{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:19:29Z","timestamp":1791368369298,"version":"4.3.1"},"reference-count":95,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Ministry of Science and Technology of China","award":["2016YFD0100505"],"award-info":[{"award-number":["2016YFD0100505"]}]},{"name":"National Transgenic New Species Breeding Major Project of China","award":["2016ZX08005-003-004"],"award-info":[{"award-number":["2016ZX08005-003-004"]}]},{"name":"National Major Project of Breeding of China","award":["2018YFD0100403"],"award-info":[{"award-number":["2018YFD0100403"]}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,6,22]]},"abstract":"<jats:p>\n                    Mechanisms for cellular detoxification of drug compounds are of significant interest in human health. Cyclosporine A (CsA) and tacrolimus (FK506) are widely known antifungal and immunosuppressive microbial natural products. However, both compounds can result in significant side effects when used as immunosuppressants. The insect pathogenic fungus\n                    <jats:italic>Beauveria bassiana<\/jats:italic>\n                    shows resistance to CsA and FK506. However, the mechanisms underlying the resistance have remained unknown. Here, we identify a P4-ATPase gene,\n                    <jats:italic>BbCRPA<\/jats:italic>\n                    , from the fungus, which confers resistance\n                    <jats:italic>via<\/jats:italic>\n                    a unique vesicle mediated transport pathway that targets the compounds into detoxifying vacuoles. Interestingly, the expression of\n                    <jats:italic>BbCRPA<\/jats:italic>\n                    in plants promotes resistance to the phytopathogenic fungus\n                    <jats:italic>Verticillium dahliae<\/jats:italic>\n                    via detoxification of the mycotoxin cinnamyl acetate using a similar pathway. Our data reveal a new function for a subclass of P4-ATPases in cell detoxification. The P4-ATPases conferred cross-species resistance can be exploited for plant disease control and human health protection.\n                  <\/jats:p>","DOI":"10.7554\/elife.79179","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T14:01:56Z","timestamp":1687528916000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.79179","source":"Crossref","is-referenced-by-count":11,"title":["Cell detoxification of secondary metabolites by P4-ATPase-mediated vesicle transport"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9293-6233","authenticated-orcid":true,"given":"Yujie","family":"Li","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01kj4z117","id-type":"ROR","asserted-by":"publisher"}],"name":"Biotechnology Research Center, Southwest University","place":["Chongqing, 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