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However, the functions of the m\n                    <jats:sup>6<\/jats:sup>\n                    A epitranscriptome in the visual system remain unclear. In this study, using a retina-specific conditional knockout mouse model, we show that retinas deficient in\n                    <jats:italic>Mettl3<\/jats:italic>\n                    , the core component of the m\n                    <jats:sup>6<\/jats:sup>\n                    A methyltransferase complex, exhibit structural and functional abnormalities beginning at the end of retinogenesis. Immunohistological and single-cell RNA sequencing (scRNA-seq) analyses of retinogenesis processes reveal that retinal progenitor cells (RPCs) and M\u00fcller glial cells are the two cell types primarily affected by\n                    <jats:italic>Mettl3<\/jats:italic>\n                    deficiency. Integrative analyses of scRNA-seq and MeRIP-seq data suggest that m\n                    <jats:sup>6<\/jats:sup>\n                    A fine-tunes the transcriptomic transition from RPCs to M\u00fcller cells by promoting the degradation of RPC transcripts, the disruption of which leads to abnormalities in late retinogenesis and likely compromises the glial functions of M\u00fcller cells. Overexpression of m\n                    <jats:sup>6<\/jats:sup>\n                    A-regulated RPC transcripts in late RPCs partially recapitulates the\n                    <jats:italic>Mettl3<\/jats:italic>\n                    -deficient retinal phenotype. Collectively, our study reveals an epitranscriptomic mechanism governing progenitor-to-glial cell transition during late retinogenesis, which is essential for the homeostasis of the mature retina. The mechanism revealed in this study might also apply to other nervous systems.\n                  <\/jats:p>","DOI":"10.7554\/elife.79994","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T07:15:26Z","timestamp":1668410126000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.79994","source":"Crossref","is-referenced-by-count":18,"title":["m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina"],"prefix":"10.7554","volume":"11","author":[{"given":"Yanling","family":"Xin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0064kty71","id-type":"ROR","asserted-by":"publisher"}],"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science","place":["Guangzhou, 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