction of cerebral capillary sequestration during acute Babesia bovis infection","volume":"6","author":"Sondgeroth","year":"2013","journal-title":"Parasites & Vectors"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s11255-009-9608-z","article-title":"NGAL: A biomarker of acute kidney injury and other systemic conditions","volume":"42","author":"Soni","year":"2010","journal-title":"International Urology and Nephrology"},{"key":"bib58","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98911","article-title":"CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria","volume":"3","author":"Sorensen","year":"2018","journal-title":"JCI Insight"},{"key":"bib59","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00100","article-title":"Pathogenesis of cerebral malaria--inflammation and cytoadherence","volume":"4","author":"Storm","year":"2014","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"PNAS"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.pt.2013.04.006","article-title":"Pathogenesis of malaria-associated acute respiratory distress syndrome","volume":"29","author":"Van den Steen","year":"2013","journal-title":"Trends in Parasitology"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1590\/S0100-736X2014001000002","article-title":"Babesia bovis: expression of adhesion molecules in bovine umbilical endothelial cells stimulated with plasma from infected cattle","volume":"34","author":"Vargas","year":"2014","journal-title":"Pesquisa Veterin\u00e1ria Brasileira"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Research"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1080\/00034983.1983.11811740","article-title":"Enzyme polymorphism and the distribution of Trypanosoma congolense isolates","volume":"77","author":"Young","year":"1983","journal-title":"Annals of Tropical Medicine and Parasitology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/77440\/elife-77440-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/77440\/elife-77440-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/77440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:17:39Z","timestamp":1697059059000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/77440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":64,"alternative-id":["10.7554\/eLife.77440"],"URL":"https:\/\/doi.org\/10.7554\/elife.77440","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1050698\/v1","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"accession","id":"PRJNA777781","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.742221173.793598500","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.77440.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.77440.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.77440.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,5]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e77440"}}