{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:15:29Z","timestamp":1785402929487,"version":"3.56.0"},"reference-count":60,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2098"],"award-info":[{"award-number":["GRK2098"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2581"],"award-info":[{"award-number":["GRK2581"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,9,9]]},"abstract":"<jats:p>\n                    Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However, the impact of cell-intrinsic Ac activity and ceramide on the course of\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection remains elusive. Here, we use Ac-deficient mice with ubiquitously increased ceramide levels to elucidate the role of endogenous Ac activity in a murine malaria model. Interestingly, ablation of Ac leads to alleviated parasitemia associated with decreased T cell responses in the early phase of\n                    <jats:italic>Plasmodium yoelii<\/jats:italic>\n                    infection. Mechanistically, we identified dysregulated erythropoiesis with reduced numbers of reticulocytes, the preferred host cells of\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    , in Ac-deficient mice. Furthermore, we demonstrate that administration of the Ac inhibitor carmofur to wildtype mice has similar effects on\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    infection and erythropoiesis. Notably, therapeutic carmofur treatment after manifestation of\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    infection is efficient in reducing parasitemia. Hence, our results provide evidence for the involvement of Ac and ceramide in controlling\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    infection by regulating red blood cell development.\n                  <\/jats:p>","DOI":"10.7554\/elife.77975","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T08:00:23Z","timestamp":1662969623000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.77975","source":"Crossref","is-referenced-by-count":7,"title":["The acid ceramidase\/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis"],"prefix":"10.7554","volume":"11","author":[{"given":"Anne","family":"G\u00fcnther","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0746-5591","authenticated-orcid":true,"given":"Matthias","family":"Hose","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Abberger","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-3275","authenticated-orcid":true,"given":"Fabian","family":"Schumacher","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046ak2485","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Pharmacy, Freie Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Veith","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01hcx6992","id-type":"ROR","asserted-by":"publisher"}],"name":"Molecular Parasitology, Institute of Biology\/Faculty for Life Sciences, Humboldt University Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Kleuser","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046ak2485","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Pharmacy, Freie Universit\u00e4t Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-8591","authenticated-orcid":true,"given":"Kai","family":"Matuschewski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01hcx6992","id-type":"ROR","asserted-by":"publisher"}],"name":"Molecular Parasitology, Institute of Biology\/Faculty for Life Sciences, Humboldt University Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Sebastian","family":"Lang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Immunology, University Hospital Essen, University Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Gulbins","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Molecular Biology, University of Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-1698","authenticated-orcid":true,"given":"Jan","family":"Buer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-2892","authenticated-orcid":true,"given":"Astrid M","family":"Westendorf","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6020-0886","authenticated-orcid":true,"given":"Wiebke","family":"Hansen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mz5ra38","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen","place":["Essen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1159\/000109767","article-title":"Antimalarial drug toxicity: a review","volume":"53","author":"AlKadi","year":"2007","journal-title":"Chemotherapy"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"D539","DOI":"10.1093\/nar\/gkn814","article-title":"PlasmoDB: a functional genomic database for malaria parasites","volume":"37","author":"Aurrecoechea","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00677-20","article-title":"Acid ceramidase rescues cystic fibrosis mice from pulmonary infections","volume":"89","author":"Becker","year":"2021","journal-title":"Infection and Immunity"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.3324\/haematol.2012.065854","article-title":"Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria","volume":"97","author":"Casals-Pascual","year":"2012","journal-title":"Haematologica"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1182\/blood-2003-08-2887","article-title":"Inappropriately low reticulocytosis in severe malarial anemia correlates with suppression in the development of late erythroid precursors","volume":"103","author":"Chang","year":"2004","journal-title":"Blood"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1086\/381458","article-title":"Modulation of the course and outcome of blood-stage malaria by erythropoietin-induced reticulocytosis","volume":"189","author":"Chang","year":"2004","journal-title":"The Journal of Infectious Diseases"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"17413","DOI":"10.1073\/pnas.0909296106","article-title":"Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis","volume":"106","author":"Chen","year":"2009","journal-title":"PNAS"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1365-2257.1991.tb00267.x","article-title":"Flow cytometric reticulocyte analysis using thiazole orange; clinical experience and technical limitations","volume":"13","author":"Chin-Yee","year":"1991","journal-title":"Clinical and Laboratory Haematology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/00034983.1948.11685353","article-title":"Infection of reticulocytes by Plasmodium falciparum and plasmodium malariae in hyperendemic indigenous malaria","volume":"42","author":"Chwatt","year":"1948","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.2174\/092986709788682182","article-title":"Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate","volume":"16","author":"Claus","year":"2009","journal-title":"Current Medicinal Chemistry"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S0022-2275(20)36756-0","article-title":"Stimulation of erythroblast maturation in vitro by sphingolipids","volume":"15","author":"Clayton","year":"1974","journal-title":"Journal of Lipid Research"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jtbi.2008.12.019","article-title":"Low red cell production may protect against severe anemia during a malaria infection--insights from modeling","volume":"257","author":"Cromer","year":"2009","journal-title":"Journal of Theoretical Biology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/s0301-472x(99)00054-5","article-title":"Inhibition of human erythroid colony formation by ceramide","volume":"27","author":"Dallalio","year":"1999","journal-title":"Experimental Hematology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.3324\/haematol.2009.019331","article-title":"Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria","volume":"95","author":"de Mast","year":"2010","journal-title":"Haematologica"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1021\/acs.jmedchem.8b01723","article-title":"Molecular mechanism of inhibition of acid ceramidase by carmofur","volume":"62","author":"Dementiev","year":"2019","journal-title":"Journal of Medicinal Chemistry"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1096\/fj.06-7016com","article-title":"Acid ceramidase is a novel factor required for early embryo survival","volume":"21","author":"Eliyahu","year":"2007","journal-title":"FASEB Journal"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"35352","DOI":"10.1074\/jbc.M103066200","article-title":"Human acid ceramidase: processing, glycosylation, and lysosomal targeting","volume":"276","author":"Ferlinz","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"bib18","first-page":"561","volume-title":"The American Journal of Tropical Medicine and Hygiene","author":"Garnham","year":"1966"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00218","article-title":"Use of acid ceramidase and sphingosine kinase inhibitors as antiviral compounds against measles virus infection of lymphocytes in vitro","volume":"7","author":"Grafen","year":"2019","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.chom.2015.08.003","article-title":"Profiling the essential nature of lipid metabolism in asexual blood and gametocyte stages of Plasmodium falciparum","volume":"18","author":"Gulati","year":"2015","journal-title":"Cell Host & Microbe"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1038\/s41380-018-0090-9","article-title":"Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide","volume":"23","author":"Gulbins","year":"2018","journal-title":"Molecular Psychiatry"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0166-6851(91)90137-u","article-title":"The accumulation and metabolism of a fluorescent ceramide derivative in Plasmodium falciparum-infected erythrocytes","volume":"49","author":"Haldar","year":"1991","journal-title":"Molecular and Biochemical Parasitology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01225","article-title":"T cell-specific overexpression of acid sphingomyelinase results in elevated T cell activation and reduced parasitemia during plasmodium yoelii infection","volume":"10","author":"Hose","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"623","DOI":"10.4269\/ajtmh.2007.77.623","article-title":"Relationship of hepcidin with parasitemia and anemia among patients with uncomplicated Plasmodium falciparum malaria in ghana","volume":"77","author":"Howard","year":"2007","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1182\/blood-2018-03-838516","article-title":"Enhanced phosphocholine metabolism is essential for terminal erythropoiesis","volume":"131","author":"Huang","year":"2018","journal-title":"Blood"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1182\/blood-2014-05-516252","article-title":"Molecular liaisons between erythropoiesis and iron metabolism","volume":"124","author":"Kautz","year":"2014","journal-title":"Blood"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"347","DOI":"10.4269\/ajtmh.1938.s1-18.347","article-title":"The infection of reticulocytes by plasmodium vivax 1","volume":"s1-18","author":"Kitchen","year":"1938","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-3-49","article-title":"Anti-plasmodium activity of ceramide analogs","volume":"3","author":"Labaied","year":"2004","journal-title":"Malaria Journal"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15072-8","article-title":"Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease","volume":"11","author":"Lang","year":"2020","journal-title":"Nature Communications"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.680136","article-title":"Rodent malaria erythrocyte preference assessment by an ex vivo tropism assay","volume":"11","author":"Leong","year":"2021","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1006\/geno.2002.6686","article-title":"Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes","volume":"79","author":"Li","year":"2002","journal-title":"Genomics"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.bbalip.2007.05.007","article-title":"Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization","volume":"1771","author":"Li","year":"2007","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.bbalip.2008.06.002","article-title":"Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate","volume":"1781","author":"Mao","year":"2008","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1462-5822.2010.01523.x","article-title":"Strain-specific spleen remodelling in plasmodium yoelii infections in balb\/c mice facilitates adherence and spleen macrophage-clearance escape","volume":"13","author":"Martin-Jaular","year":"2011","journal-title":"Cellular Microbiology"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-434","article-title":"Reticulocyte-prone malaria parasites predominantly invade cd71hi immature cells: implications for the development of an in vitro culture for plasmodium vivax","volume":"12","author":"Mart\u00edn-Jaular","year":"2013","journal-title":"Malaria Journal"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1021\/ml2002136","article-title":"Sphingolipid analogues inhibit development of malaria parasites","volume":"3","author":"Meyer","year":"2012","journal-title":"ACS Medicinal Chemistry Letters"},{"key":"bib39","first-page":"137","article-title":"Leukoencephalopathy caused by antineoplastic drugs","volume":"60","author":"Mizutani","year":"2008","journal-title":"Brain and Nerve = Shinkei Kenkyu No Shinpo"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1042\/bj2050419","article-title":"Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with farber disease and controls","volume":"205","author":"Momoi","year":"1982","journal-title":"The Biochemical Journal"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01076","article-title":"From erythroblasts to mature red blood cells: organelle clearance in mammals","volume":"8","author":"Moras","year":"2017","journal-title":"Frontiers in Physiology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1194\/jlr.RA120000682","article-title":"Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro","volume":"61","author":"Naser","year":"2020","journal-title":"Journal of Lipid Research"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/MOH.0000000000000234","article-title":"Metabolic regulation of hematopoietic stem cell commitment and erythroid differentiation","volume":"23","author":"Oburoglu","year":"2016","journal-title":"Current Opinion in Hematology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"19076","DOI":"10.1016\/S0021-9258(19)47268-2","article-title":"Sphingomyelin turnover induced by vitamin D3 in HL-60 cells","volume":"264","author":"Okazaki","year":"1989","journal-title":"Journal of Biological Chemistry"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1038\/s41418-018-0245-x","article-title":"Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem\/progenitor cells","volume":"26","author":"Orsini","year":"2019","journal-title":"Cell Death and Differentiation"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s000180300049","article-title":"Ceramide mediates growth inhibition of the Plasmodium falciparum parasite","volume":"60","author":"Pankova-Kholmyansky","year":"2003","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib47","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9310905","article-title":"Erythropoiesis in malaria infections and factors modifying the erythropoietic response","volume":"2016","author":"Pathak","year":"2016","journal-title":"Anemia"},{"key":"bib48","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00671","article-title":"CD4 T-cell subsets in malaria: TH1\/TH2 revisited","volume":"5","author":"Perez-Mazliah","year":"2014","journal-title":"Frontiers in Immunology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/nm.2368","article-title":"Host-mediated regulation of superinfection in malaria","volume":"17","author":"Portugal","year":"2011","journal-title":"Nature Medicine"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1038\/srep01035","article-title":"Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity","volume":"3","author":"Realini","year":"2013","journal-title":"Scientific Reports"},{"key":"bib51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80658-7","article-title":"Erythrocyte sphingosine kinase regulates intraerythrocytic development of Plasmodium falciparum","volume":"11","author":"Sah","year":"2021","journal-title":"Scientific Reports"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/BF01949417","article-title":"Effects of sphingolipids on erythroblastic maturation in the mouse","volume":"38","author":"Scaro","year":"1982","journal-title":"Experientia"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/cbf.3196","article-title":"Ceranib-2-induced suicidal erythrocyte death","volume":"34","author":"Signoretto","year":"2016","journal-title":"Cell Biochemistry and Function"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1128\/AAC.48.5.1803-1806.2004","article-title":"Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening","volume":"48","author":"Smilkstein","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00125","article-title":"Iron, anemia and hepcidin in malaria","volume":"5","author":"Spottiswoode","year":"2014","journal-title":"Frontiers in Pharmacology"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054974","article-title":"Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated","volume":"8","author":"Spry","year":"2013","journal-title":"PLOS ONE"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1128\/AAC.43.3.598","article-title":"8-aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization","volume":"43","author":"Vennerstrom","year":"1999","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"6410","DOI":"10.4049\/jimmunol.1101436","article-title":"Hepcidin is regulated during blood-stage malaria and plays a protective role in malaria infection","volume":"187","author":"Wang","year":"2011","journal-title":"Journal of Immunology"},{"key":"bib59","doi-asserted-by":"crossref","DOI":"10.30875\/6c551ba0-en","volume-title":"World Malaria Report 2021","author":"World health organization","year":"2021","unstructured":"World health organization. 2021. WHO. World Malaria Report 2021."},{"key":"bib60","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0845-z","article-title":"Acid ceramidase deficiency: farber disease and SMA-PME","volume":"13","author":"Yu","year":"2018","journal-title":"Orphanet Journal of Rare Diseases"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/77975\/elife-77975-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/77975\/elife-77975-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/77975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:19:18Z","timestamp":1697059158000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/77975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":60,"alternative-id":["10.7554\/eLife.77975"],"URL":"https:\/\/doi.org\/10.7554\/elife.77975","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.03.08.483432","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.03.08.483432","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.77975.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.77975.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.77975.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,12]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e77975"}}