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Here, we found that\n                    <jats:italic>FOXP2<\/jats:italic>\n                    is overexpressed in human prostate cancer cells and prostate tumors, but its expression is absent in normal prostate epithelial cells and low in benign prostatic hyperplasia.\n                    <jats:italic>FOXP2<\/jats:italic>\n                    is a FOX transcription factor family member and tightly associated with vocal development. To date, little is known regarding the link of\n                    <jats:italic>FOXP2<\/jats:italic>\n                    to prostate cancer. We observed that high\n                    <jats:italic>FOXP2<\/jats:italic>\n                    expression and frequent amplification are significantly associated with high Gleason score. Ectopic expression of\n                    <jats:italic>FOXP2<\/jats:italic>\n                    induces malignant transformation of mouse NIH3T3 fibroblasts and human prostate epithelial cell RWPE-1. Conversely,\n                    <jats:italic>FOXP2<\/jats:italic>\n                    knockdown suppresses the proliferation of prostate cancer cells. Transgenic overexpression of\n                    <jats:italic>FOXP2<\/jats:italic>\n                    in the mouse prostate causes prostatic intraepithelial neoplasia. Overexpression of\n                    <jats:italic>FOXP2<\/jats:italic>\n                    aberrantly activates oncogenic MET signaling and inhibition of MET signaling effectively reverts the\n                    <jats:italic>FOXP2<\/jats:italic>\n                    -induced oncogenic phenotype. CUT&amp;Tag assay identified FOXP2-binding sites located in\n                    <jats:italic>MET<\/jats:italic>\n                    and its associated gene\n                    <jats:italic>HGF<\/jats:italic>\n                    . Additionally, the novel recurrent\n                    <jats:italic>FOXP2-CPED1<\/jats:italic>\n                    fusion identified in prostate tumors results in high expression of truncated FOXP2, which exhibit a similar capacity for malignant transformation. Together, our data indicate that\n                    <jats:italic>FOXP2<\/jats:italic>\n                    is involved in tumorigenicity of prostate.\n                  <\/jats:p>","DOI":"10.7554\/elife.81258","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T07:50:14Z","timestamp":1693900214000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.81258","source":"Crossref","is-referenced-by-count":8,"title":["FOXP2 confers oncogenic effects in prostate cancer"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9099-5835","authenticated-orcid":true,"given":"Xiaoquan","family":"Zhu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jwb5s28","id-type":"ROR","asserted-by":"publisher"}],"name":"The Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, 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