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The precise role(s) of the Fe protein Fe\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    cluster in some of these processes remains ill-defined. Herein, we report crystallographic data demonstrating ATP-dependent chalcogenide exchange at the Fe\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    cluster of the nitrogenase Fe protein when potassium selenocyanate is used as the selenium source, an unexpected result as the Fe protein cluster is not traditionally perceived as a site of substrate binding within nitrogenase. The observed chalcogenide exchange illustrates that this Fe\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    cluster is capable of core substitution reactions under certain conditions, adding to the Fe protein\u2019s repertoire of unique properties.\n                  <\/jats:p>","DOI":"10.7554\/elife.79311","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T06:15:14Z","timestamp":1659075314000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.79311","source":"Crossref","is-referenced-by-count":12,"title":["Selenocyanate derived Se-incorporation into the nitrogenase Fe protein cluster"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-9203","authenticated-orcid":true,"given":"Trixia 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