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Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring of gene expression is achieved in cancer cells. Here, we have harnessed the power of RNA-seq data from hundreds of patients with oesophageal adenocarcinoma (OAC) or its precursor state Barrett\u2019s oesophagus coupled with open chromatin maps to identify potential enhancer RNAs and their associated enhancer regions in this cancer. We identify ~1000 OAC-specific enhancers and use these data to uncover new cellular pathways that are operational in OAC. Among these are enhancers for\n                    <jats:italic>JUP<\/jats:italic>\n                    ,\n                    <jats:italic>MYBL2<\/jats:italic>\n                    , and\n                    <jats:italic>CCNE1<\/jats:italic>\n                    , and we show that their activity is required for cancer cell viability. We also demonstrate the clinical utility of our dataset for identifying disease stage and patient prognosis. Our data therefore identify an important set of regulatory elements that enhance our molecular understanding of OAC and point to potential new therapeutic directions.\n                  <\/jats:p>","DOI":"10.7554\/elife.80840","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T08:01:48Z","timestamp":1676880108000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.80840","source":"Crossref","is-referenced-by-count":19,"title":["eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-6658","authenticated-orcid":true,"given":"Ibrahim","family":"Ahmed","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027m9bs27","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Hsi","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027m9bs27","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0217-881X","authenticated-orcid":true,"given":"Samuel","family":"Ogden","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027m9bs27","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027m9bs27","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyong","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027m9bs27","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The OCCAMs consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-9552","authenticated-orcid":true,"given":"Andrew D","family":"Sharrocks","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/027m9bs27","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"32270","DOI":"10.18632\/oncotarget.15650","article-title":"Beyond cell-cell adhesion: plakoglobin and the regulation of tumorigenesis and metastasis","volume":"8","author":"Aktary","year":"2017","journal-title":"Oncotarget"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nature12787","article-title":"An atlas of active enhancers across human cell types and tissues","volume":"507","author":"Andersson","year":"2014","journal-title":"Nature"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41576-019-0173-8","article-title":"Determinants of enhancer and promoter activities of regulatory elements","volume":"21","author":"Andersson","year":"2020","journal-title":"Nature Reviews. 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