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In this study, we found that the deletion of the myostatin (\n                    <jats:italic>MSTN<\/jats:italic>\n                    ) gene positively regulates the expression of the intestinal tight junction-related genes\n                    <jats:italic>TJP1<\/jats:italic>\n                    and\n                    <jats:italic>OCLN<\/jats:italic>\n                    through the myosin light-chain kinase\/myosin light chain pathway. The intestinal structure of\n                    <jats:italic>\n                      MSTN\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    pigs differed from wild-type, including by the presence of a thicker muscularis and longer plicae. Together, these changes affect the structure of intestinal microbiota. Mice transplanted with the intestinal microbiota of\n                    <jats:italic>\n                      MSTN\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    pigs had myofibers with larger cross-sectional areas and higher fast-twitch glycolytic muscle mass. Microbes responsible for the production of short-chain fatty acids (SCFAs) were enriched in both the\n                    <jats:italic>\n                      MSTN\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    pigs and recipient mice, and SCFAs levels were elevated in the colon contents. We also demonstrated that valeric acid stimulates type IIb myofiber growth by activating the Akt\/mTOR pathway via G protein-coupled receptor 43 and ameliorates dexamethasone-induced muscle atrophy. This is the first study to identify the\n                    <jats:italic>MSTN<\/jats:italic>\n                    gene-gut microbiota-SCFA axis and its regulatory role in fast-twitch glycolytic muscle growth.\n                  <\/jats:p>","DOI":"10.7554\/elife.81858","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T08:00:18Z","timestamp":1681200018000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.81858","source":"Crossref","is-referenced-by-count":37,"title":["Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis"],"prefix":"10.7554","volume":"12","author":[{"given":"Zhao-Bo","family":"Luo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/039xnh269","id-type":"ROR","asserted-by":"publisher"}],"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University","place":["Yanji, 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