{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:05:20Z","timestamp":1785423920494,"version":"3.56.0"},"reference-count":91,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GGP12282"],"award-info":[{"award-number":["GGP12282"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2010R8JK2X_006"],"award-info":[{"award-number":["2010R8JK2X_006"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["777204"],"award-info":[{"award-number":["777204"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,3,15]]},"abstract":"<jats:p>\n                    Palladin (PALLD) belongs to the PALLD\/myopalladin (MYPN)\/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line. PALLD is ubiquitously expressed in several isoforms, and its longest 200 kDa isoform, predominantly expressed in striated muscle, shows high structural homology to MYPN.\n                    <jats:italic>MYPN<\/jats:italic>\n                    gene mutations are associated with human cardiomyopathies, whereas the role of PALLD in the heart has remained unknown, partly due to embryonic lethality of PALLD knockout mice. In a yeast two-hybrid screening, CARP\/Ankrd1 and FHOD1 were identified as novel interaction partners of PALLD\u2019s N-terminal region. To study the role of PALLD in the heart, we generated conditional (cPKO) and inducible (cPKOi) cardiomyocyte-specific PALLD knockout mice. While cPKO mice exhibited no pathological phenotype, ablation of PALLD in adult cPKOi mice caused progressive cardiac dilation and systolic dysfunction, associated with reduced cardiomyocyte contractility, intercalated disc abnormalities, and fibrosis, demonstrating that PALLD is essential for normal cardiac function. Double cPKO and MYPN knockout (MKO) mice exhibited a similar phenotype as MKO mice, suggesting that MYPN does not compensate for the loss of PALLD in cPKO mice. Altered transcript levels of\n                    <jats:italic>MYPN<\/jats:italic>\n                    and\n                    <jats:italic>PALLD<\/jats:italic>\n                    isoforms were found in myocardial tissue from human dilated and ischemic cardiomyopathy patients, whereas their protein expression levels were unaltered.\n                  <\/jats:p>","DOI":"10.7554\/elife.78629","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T09:01:07Z","timestamp":1678957267000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.78629","source":"Crossref","is-referenced-by-count":10,"title":["Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities"],"prefix":"10.7554","volume":"12","author":[{"given":"Giuseppina","family":"Mastrototaro","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01ynf4891","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Milan-Bicocca","place":["Milan, Italy"]},{"id":[{"id":"https:\/\/ror.org\/05d538656","id-type":"ROR","asserted-by":"publisher"}],"name":"IRCCS Humanitas Research Hospital","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Carullo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05d538656","id-type":"ROR","asserted-by":"publisher"}],"name":"IRCCS Humanitas Research Hospital","place":["Milan, Italy"]},{"id":[{"id":"https:\/\/ror.org\/02dr63s31","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Genetic and Biomedical Research, National Research Council, Milan unit","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0168r3w48","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California, San Diego","place":["La Jolla, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Scellini","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jr1s763","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental and Clinical Medicine, University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Piroddi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jr1s763","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental and Clinical Medicine, University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Nemska","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05d538656","id-type":"ROR","asserted-by":"publisher"}],"name":"IRCCS Humanitas Research Hospital","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmela","family":"Filomena","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05d538656","id-type":"ROR","asserted-by":"publisher"}],"name":"IRCCS Humanitas Research Hospital","place":["Milan, Italy"]},{"id":[{"id":"https:\/\/ror.org\/02dr63s31","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Genetic and Biomedical Research, National Research Council, Milan unit","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-2094","authenticated-orcid":true,"given":"Simone","family":"Serio","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05d538656","id-type":"ROR","asserted-by":"publisher"}],"name":"IRCCS Humanitas Research Hospital","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A","family":"Otey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0130frc33","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill","place":["Chapel Hill, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tesi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jr1s763","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental and Clinical Medicine, University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Emrich","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cvxnb49","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cardiac Surgery, Goethe University","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0801-3773","authenticated-orcid":true,"given":"Wolfgang A","family":"Linke","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00pd74e08","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Physiology II, University of M\u00fcnster","place":["M\u00fcnster, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Poggesi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04jr1s763","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental and Clinical Medicine, University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-5069","authenticated-orcid":true,"given":"Simona","family":"Boncompagni","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00qjgza05","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, Imaging and Clinical Sciences and Center for Advanced Studies and Technology, University G. d'Annunzio","place":["Chieti, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-5034","authenticated-orcid":true,"given":"Marie-Louise","family":"Bang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05d538656","id-type":"ROR","asserted-by":"publisher"}],"name":"IRCCS Humanitas Research Hospital","place":["Milan, Italy"]},{"id":[{"id":"https:\/\/ror.org\/02dr63s31","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Genetic and Biomedical Research, National Research Council, Milan unit","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1172\/JCI7605","article-title":"Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart","volume":"104","author":"Abel","year":"1999","journal-title":"The Journal of Clinical Investigation"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ejcb.2014.11.003","article-title":"Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres","volume":"94","author":"Al Haj","year":"2015","journal-title":"European Journal of Cell Biology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.ijcard.2010.08.004","article-title":"Analysis of the Z-disc genes PDLIM3 and MYPN in patients with hypertrophic cardiomyopathy","volume":"145","author":"Bagnall","year":"2010","journal-title":"International Journal of Cardiology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1083\/jcb.153.2.413","article-title":"Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-Band protein assemblies","volume":"153","author":"Bang","year":"2001","journal-title":"The Journal of Cell Biology"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093638","article-title":"The muscle ankyrin repeat proteins carp, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload","volume":"9","author":"Bang","year":"2014","journal-title":"PLOS ONE"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"H181","DOI":"10.1152\/ajpheart.00562.2021","article-title":"Understanding the molecular basis of cardiomyopathy","volume":"322","author":"Bang","year":"2022","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.2741\/3972","article-title":"From myofibril to membrane; the transitional junction at the intercalated disc","volume":"17","author":"Bennett","year":"2012","journal-title":"Frontiers in Bioscience"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/273936","article-title":"Induction of ankrd1 in dilated cardiomyopathy correlates with the heart failure progression","volume":"2015","author":"Bogomolovas","year":"2015","journal-title":"BioMed Research International"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1091\/mbc.e08-07-0783","article-title":"Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures","volume":"20","author":"Boncompagni","year":"2009","journal-title":"Molecular Biology of the Cell"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"21996","DOI":"10.1073\/pnas.0911496106","article-title":"Characterization and temporal development of cores in a mouse model of malignant hyperthermia","volume":"106","author":"Boncompagni","year":"2009","journal-title":"PNAS"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ejcb.2006.02.009","article-title":"The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk","volume":"85","author":"Borrmann","year":"2006","journal-title":"European Journal of Cell Biology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/cm.10173","article-title":"Palladin is a novel binding partner for Ena\/VASP family members","volume":"58","author":"Boukhelifa","year":"2004","journal-title":"Cell Motility and the Cytoskeleton"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1742-4658.2005.05036.x","article-title":"The proline-rich protein palladin is a binding partner for profilin","volume":"273","author":"Boukhelifa","year":"2006","journal-title":"The FEBS Journal"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1023\/A:1025438000942","article-title":"Gender mediated cardiac protection from adverse ventricular remodeling is abolished by ovariectomy","volume":"251","author":"Brower","year":"2003","journal-title":"Molecular and Cellular Biochemistry"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1161\/01.RES.0000218041.41932.e3","article-title":"Cardiomyocyte-Specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves","volume":"98","author":"Chen","year":"2006","journal-title":"Circulation Research"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.017055","article-title":"Knockout of SORBS2 protein disrupts the structural integrity of intercalated disc and manifests features of arrhythmogenic cardiomyopathy","volume":"9","author":"Ding","year":"2020","journal-title":"Journal of the American Heart Association"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"6222","DOI":"10.1074\/jbc.M707694200","article-title":"Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin","volume":"283","author":"Dixon","year":"2008","journal-title":"The Journal of Biological Chemistry"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.cardiores.2004.03.027","article-title":"Gender modulates cardiac phenotype development in genetically modified mice","volume":"63","author":"Du","year":"2004","journal-title":"Cardiovascular Research"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/cvr\/cvm015","article-title":"Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy","volume":"77","author":"Duboscq-Bidot","year":"2008","journal-title":"Cardiovascular Research"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1002\/ar.22984","article-title":"The formin FHOD1 in cardiomyocytes","volume":"297","author":"Dwyer","year":"2014","journal-title":"Anatomical Record"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006780","article-title":"Genetic compensation: a phenomenon in search of mechanisms","volume":"13","author":"El-Brolosy","year":"2017","journal-title":"PLOS Genetics"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/ki.2008.486","article-title":"Palladin is a dynamic actin-associated protein in podocytes","volume":"75","author":"Endlich","year":"2009","journal-title":"Kidney International"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/jcsm.12486","article-title":"Myopalladin promotes muscle growth through modulation of the serum response factor pathway","volume":"11","author":"Filomena","year":"2020","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58313","article-title":"Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload","volume":"10","author":"Filomena","year":"2021","journal-title":"eLife"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejcb.2005.11.003","article-title":"The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins","volume":"85","author":"Franke","year":"2006","journal-title":"European Journal of Cell Biology"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12868","article-title":"Local microrna delivery targets palladin and prevents metastatic breast cancer","volume":"7","author":"Gilam","year":"2016","journal-title":"Nature Communications"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1242\/jcs.03076","article-title":"Palladin binds to eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells","volume":"119","author":"Goicoechea","year":"2006","journal-title":"Journal of Cell Science"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/onc.2008.408","article-title":"Palladin contributes to invasive motility in human breast cancer cells","volume":"28","author":"Goicoechea","year":"2009","journal-title":"Oncogene"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010347","article-title":"Isoform-specific upregulation of palladin in human and murine pancreas tumors","volume":"5","author":"Goicoechea","year":"2010","journal-title":"PLOS ONE"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1817-3","article-title":"Computer-aided assessment of the extra-cellular matrix during pancreatic carcinogenesis: a pilot study","volume":"17","author":"Grizzi","year":"2019","journal-title":"Journal of Translational Medicine"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1042\/BJ20151050","article-title":"Actin polymerization is stimulated by actin cross-linking protein palladin","volume":"473","author":"Gurung","year":"2016","journal-title":"The Biochemical Journal"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/CIRCRESAHA.111.300105","article-title":"Crucial role for Ca2 (+) \/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation","volume":"112","author":"Hamdani","year":"2013","journal-title":"Circulation Research"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/labinvest.2014.54","article-title":"Rna-Sequencing analysis reveals new alterations in cardiomyocyte cytoskeletal genes in patients with heart failure","volume":"94","author":"Herrer","year":"2014","journal-title":"Laboratory Investigation; a Journal of Technical Methods and Pathology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00395-010-0101-8","article-title":"Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death","volume":"105","author":"Hirschy","year":"2010","journal-title":"Basic Research in Cardiology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1161\/01.RES.0000261351.54147.de","article-title":"Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration","volume":"100","author":"Jin","year":"2007","journal-title":"Circulation Research"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012823","article-title":"The actin associated protein palladin is important for the early smooth muscle cell differentiation","volume":"5","author":"Jin","year":"2010","journal-title":"PLOS ONE"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s10974-011-9246-9","article-title":"The actin associated protein palladin in smooth muscle and in the development of diseases of the cardiovasculature and in cancer","volume":"32","author":"Jin","year":"2011","journal-title":"Journal of Muscle Research and Cell Motility"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1128\/MCB.06212-11","article-title":"MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F","volume":"32","author":"Jurmeister","year":"2012","journal-title":"Molecular and Cellular Biology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1538\/expanim.55.137","article-title":"High-efficiency CAG-flpe deleter mice in C57BL\/6J background","volume":"55","author":"Kanki","year":"2006","journal-title":"Experimental Animals"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2018.e00514","article-title":"Altered regulation of cardiac ankyrin repeat protein in heart failure","volume":"4","author":"Kempton","year":"2018","journal-title":"Heliyon"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1113\/jphysiol.2005.101428","article-title":"Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform","volume":"571","author":"Kondo","year":"2006","journal-title":"The Journal of Physiology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/s0891-0618(02)00102-3","article-title":"Calpain 3 is expressed in astrocytes of rat and microcebus brain","volume":"25","author":"K\u00f6nig","year":"2003","journal-title":"Journal of Chemical Neuroanatomy"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1161\/01.RES.0000156274.72390.2c","article-title":"Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure","volume":"96","author":"Kostetskii","year":"2005","journal-title":"Circulation Research"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1093\/cvr\/cvt144","article-title":"Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts","volume":"99","author":"K\u00f6tter","year":"2013","journal-title":"Cardiovascular Research"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.yjmcc.2010.10.025","article-title":"Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle","volume":"50","author":"Kreutziger","year":"2011","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1359\/JBMR.050915","article-title":"Four and half lim protein 2 (FHL2) stimulates osteoblast differentiation","volume":"21","author":"Lai","year":"2006","journal-title":"Journal of Bone and Mineral Research"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"4322","DOI":"10.1111\/j.1742-4658.2010.07820.x","article-title":"A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-\u03bab pathway in skeletal muscle","volume":"277","author":"Laure","year":"2010","journal-title":"The FEBS Journal"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1242\/jcs.098640","article-title":"Loss of \u03b1T-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia","volume":"125","author":"Li","year":"2012","journal-title":"Journal of Cell Science"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102695","article-title":"Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy","volume":"53","author":"Li","year":"2020","journal-title":"EBioMedicine"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141532","article-title":"PALLD mutation in a european family conveys a stromal predisposition for familial pancreatic cancer","volume":"6","author":"Liotta","year":"2021","journal-title":"JCI Insight"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1093\/cvr\/cvab328","article-title":"Titin (TTN): from molecule to modifications, mechanics, and medical significance","volume":"118","author":"Loescher","year":"2022","journal-title":"Cardiovascular Research"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.mcn.2004.12.002","article-title":"Disruption of palladin results in neural tube closure defects in mice","volume":"29","author":"Luo","year":"2005","journal-title":"Molecular and Cellular Neurosciences"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.febslet.2004.12.009","article-title":"Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities","volume":"579","author":"Madrid","year":"2005","journal-title":"FEBS Letters"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1093\/cvr\/cvv156","article-title":"Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers","volume":"107","author":"Mastrototaro","year":"2015","journal-title":"Cardiovascular Research"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/ejhg.2012.173","article-title":"Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy","volume":"21","author":"Meyer","year":"2013","journal-title":"European Journal of Human Genetics"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.jmb.2003.09.012","article-title":"The muscle ankyrin repeat proteins: CARP, ankrd2\/arpp and DARP as a family of titin filament-based stress response molecules","volume":"333","author":"Miller","year":"2003","journal-title":"Journal of Molecular Biology"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1091\/mbc.12.10.3060","article-title":"Characterization of human palladin, a microfilament-associated protein","volume":"12","author":"Mykk\u00e4nen","year":"2001","journal-title":"Molecular Biology of the Cell"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1161\/01.CIR.0000135591.37759.AF","article-title":"Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy","volume":"110","author":"Nagueh","year":"2004","journal-title":"Circulation"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1093\/hmg\/9.18.2761","article-title":"Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma","volume":"9","author":"Norgett","year":"2000","journal-title":"Human Molecular Genetics"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/cm.20385","article-title":"Cytoplasmic ig-domain proteins: cytoskeletal regulators with a role in human disease","volume":"66","author":"Otey","year":"2009","journal-title":"Cell Motility and the Cytoskeleton"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1083\/jcb.150.3.643","article-title":"Characterization of palladin, a novel protein localized to stress fibers and cell adhesions","volume":"150","author":"Parast","year":"2000","journal-title":"The Journal of Cell Biology"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/87920","article-title":"Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy","volume":"7","author":"Pashmforoush","year":"2001","journal-title":"Nature Medicine"},{"key":"bib63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030516","article-title":"Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism","volume":"3","author":"Pogue-Geile","year":"2006","journal-title":"PLOS Medicine"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1093\/hmg\/dds022","article-title":"Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations","volume":"21","author":"Purevjav","year":"2012","journal-title":"Human Molecular Genetics"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1242\/jcs.02825","article-title":"Identification of palladin isoforms and characterization of an isoform-specific interaction between lasp-1 and palladin","volume":"119","author":"Rachlin","year":"2006","journal-title":"Journal of Cell Science"},{"key":"bib66","article-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2021","unstructured":"R Development Core Team. 2021. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. https:\/\/www.r-project.org\/index.html."},{"key":"bib67","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.febslet.2004.04.006","article-title":"Molecular analysis of the interaction between palladin and alpha-actinin","volume":"566","author":"R\u00f6nty","year":"2004","journal-title":"FEBS Letters"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.yexcr.2005.06.026","article-title":"Involvement of palladin and alpha-actinin in targeting of the abl\/arg kinase adaptor argbp2 to the actin cytoskeleton","volume":"310","author":"R\u00f6nty","year":"2005","journal-title":"Experimental Cell Research"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1016\/j.yexcr.2007.04.030","article-title":"Palladin interacts with SH3 domains of SPIN90 and src and is required for src-induced cytoskeletal remodeling","volume":"313","author":"R\u00f6nty","year":"2007","journal-title":"Experimental Cell Research"},{"key":"bib70","doi-asserted-by":"publisher","DOI":"10.20517\/jca.2021.30","article-title":"Effects of tamoxifen inducible mercremer on gene expression in cardiac myocytes in mice","volume":"2","author":"Rouhi","year":"2022","journal-title":"The Journal of Cardiovascular Aging"},{"key":"bib71","article-title":"RStudio: integrated development for R","author":"RStudio Team","year":"2020","unstructured":"RStudio Team. 2020. RStudio: integrated development for R. Boston, USA: RStudio. http:\/\/www.rstudio.com\/."},{"key":"bib72","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/cm.21523","article-title":"Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice","volume":"76","author":"Sanematsu","year":"2019","journal-title":"Cytoskeleton"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1242\/jcs.126706","article-title":"FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers","volume":"126","author":"Sch\u00f6nichen","year":"2013","journal-title":"Journal of Cell Science"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1161\/CIRCULATIONAHA.106.634469","article-title":"Alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture","volume":"114","author":"Sheikh","year":"2006","journal-title":"Circulation"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1093\/cvr\/cvx151","article-title":"Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies","volume":"113","author":"Sikkel","year":"2017","journal-title":"Cardiovascular Research"},{"key":"bib76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040164","article-title":"Palladin mutation causes familial pancreatic cancer: absence in european families","volume":"4","author":"Slater","year":"2007","journal-title":"PLOS Medicine"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible cre protein","volume":"89","author":"Sohal","year":"2001","journal-title":"Circulation Research"},{"key":"bib78","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-5213-9","article-title":"Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure","volume":"19","author":"Sweet","year":"2018","journal-title":"BMC Genomics"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1242\/jcs.00769","article-title":"Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation","volume":"116","author":"Takeya","year":"2003","journal-title":"Journal of Cell Science"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1161\/01.cir.94.5.1109","article-title":"Transthoracic echocardiography in models of cardiac disease in the mouse","volume":"94","author":"Tanaka","year":"1996","journal-title":"Circulation"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1093\/cvr\/cvw259","article-title":"Refining the molecular organization of the cardiac intercalated disc","volume":"113","author":"Vermij","year":"2017","journal-title":"Cardiovascular Research"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1128\/MCB.01454-08","article-title":"A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies","volume":"29","author":"von Nandelstadh","year":"2009","journal-title":"Molecular and Cellular Biology"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1091\/mbc.E13-11-0667","article-title":"Actin-Associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton","volume":"25","author":"von Nandelstadh","year":"2014","journal-title":"Molecular Biology of the Cell"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1002\/dvdy.21755","article-title":"Comparative expression analysis of the murine palladin isoforms","volume":"237","author":"Wang","year":"2008","journal-title":"Developmental Dynamics"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00018-013-1374-5","article-title":"Cardiomyocyte growth and sarcomerogenesis at the intercalated disc","volume":"71","author":"Wilson","year":"2014","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.1242\/jcs.137026","article-title":"The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse","volume":"126","author":"Yamamoto","year":"2013","journal-title":"Journal of Cell Science"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1161\/CIRCULATIONAHA.113.003863","article-title":"Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support","volume":"129","author":"Yang","year":"2014","journal-title":"Circulation"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1093\/emboj\/17.6.1614","article-title":"Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin","volume":"17","author":"Young","year":"1998","journal-title":"The EMBO Journal"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"7522","DOI":"10.1128\/MCB.00728-07","article-title":"Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy","volume":"27","author":"Zemljic-Harpf","year":"2007","journal-title":"Molecular and Cellular Biology"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"19807","DOI":"10.1074\/jbc.274.28.19807","article-title":"Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C","volume":"274","author":"Zhou","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/S0006-291X(02)00387-X","article-title":"Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure","volume":"293","author":"Zolk","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/78629\/elife-78629-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/78629\/elife-78629-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/78629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:04:31Z","timestamp":1697058271000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/78629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":91,"alternative-id":["10.7554\/eLife.78629"],"URL":"https:\/\/doi.org\/10.7554\/elife.78629","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.04.29.489866","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.04.29.489866","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.78629.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.78629.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.78629.sa1","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,16]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e78629"}}