{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:19:48Z","timestamp":1790155188963,"version":"4.0.1"},"reference-count":73,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","award":["RO1DC015783"],"award-info":[{"award-number":["RO1DC015783"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","award":["F32DC017343"],"award-info":[{"award-number":["F32DC017343"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,3,10]]},"abstract":"<jats:p>\n                    Hair cells of the inner ear are particularly sensitive to changes in mitochondria, the subcellular organelles necessary for energy production in all eukaryotic cells. There are over 30 mitochondrial deafness genes, and mitochondria are implicated in hair cell death following noise exposure, aminoglycoside antibiotic exposure, as well as in age-related hearing loss. However, little is known about the basic aspects of hair cell mitochondrial biology. Using hair cells from the zebrafish lateral line as a model and serial block-face scanning electron microscopy, we have quantifiably characterized a unique hair cell mitochondrial phenotype that includes (1) a high mitochondrial volume and (2) specific mitochondrial architecture: multiple small mitochondria apically, and a reticular mitochondrial network basally. This phenotype develops gradually over the lifetime of the hair cell. Disrupting this mitochondrial phenotype with a mutation in\n                    <jats:italic>opa1<\/jats:italic>\n                    impacts mitochondrial health and function. While hair cell activity is not required for the high mitochondrial volume, it shapes the mitochondrial architecture, with mechanotransduction necessary for all patterning, and synaptic transmission necessary for the development of mitochondrial networks. These results demonstrate the high degree to which hair cells regulate their mitochondria for optimal physiology and provide new insights into mitochondrial deafness.\n                  <\/jats:p>","DOI":"10.7554\/elife.80468","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T11:00:23Z","timestamp":1678705223000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.80468","source":"Crossref","is-referenced-by-count":21,"title":["Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-2004","authenticated-orcid":true,"given":"Andrea","family":"McQuate","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Structure, University of Washington","place":["Seattle, United States"]},{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Otolaryngology-HNS, University of Washington","place":["Seattle, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmon","family":"Knecht","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Structure, University of Washington","place":["Seattle, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5342-5841","authenticated-orcid":true,"given":"David W","family":"Raible","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Structure, University of Washington","place":["Seattle, United States"]},{"id":[{"id":"https:\/\/ror.org\/00cvxb145","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Otolaryngology-HNS, University of Washington","place":["Seattle, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1152\/jn.00019.2010","article-title":"Calcium balance and mechanotransduction in rat cochlear hair cells","volume":"104","author":"Beurg","year":"2010","journal-title":"Journal of Neurophysiology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.heares.2013.01.006","article-title":"The mitochondrion: a perpetrator of acquired hearing loss","volume":"303","author":"B\u00f6ttger","year":"2013","journal-title":"Hearing Research"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.cmet.2014.11.003","article-title":"Activation of SIRT3 by the NAD","volume":"20","author":"Brown","year":"2014","journal-title":"Cell Metabolism"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.101696","article-title":"3D cellular reconstruction of cortical glia and parenchymal morphometric analysis from serial block-face electron microscopy of juvenile rat","volume":"183","author":"Cal\u00ec","year":"2019","journal-title":"Progress in Neurobiology"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038011","article-title":"TrakEM2 software for neural circuit reconstruction","volume":"7","author":"Cardona","year":"2012","journal-title":"PLOS ONE"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of drp1 to mitochondria","volume":"105","author":"Cereghetti","year":"2008","journal-title":"PNAS"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1079\/PNS2004335","article-title":"The role of calcium and calcium\/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis","volume":"63","author":"Chin","year":"2004","journal-title":"The Proceedings of the Nutrition Society"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.embor.7401062","article-title":"Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death","volume":"8","author":"Cribbs","year":"2007","journal-title":"EMBO Reports"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1523\/JNEUROSCI.07-09-02821.1987","article-title":"Adaptation of mechanoelectrical transduction in hair cells of the bullfrog\u2019s sacculus","volume":"7","author":"Eatock","year":"1987","journal-title":"The Journal of Neuroscience"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"9703","DOI":"10.1523\/JNEUROSCI.0281-14.2014","article-title":"Er-Mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage","volume":"34","author":"Esterberg","year":"2014","journal-title":"The Journal of Neuroscience"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.1172\/JCI84939","article-title":"Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death","volume":"126","author":"Esterberg","year":"2016","journal-title":"The Journal of Clinical Investigation"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1523\/JNEUROSCI.2689-16.2017","article-title":"Mitochondria maintain distinct ca2+ pools in cone photoreceptors","volume":"37","author":"Giarmarco","year":"2017","journal-title":"J Neurosci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nature Cell Biology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1083\/jcb.200802164","article-title":"Cam kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology","volume":"182","author":"Han","year":"2008","journal-title":"The Journal of Cell Biology"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98409-7","article-title":"The 3D organisation of mitochondria in primate photoreceptors","volume":"11","author":"Hayes","year":"2021","journal-title":"Sci Rep-Uk"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.36wgq7je5vk5\/v2","volume-title":"Preparation of Biological Tissues for Serial Block Face Scanning Electron Microscopy SBEM V2","author":"J. Deerinck","year":"2022"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.devcel.2012.05.022","article-title":"Kinocilia mediate mechanosensitivity in developing zebrafish hair cells","volume":"23","author":"Kindt","year":"2012","journal-title":"Developmental Cell"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1399-0004.2007.00800.x","article-title":"Mitochondrial deafness","volume":"71","author":"Kokotas","year":"2007","journal-title":"Clinical Genetics"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"13176","DOI":"10.1096\/fj.201901136r","article-title":"Mitochondrial morphology regulates organellar ca 2+ uptake and changes cellular ca 2+ homeostasis","volume":"33","author":"Kowaltowski","year":"2019","journal-title":"FASEB J"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws340","article-title":"Sensorineural hearing loss in OPA1-linked disorders","volume":"136","author":"Leruez","year":"2013","journal-title":"Brain"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00106-019-0662-2","article-title":"Why study inner ear hair cell mitochondria?","volume":"67","author":"Lesus","year":"2019","journal-title":"HNO"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41583-021-00535-8","article-title":"Energy matters: presynaptic metabolism and the maintenance of synaptic transmission","volume":"23","author":"Li","year":"2022","journal-title":"Nature Reviews. Neuroscience"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1152\/jn.00417.2020","article-title":"Metformin alleviates cisplatin-induced ototoxicity by autophagy induction possibly via the AMPK\/FoxO3A pathway","volume":"125","author":"Liang","year":"2021","journal-title":"Journal of Neurophysiology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00415-008-0571-x","article-title":"A phenotypic variation of dominant optic atrophy and deafness (ADOAD) due to a novel OPA1 mutation","volume":"255","author":"Liguori","year":"2008","journal-title":"Journal of Neurology"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111212","article-title":"Mitochondrial fission and fusion: a dynamic role in aging and potential target for age-related disease","volume":"186","author":"Liu","year":"2020","journal-title":"Mechanisms of Ageing and Development"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12264-021-00801-w","article-title":"Aligned organization of synapses and mitochondria in auditory hair cells","volume":"38","author":"Liu","year":"2022","journal-title":"Neuroscience Bulletin"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.77775","article-title":"Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults","volume":"11","author":"Lukasz","year":"2022","journal-title":"eLife"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.21105\/joss.00861","article-title":"UMAP: uniform manifold approximation and projection","volume":"3","author":"McInnes","year":"2018","journal-title":"Journal of Open Source Software"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.tcb.2017.02.006","article-title":"Mitochondrial function and cell size: an allometric relationship","volume":"27","author":"Miettinen","year":"2017","journal-title":"Trends in Cell Biology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1152\/physrev.00022.2011","article-title":"Sirtuin 1 and sirtuin 3: physiological modulators of metabolism","volume":"92","author":"Nogueiras","year":"2012","journal-title":"Physiological Reviews"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"E1040","DOI":"10.1152\/ajpendo.00242.2002","article-title":"Intermittent increases in cytosolic ca2+ stimulate mitochondrial biogenesis in muscle cells","volume":"283","author":"Ojuka","year":"2002","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.bbamcr.2006.04.003","article-title":"Mitochondrial dynamics and disease, OPA1","volume":"1763","author":"Olichon","year":"2006","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1113\/jphysiol.2013.265108","article-title":"In vivo and in vitro biophysical properties of hair cells from the lateral line and inner ear of developing and adult zebrafish","volume":"592","author":"Olt","year":"2014","journal-title":"The Journal of Physiology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/cne.21345","article-title":"Ultrastructural analysis of aminoglycoside-induced hair cell death in the zebrafish lateral line reveals an early mitochondrial response","volume":"502","author":"Owens","year":"2007","journal-title":"The Journal of Comparative Neurology"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235491","article-title":"Sirt3 promotes auditory function in young adult FVB\/nj mice but is dispensable for hearing recovery after noise exposure","volume":"15","author":"Patel","year":"2020","journal-title":"PLOS ONE"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.48550\/arxiv.1201.0490","article-title":"Scikit-Learn: Machine Learning in Python","volume-title":"arXiv","author":"Pedregosa","year":"2012"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1523\/JNEUROSCI.1517-09.2010","article-title":"The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism","volume":"30","author":"Perkins","year":"2010","journal-title":"The Journal of Neuroscience"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"8556","DOI":"10.1523\/JNEUROSCI.2901-19.2020","article-title":"Altered outer hair cell mitochondrial and subsurface cisternae connectomics are candidate mechanisms for hearing loss in mice","volume":"40","author":"Perkins","year":"2020","journal-title":"The Journal of Neuroscience"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.cmet.2015.08.022","article-title":"Calcineurin links mitochondrial elongation with energy metabolism","volume":"22","author":"Pfluger","year":"2015","journal-title":"Cell Metabolism"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"R393","DOI":"10.1152\/ajpregu.00584.2012","article-title":"Mitochondrial morphology transitions and functions: implications for retrograde signaling?","volume":"304","author":"Picard","year":"2013","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"bib42","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.38062","article-title":"Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells","volume":"7","author":"Pickett","year":"2018","journal-title":"eLife"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10162-018-00711-1","article-title":"Water waves to sound waves: using zebrafish to explore hair cell biology","volume":"20","author":"Pickett","year":"2019","journal-title":"Journal of the Association for Research in Otolaryngology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1083\/jcb.74.2.468","article-title":"Mitochondrial growth and division during the cell cycle in HeLa cells","volume":"74","author":"Posakony","year":"1977","journal-title":"The Journal of Cell Biology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/s0378-5955(97)00163-9","article-title":"Energy metabolism in cochlear outer hair cells in vitro","volume":"114","author":"Puschner","year":"1997","journal-title":"Hearing Research"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1126\/science.1225720","article-title":"Mitochondrial network size scaling in budding yeast","volume":"338","author":"Rafelski","year":"2012","journal-title":"Science"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/(sici)1096-9861(20000529)421:23.0.co;2-k","article-title":"Organization of the lateral line system in embryonic zebrafish","volume":"421","author":"Raible","year":"2000","journal-title":"The Journal of Comparative Neurology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.brainresrev.2010.11.004","article-title":"Dynamin-Related protein 1 and mitochondrial fragmentation in neurodegenerative diseases","volume":"67","author":"Reddy","year":"2011","journal-title":"Brain Research Reviews"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.52324\/001c.8285","article-title":"PySAL: a python library of spatial analytical methods","volume":"37","author":"Rey","year":"2007","journal-title":"Review of Regional Studies"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"8261","DOI":"10.1523\/JNEUROSCI.18-20-08261.1998","article-title":"The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells","volume":"18","author":"Ricci","year":"1998","journal-title":"The Journal of Neuroscience"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"7881","DOI":"10.1523\/JNEUROSCI.23-21-07881.2003","article-title":"Glutamate decreases mitochondrial size and movement in primary forebrain neurons","volume":"23","author":"Rintoul","year":"2003","journal-title":"The Journal of Neuroscience"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/jcp.1041360316","article-title":"Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells","volume":"136","author":"Robin","year":"1988","journal-title":"Journal of Cellular Physiology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.devcel.2015.05.025","article-title":"Regeneration of sensory hair cells requires localized interactions between the Notch and Wnt pathways","volume":"34","author":"Romero-Carvajal","year":"2015","journal-title":"Developmental Cell"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nmeth.3360","article-title":"Rapid reverse genetic screening using CRISPR in zebrafish","volume":"12","author":"Shah","year":"2015","journal-title":"Nature Methods"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"17273","DOI":"10.1523\/JNEUROSCI.3005-12.2012","article-title":"Presynaptic Cav1.3 channels regulate synaptic ribbon size and are required for synaptic maintenance in sensory hair cells","volume":"32","author":"Sheets","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10162-021-00798-z","article-title":"How zebrafish can drive the future of genetic-based hearing and balance research","volume":"22","author":"Sheets","year":"2021","journal-title":"Journal of the Association for Research in Otolaryngology"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/s0074-7696(08)61686-1","article-title":"Mitochondrial form and function relationships in vivo: their potential in toxicology and pathology","volume":"83","author":"Smith","year":"1983","journal-title":"International Review of Cytology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/nature02484","article-title":"Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells","volume":"428","author":"S\u00f6llner","year":"2004","journal-title":"Nature"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.mad.2010.04.006","article-title":"Mitochondrial oxidative damage and apoptosis in age-related hearing loss","volume":"131","author":"Someya","year":"2010","journal-title":"Mechanisms of Ageing and Development"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ceca.2004.02.012","article-title":"Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury","volume":"36","author":"Starkov","year":"2004","journal-title":"Cell Calcium"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/s0896-6273(02)01094-2","article-title":"Axonal transport of mitochondria to synapses depends on Milton, a novel Drosophila protein","volume":"36","author":"Stowers","year":"2002","journal-title":"Neuron"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.bbamcr.2006.04.002","article-title":"Mitochondrial dynamics and Ca2+ signaling","volume":"1763","author":"Szabadkai","year":"2006","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib63","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43736","article-title":"Distinct progenitor populations mediate regeneration in the zebrafish lateral line","volume":"8","author":"Thomas","year":"2019","journal-title":"eLife"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1523\/JNEUROSCI.3369-10.2011","article-title":"Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ","volume":"31","author":"Trapani","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.bbabio.2008.05.001","article-title":"Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view","volume":"1777","author":"Twig","year":"2008","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1042\/BST20210798","article-title":"The role of protein acetylation in regulating mitochondrial fusion and fission","volume":"49","author":"Uddin","year":"2021","journal-title":"Biochemical Society Transactions"},{"key":"bib67","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00469","article-title":"Mitochondrial calcium transporters mediate sensitivity to noise-induced losses of hair cells and cochlear synapses","volume":"11","author":"Wang","year":"2018","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"bib68","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48914","article-title":"Synaptic mitochondria regulate hair-cell synapse size and function","volume":"8","author":"Wong","year":"2019","journal-title":"eLife"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.exger.2013.12.006","article-title":"Sirt1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss","volume":"51","author":"Xiong","year":"2014","journal-title":"Experimental Gerontology"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mad.2016.02.003","article-title":"Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis","volume":"155","author":"Yuan","year":"2016","journal-title":"Mechanisms of Ageing and Development"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.toxlet.2021.05.013","article-title":"Modulation of NAD+ biosynthesis activates SIRT1 and resists cisplatin-induced ototoxicity","volume":"349","author":"Zhan","year":"2021","journal-title":"Toxicology Letters"},{"key":"bib72","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03806-8","article-title":"Synaptically silent sensory hair cells in zebrafish are recruited after damage","volume":"9","author":"Zhang","year":"2018","journal-title":"Nature Communications"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.4161\/auto.24135","article-title":"After the banquet","volume":"9","author":"Zhu","year":"2013","journal-title":"Autophagy"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/80468\/elife-80468-v4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/80468\/elife-80468-v4.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/80468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T04:20:55Z","timestamp":1718079655000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/80468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":73,"alternative-id":["10.7554\/eLife.80468"],"URL":"https:\/\/doi.org\/10.7554\/elife.80468","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.06.17.496604","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.06.17.496604","asserted-by":"object"}],"is-supplemented-by":[{"id-type":"accession","id":"4743,4995,263,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"4925,5724,246,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"4774,5185,341,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"4930,5395,267,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"4947,5529,222,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"4953,3852,212,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"5297,5328,323,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"3332,3547,205,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"4623,4852,195,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"5129,5047,160,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"5690,5783,282,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"5232,6593,288,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"5932,6878,248,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"6142,7029,322,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"4836,5799,367,0,1.3","asserted-by":"subject"},{"id-type":"accession","id":"webknossos.org","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.80468.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.80468.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.80468.sa0","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e80468"}}