{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:03:31Z","timestamp":1792609411444,"version":"4.5.0"},"reference-count":76,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","award":["MH052804"],"award-info":[{"award-number":["MH052804"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"crossref","award":["ALTF 803-2017"],"award-info":[{"award-number":["ALTF 803-2017"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001167","name":"Larry L. Hillblom Foundation","doi-asserted-by":"crossref","award":["2020-A-016-FEL"],"award-info":[{"award-number":["2020-A-016-FEL"]}],"id":[{"id":"10.13039\/100001167","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,10,6]]},"abstract":"<jats:p>\n                    At CA1\u2192subiculum synapses, alternatively spliced neurexin-1 (Nrxn1\n                    <jats:sup>SS4+<\/jats:sup>\n                    ) and neurexin-3 (Nrxn3\n                    <jats:sup>SS4+<\/jats:sup>\n                    ) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation. Nrxn1\n                    <jats:sup>SS4+<\/jats:sup>\n                    and Nrxn3\n                    <jats:sup>SS4+<\/jats:sup>\n                    act by binding to secreted cerebellin-2 (Cbln2) that in turn activates postsynaptic GluD1 receptors. Whether neurexin-Cbln2-GluD1 signaling has additional functions besides regulating NMDA- and AMPA-receptors, and whether such signaling performs similar roles at other synapses, however, remains unknown. Here, we demonstrate using constitutive Cbln2 deletions in mice that at CA1\u2192subiculum synapses, Cbln2 performs no additional developmental roles besides regulating AMPA- and NMDA-receptors. Moreover, low-level expression of functionally redundant Cbln1 did not compensate for a possible synapse-formation function of Cbln2 at CA1\u2192subiculum synapses. In exploring the generality of these findings, we examined the prefrontal cortex where Cbln2 was recently implicated in spinogenesis, and the cerebellum where Cbln1 is known to regulate parallel-fiber synapses. In the prefrontal cortex, Nrxn1\n                    <jats:sup>SS4+<\/jats:sup>\n                    -Cbln2 signaling selectively controlled NMDA-receptors without affecting spine or synapse numbers, whereas Nrxn3\n                    <jats:sup>SS4+<\/jats:sup>\n                    -Cbln2 signaling had no apparent role. In the cerebellum, conversely, Nrxn3\n                    <jats:sup>SS4+<\/jats:sup>\n                    -Cbln1 signaling regulated AMPA-receptors, whereas now Nrxn1\n                    <jats:sup>SS4+<\/jats:sup>\n                    -Cbln1 signaling had no manifest effect. Thus, Nrxn1\n                    <jats:sup>SS4+<\/jats:sup>\n                    - and Nrxn3\n                    <jats:sup>SS4+<\/jats:sup>\n                    -Cbln1\/2 signaling complexes differentially control NMDA- and AMPA-receptors in different synapses in diverse neural circuits without regulating synapse or spine formation.\n                  <\/jats:p>","DOI":"10.7554\/elife.78649","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T08:00:33Z","timestamp":1665129633000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.78649","source":"Crossref","is-referenced-by-count":34,"title":["Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8497-3154","authenticated-orcid":true,"given":"Jinye","family":"Dai","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"publisher"}],"name":"Howard Hughes Medical Institute, Stanford University","place":["Stanford, United States"]},{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Cellular Physiology, Stanford University","place":["Stanford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-7424","authenticated-orcid":true,"given":"Kif","family":"Liakath-Ali","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Cellular Physiology, Stanford University","place":["Stanford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Rose","family":"Golf","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Cellular Physiology, Stanford University","place":["Stanford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3361-9275","authenticated-orcid":true,"given":"Thomas C","family":"S\u00fcdhof","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"publisher"}],"name":"Howard Hughes Medical Institute, Stanford University","place":["Stanford, United States"]},{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Cellular Physiology, Stanford University","place":["Stanford, United 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