{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:39:22Z","timestamp":1792517962499,"version":"4.5.0"},"reference-count":64,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["FRSM 3.4516.11"],"award-info":[{"award-number":["FRSM 3.4516.11"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002910","name":"F\u00e9d\u00e9ration Wallonie-Bruxelles","doi-asserted-by":"publisher","award":["ARC-SLEEPDEM 17\/09"],"award-info":[{"award-number":["ARC-SLEEPDEM 17\/09"]}],"id":[{"id":"10.13039\/501100002910","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["RAdiomed"],"award-info":[{"award-number":["RAdiomed"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["grant number 190750"],"award-info":[{"award-number":["grant number 190750"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004313","name":"General Electric","doi-asserted-by":"publisher","award":["ISS290"],"award-info":[{"award-number":["ISS290"]}],"id":[{"id":"10.13039\/100004313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021790","name":"Fondation Recherche Alzheimer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100021790","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,5,23]]},"abstract":"<jats:p>\n                    Sleep alteration is a hallmark of ageing and emerges as a risk factor for Alzheimer\u2019s disease (AD). While the fine-tuned coalescence of sleep microstructure elements may influence age-related cognitive trajectories, its association with AD processes is not fully established. Here, we investigated whether the coupling of spindles and slow waves (SW) is associated with early amyloid-\u03b2 (A\u03b2) brain burden, a hallmark of AD neuropathology, and cognitive change over 2 years in 100 healthy individuals in late-midlife (50\u201370 years; 68 women). We found that, in contrast to other sleep metrics, earlier occurrence of spindles on slow-depolarisation SW is associated with higher medial prefrontal cortex A\u03b2 burden (p=0.014, r\u00b2\n                    <jats:sub>\u03b2*<\/jats:sub>\n                    =0.06) and is predictive of greater longitudinal memory decline in a large subsample (p=0.032, r\u00b2\n                    <jats:sub>\u03b2*<\/jats:sub>\n                    =0.07, N=66). These findings unravel early links between sleep, AD-related processes, and cognition and suggest that altered coupling of sleep microstructure elements, key to its mnesic function, contributes to poorer brain and cognitive trajectories in ageing.\n                  <\/jats:p>","DOI":"10.7554\/elife.78191","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T11:15:21Z","timestamp":1653390921000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.78191","source":"Crossref","is-referenced-by-count":63,"title":["Timely coupling of sleep spindles and slow waves linked to early amyloid-\u03b2 burden and predicts memory decline"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-0859","authenticated-orcid":true,"given":"Daphne","family":"Chylinski","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Van Egroo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justinas","family":"Narbutas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]},{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"Psychology and Cognitive Neuroscience Research Unit, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Muto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ali","family":"Bahri","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Berthomier","sequence":"additional","affiliation":[{"name":"Physip SA","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-9241","authenticated-orcid":true,"given":"Eric","family":"Salmon","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]},{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"Psychology and Cognitive Neuroscience Research Unit, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]},{"name":"Department of Neurology, University Hospital of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4556-9490","authenticated-orcid":true,"given":"Christine","family":"Bastin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]},{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"Psychology and Cognitive Neuroscience Research Unit, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4990-425X","authenticated-orcid":true,"given":"Christophe","family":"Phillips","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]},{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-In Silico Medicine, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Collette","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]},{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"Psychology and Cognitive Neuroscience Research Unit, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Maquet","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]},{"name":"Department of Neurology, University Hospital of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-2370","authenticated-orcid":true,"given":"Julie","family":"Carrier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Advanced Research in Sleep Medicine, Universit\u00e9 de Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Lina","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Advanced Research in Sleep Medicine, Universit\u00e9 de Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2483-2752","authenticated-orcid":true,"given":"Gilles","family":"Vandewalle","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00afp2z80","id-type":"ROR","asserted-by":"publisher"}],"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0361-9230(93)90016-5","article-title":"A model of human sleep homeostasis based on EEG slow-wave activity: quantitative comparison of data and simulations","volume":"31","author":"Achermann","year":"1993","journal-title":"Brain Research Bulletin"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/s0306-4522(97)00186-3","article-title":"Low-frequency (< 1 Hz) oscillations in the human sleep electroencephalogram","volume":"81","author":"Achermann","year":"1997","journal-title":"Neuroscience"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/s41583-019-0223-4","article-title":"Oscillating circuitries in the sleeping brain","volume":"20","author":"Adamantidis","year":"2019","journal-title":"Nature Reviews. Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"NeuroImage"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"NeuroImage"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.smrv.2018.08.001","article-title":"Biomarkers of dementia in obstructive sleep apnea","volume":"42","author":"Baril","year":"2018","journal-title":"Sleep Medicine Reviews"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1093\/sleep\/30.11.1587","article-title":"Automatic analysis of single-channel sleep EEG: validation in healthy individuals","volume":"30","author":"Berthomier","year":"2007","journal-title":"Sleep"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64337","article-title":"Sleeping at the switch","volume":"10","author":"Bouchard","year":"2021","journal-title":"eLife"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1111\/j.1460-9568.2010.07543.x","article-title":"Sleep slow wave changes during the middle years of life","volume":"33","author":"Carrier","year":"2011","journal-title":"The European Journal of Neuroscience"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3390\/clockssleep2030020","article-title":"Validation of an Automatic Arousal Detection Algorithm for Whole-Night Sleep EEG Recordings","volume":"2","author":"Chylinski","year":"2020","journal-title":"Clocks & Sleep"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.152858","article-title":"Heterogeneity in the links between sleep arousals, amyloid-\u03b2, and cognition","volume":"6","author":"Chylinski","year":"2021","journal-title":"JCI Insight"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neuroimage.2005.05.028","article-title":"Cerebral correlates of delta waves during non-REM sleep revisited","volume":"28","author":"Dang-Vu","year":"2005","journal-title":"NeuroImage"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1093\/sleep\/33.12.1589","article-title":"Functional neuroimaging insights into the physiology of human sleep","volume":"33","author":"Dang-Vu","year":"2010","journal-title":"Sleep"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3233\/JAD-180640","article-title":"Risk of Alzheimer\u2019s Disease in Obstructive Sleep Apnea Syndrome: Amyloid-\u03b2 and Tau Imaging","volume":"66","author":"Elias","year":"2018","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behavior Research Methods"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1152\/physrev.00042.2018","article-title":"Sleep Spindles: Mechanisms and Functions","volume":"100","author":"Fernandez","year":"2020","journal-title":"Physiological Reviews"},{"key":"bib17","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1523\/JNEUROSCI.22-15-06830.2002","article-title":"Learning-dependent increases in sleep spindle density","volume":"22","author":"Gais","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsy113","article-title":"The association between white matter and sleep spindles differs in young and older individuals","volume":"41","author":"Gaudreault","year":"2018","journal-title":"Sleep"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1212\/WNL.0000000000004643","article-title":"In vivo staging of regional amyloid deposition","volume":"89","author":"Grothe","year":"2017","journal-title":"Neurology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.neuron.2017.11.020","article-title":"Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting","volume":"97","author":"Helfrich","year":"2018","journal-title":"Neuron"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-16915-0","article-title":"Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep","volume":"11","author":"Hubbard","year":"2020","journal-title":"Nature Communications"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1080\/02664763.2016.1193725","article-title":"An R2statistic for fixed effects in the generalized linear mixed model","volume":"44","author":"Jaeger","year":"2017","journal-title":"Journal of Applied Statistics"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1001\/jamaneurol.2013.2334","article-title":"Sleep quality and preclinical Alzheimer disease","volume":"70","author":"Ju","year":"2013","journal-title":"JAMA Neurology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrneurol.2013.269","article-title":"Sleep and Alzheimer disease pathology--a bidirectional relationship","volume":"10","author":"Ju","year":"2014","journal-title":"Nature Reviews. Neurology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1093\/brain\/awx148","article-title":"Slow wave sleep disruption increases cerebrospinal fluid amyloid-\u03b2 levels","volume":"140","author":"Ju","year":"2017","journal-title":"Brain"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1226","article-title":"A practical guide and power analysis for GLMMs: detecting among treatment variation in random effects","volume":"3","author":"Kain","year":"2015","journal-title":"PeerJ"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science (New York, N.Y.)"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jalz.2014.07.003","article-title":"The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET","volume":"11","author":"Klunk","year":"2015","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/jsr.12108","article-title":"Sleep spindles and rapid eye movement sleep as predictors of next morning cognitive performance in healthy middle-aged and older participants","volume":"23","author":"Lafortune","year":"2014","journal-title":"Journal of Sleep Research"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"18195","DOI":"10.1073\/pnas.0408089101","article-title":"Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking alpha1G-subunit of T-type calcium channels","volume":"101","author":"Lee","year":"2004","journal-title":"PNAS"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.5665\/sleep.2802","article-title":"Sleep Fragmentation and the Risk of Incident Alzheimer\u2019s Disease and Cognitive Decline in Older Persons","volume":"36","author":"Lim","year":"2013","journal-title":"Sleep"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/ana.25117","article-title":"Effect of sleep on overnight cerebrospinal fluid amyloid \u03b2 kinetics","volume":"83","author":"Lucey","year":"2018","journal-title":"Annals of Neurology"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau6550","article-title":"Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer\u2019s disease","volume":"11","author":"Lucey","year":"2019","journal-title":"Science Translational Medicine"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/nn.4035","article-title":"\u03b2-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation","volume":"18","author":"Mander","year":"2015","journal-title":"Nature Neuroscience"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1523\/JNEUROSCI.3769-16.2017","article-title":"Tau and \u03b2-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging","volume":"37","author":"Marks","year":"2017","journal-title":"The Journal of Neuroscience"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.neurobiolaging.2012.05.020","article-title":"Topography of age-related changes in sleep spindles","volume":"34","author":"Martin","year":"2013","journal-title":"Neurobiology of Aging"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"4494","DOI":"10.1523\/JNEUROSCI.3127-12.2013","article-title":"The critical role of sleep spindles in hippocampal-dependent memory: a pharmacology study","volume":"33","author":"Mednick","year":"2013","journal-title":"The Journal of Neuroscience"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncir.2017.00092","article-title":"The Roles of Cortical Slow Waves in Synaptic Plasticity and Memory Consolidation","volume":"11","author":"Miyamoto","year":"2017","journal-title":"Frontiers in Neural Circuits"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.5665\/SLEEP.1290","article-title":"Fast and slow spindles during the sleep slow oscillation: disparate coalescence and engagement in memory processing","volume":"34","author":"M\u00f6lle","year":"2011","journal-title":"Sleep"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1126\/science.aah4968","article-title":"Mechanisms linking circadian clocks, sleep, and neurodegeneration","volume":"354","author":"Musiek","year":"2016","journal-title":"Science (New York, N.Y.)"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3233\/JAD-210332","article-title":"Associations Between Cognitive Complaints, Memory Performance, Mood, and Amyloid-\u03b2 Accumulation in Healthy Amyloid Negative Late-Midlife Individuals","volume":"83","author":"Narbutas","year":"2021","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1001\/jamaneurol.2014.1173","article-title":"Effect of 1 night of total sleep deprivation on cerebrospinal fluid \u03b2-amyloid 42 in healthy middle-aged men: A randomized clinical trial","volume":"71","author":"Ooms","year":"2014","journal-title":"JAMA Neurology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"393","DOI":"10.5664\/jcsm.8864","article-title":"Automatic analysis of single-channel sleep EEG in a large spectrum of sleep disorders","volume":"17","author":"Peter-Derex","year":"2021","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"bib44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2020.105680","article-title":"Relationship between brain AD biomarkers and episodic memory performance in healthy aging","volume":"148","author":"Rizzolo","year":"2021","journal-title":"Brain and Cognition"},{"key":"bib45","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa186","article-title":"Are age and sex effects on sleep slow waves only a matter of electroencephalogram amplitude?","volume":"44","author":"Rosinvil","year":"2021","journal-title":"Sleep"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.neuroimage.2013.06.021","article-title":"Structural brain correlates of human sleep oscillations","volume":"83","author":"Saletin","year":"2013","journal-title":"NeuroImage"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"8976","DOI":"10.1523\/JNEUROSCI.2464-06.2006","article-title":"Encoding difficulty promotes postlearning changes in sleep spindle activity during napping","volume":"26","author":"Schmidt","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1212\/WNL.0000000000004171","article-title":"Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults","volume":"89","author":"Sprecher","year":"2017","journal-title":"Neurology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1016\/j.neuropsychologia.2012.12.014","article-title":"A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment","volume":"51","author":"Stark","year":"2013","journal-title":"Neuropsychologia"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1037\/bne0000055","article-title":"Stability of age-related deficits in the mnemonic similarity task across task variations","volume":"129","author":"Stark","year":"2015","journal-title":"Behavioral Neuroscience"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"d878","DOI":"10.2741\/1043","article-title":"The corticothalamic system in sleep","volume":"8","author":"Steriade","year":"2003","journal-title":"Frontiers in Bioscience"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuroimage.2019.01.029","article-title":"hMRI - A toolbox for quantitative MRI in neuroscience and clinical research","volume":"194","author":"Tabelow","year":"2019","journal-title":"NeuroImage"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage"},{"key":"bib54","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1796715","article-title":"Sleep Spindles as Facilitators of Memory Formation and Learning","volume":"2016","author":"Ulrich","year":"2016","journal-title":"Neural Plasticity"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0693-y","article-title":"Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations","volume":"2","author":"Van Egroo","year":"2019","journal-title":"Communications Biology"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz017","article-title":"Sleep-wake regulation and the hallmarks of the pathogenesis of Alzheimer\u2019s disease","volume":"42","author":"Van Egroo","year":"2019","journal-title":"Sleep"},{"key":"bib57","article-title":"Slow wave-spindle coupling and amyloid","volume-title":"Software Heritage","author":"Vandewalle","year":"2022","unstructured":"Vandewalle G. 2022. Slow wave-spindle coupling and amyloid. Software Heritage. swh:1:rev:a63699b5f06c98ade284689af5671e13c77751f2. https:\/\/archive.softwareheritage.org\/swh:1:dir:b62ef7d1bbe930c8123a4bcfd4bc8c50a2648ea8;origin=https:\/\/gitlab.uliege.be\/CyclotronResearchCentre\/Public\/fasst\/slow-wave-spindle-coupling-and-amyloid;visit=swh:1:snp:d535c7a87c3c73c2ea4be037143c3007975d0b1b;anchor=swh:1:rev:a63699b5f06c98ade284689af5671e13c77751f2."},{"key":"bib58","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41386-019-0478-5","article-title":"Bidirectional relationship between sleep and Alzheimer\u2019s disease: role of amyloid, tau, and other factors","volume":"45","author":"Wang","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"bib59","article-title":"Multi-parameter mapping of the human brain at 1mm resolution in less than 20 minutes","volume":"16","author":"Weiskopf","year":"2008","journal-title":"Proceeding Int. Soc. Magetic Reson. Med"},{"key":"bib60","volume-title":"Sleep as a Potential Biomarker of Tau and \u03b2-Amyloid Burden in the Human Brain Abbreviated Title Authors Center for Human Sleep Science","author":"Winer","year":"2019"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1016\/j.cub.2020.08.017","article-title":"Sleep Disturbance Forecasts \u03b2-Amyloid Accumulation across Subsequent Years","volume":"30","author":"Winer","year":"2020","journal-title":"Current Biology"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/jnc.13887","article-title":"Pittsburgh Compound-B (PiB) binds amyloid \u03b2-protein protofibrils","volume":"140","author":"Yamin","year":"2017","journal-title":"Journal of Neurochemistry"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jneumeth.2015.11.005","article-title":"Automatic artifacts and arousals detection in whole-night sleep EEG recordings","volume":"258","author":"\u2019t Wallant","year":"2016","journal-title":"Journal of Neuroscience Methods"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/78191\/elife-78191-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/78191\/elife-78191-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/78191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:19:55Z","timestamp":1697059195000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/78191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":64,"alternative-id":["10.7554\/eLife.78191"],"URL":"https:\/\/doi.org\/10.7554\/elife.78191","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.03.15.484463","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.03.15.484463","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.78191.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.78191.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.78191.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,31]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e78191"}}