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However, little attention has been paid to the characteristics of the immune microenvironment in AM. Therefore, in this study, we collected clinical samples from Chinese patients with AM and conducted single-cell RNA sequencing to analyze the heterogeneity of its tumor microenvironments (TMEs) and the molecular regulatory network. Our analysis revealed that genes, such as\n                    <jats:italic>TWIST1<\/jats:italic>\n                    ,\n                    <jats:italic>EREG<\/jats:italic>\n                    ,\n                    <jats:italic>TNFRSF9<\/jats:italic>\n                    , and\n                    <jats:italic>CTGF<\/jats:italic>\n                    could drive the deregulation of various TME components. The molecular interaction relationships between TME cells, such as MIF-CD44 and TNFSF9-TNFRSF9, might be an attractive target for developing novel immunotherapeutic agents.\n                  <\/jats:p>","DOI":"10.7554\/elife.78616","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T06:00:16Z","timestamp":1658901616000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.78616","source":"Crossref","is-referenced-by-count":21,"title":["Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments"],"prefix":"10.7554","volume":"11","author":[{"given":"Zan","family":"He","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Medical General Hospital of People's Liberation Army","place":["Beijing, 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