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Although the origins of macrophages are diverse, some common transcription factors (such as PU.1) are required to ensure proper development of monocytes\/macrophages. Here, we report that the deficiency of\n                    <jats:italic>zbtb14<\/jats:italic>\n                    , a transcription repressor gene belonging to\n                    <jats:italic>ZBTB<\/jats:italic>\n                    family, leads to an aberrant expansion of monocyte\/macrophage population in zebrafish. Mechanistically, Zbtb14 functions as a negative regulator of\n                    <jats:italic>pu.1<\/jats:italic>\n                    , and SUMOylation on a conserved lysine is essential for the repression activity of Zbtb14. Moreover, a serine to phenylalanine mutation found in an acute myeloid leukemia (AML) patient could target ZBTB14 protein to autophagic degradation. Hence,\n                    <jats:italic>ZBTB14<\/jats:italic>\n                    is a newly identified gene implicated in both normal and malignant myelopoiesis.\n                  <\/jats:p>","DOI":"10.7554\/elife.80760","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T06:00:20Z","timestamp":1665122420000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.80760","source":"Crossref","is-referenced-by-count":15,"title":["Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish"],"prefix":"10.7554","volume":"11","author":[{"given":"Yun","family":"Deng","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"publisher"}],"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, 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