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Here, we identify a new role for Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 in mammalian proprioception. RNAscope analysis and in vitro patch-clamp recordings in genetically identified mouse proprioceptors show ubiquitous channel expression and significant contributions to intrinsic excitability. Notably, genetic deletion of Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 in sensory neurons caused profound and visible motor coordination deficits in conditional knockout mice of both sexes, similar to conditional Piezo2-knockout animals, suggesting that this channel is a major contributor to sensory proprioceptive transmission. Ex vivo muscle afferent recordings from conditional knockout mice found that loss of Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 leads to inconsistent and unreliable proprioceptor firing characterized by action potential failures during static muscle stretch; conversely, afferent responses to dynamic vibrations were unaffected. This suggests that while a combination of Piezo2 and other Na\n                    <jats:sub>V<\/jats:sub>\n                    isoforms is sufficient to elicit activity in response to transient stimuli, Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 is required for transmission of receptor potentials generated during sustained muscle stretch. Impressively, recordings from afferents of heterozygous conditional knockout animals were similarly impaired, and heterozygous conditional knockout mice also exhibited motor behavioral deficits. Thus, Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 haploinsufficiency in sensory neurons impairs both proprioceptor function and motor behaviors. Importantly, human patients harboring Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 loss-of-function mutations often present with motor delays and ataxia; therefore, our data suggest that sensory neuron dysfunction contributes to the clinical manifestations of neurological disorders in which Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 function is compromised. Collectively, we present the first evidence that Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 is essential for mammalian proprioceptive signaling and behaviors.\n                  <\/jats:p>","DOI":"10.7554\/elife.79917","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T08:00:19Z","timestamp":1666598419000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.79917","source":"Crossref","is-referenced-by-count":35,"title":["NaV1.1 is essential for proprioceptive signaling and motor behaviors"],"prefix":"10.7554","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-4577","authenticated-orcid":true,"given":"Cyrrus M","family":"Espino","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California, Davis","place":["Davis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0057-2047","authenticated-orcid":true,"given":"Cheyanne M","family":"Lewis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California, Davis","place":["Davis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Ortiz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qyvz380","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Science, San Jose State University","place":["San Jose, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miloni S","family":"Dalal","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05vt9qd57","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers University","place":["Newark, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Garlapalli","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Undergraduate Program in Psychology, University of California, Davis","place":["Davis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylee M","family":"Wells","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046dg4z72","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology Course, Marine Biological Laboratory","place":["Woods Hole, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darik A","family":"O'Neil","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046dg4z72","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology Course, Marine Biological Laboratory","place":["Woods Hole, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-5533","authenticated-orcid":true,"given":"Katherine A","family":"Wilkinson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qyvz380","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Science, San Jose State University","place":["San Jose, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0090-6286","authenticated-orcid":true,"given":"Theanne N","family":"Griffith","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Physiology and Membrane Biology, University of California, Davis","place":["Davis, United States"]},{"id":[{"id":"https:\/\/ror.org\/046dg4z72","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology Course, Marine Biological Laboratory","place":["Woods Hole, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1085\/jgp.201511492","article-title":"The hitchhiker\u2019s guide to the voltage-gated sodium channel galaxy","volume":"147","author":"Ahern","year":"2016","journal-title":"The Journal of General Physiology"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1186\/s12990-015-0063-9","article-title":"Nav\u03b24 regulates fast resurgent sodium currents and excitability in sensory neurons","volume":"11","author":"Barbosa","year":"2015","journal-title":"Molecular Pain"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrn2148","article-title":"The action potential in mammalian central neurons","volume":"8","author":"Bean","year":"2007","journal-title":"Nature Reviews. 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