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In this study, we used a mouse model of endometrial repair and three transgenic lines of mice to investigate whether epithelial cells that become incorporated into the newly formed luminal epithelium have their origins in one or more of the mesenchymal cell types present in the stromal compartment of the endometrium. Using scRNAseq, we identified a novel population of PDGFRb + mesenchymal stromal cells that developed a unique transcriptomic signature in response to endometrial breakdown\/repair. These cells expressed genes usually considered specific to epithelial cells and in silico trajectory analysis suggested they were stromal fibroblasts in transition to becoming epithelial cells. To confirm our hypothesis we used a lineage tracing strategy to compare the fate of stromal fibroblasts (PDGFRa+) and stromal perivascular cells (NG2\/CSPG4+). We demonstrated that stromal fibroblasts can undergo a mesenchyme to epithelial transformation and become incorporated into the re-epithelialised luminal surface of the repaired tissue. This study is the first to discover a novel population of wound-responsive, plastic endometrial stromal fibroblasts that contribute to the rapid restoration of an intact luminal epithelium during endometrial repair. These findings form a platform for comparisons both to endometrial pathologies which involve a fibrotic response (Asherman\u2019s syndrome, endometriosis) as well as other mucosal tissues which have a variable response to wounding.<\/jats:p>","DOI":"10.7554\/elife.77663","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T06:15:20Z","timestamp":1671171320000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.77663","source":"Crossref","is-referenced-by-count":65,"title":["Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation"],"prefix":"10.7554","volume":"11","author":[{"given":"Phoebe M","family":"Kirkwood","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01nrxwf90","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Inflammation Research, University of Edinburgh","place":["Edinburgh, United 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