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One such feature is the N-terminal formylation of proteins encoded by mitochondrial DNA that undergo translation by mitochondrial ribosomes. N-formylated proteins are also released by bacteria and trigger activation of immune cells, such as neutrophils. Growing evidence indicates that circulating levels of mitochondrial formyl proteins are elevated in the serum of patients with excessive inflammatory responses. However, the mechanisms by which they are released into circulation are not known. In this study, we have identified vascular endothelial cells as a source of Pink1-dependent release of mitochondrial formyl proteins in response to inflammatory mediators. Mechanistically, the mitophagy mediator Pink1 is stabilized by inflammatory activation of endothelial cells, promoting mitophagy and mitochondrial formyl peptide release both in mice and primary human endothelial cells. Using nanoparticle delivery of\n                    <jats:italic>Pink1<\/jats:italic>\n                    -targeting sgRNA in mice expressing endothelial-specific Cas9, we developed a mouse model in which\n                    <jats:italic>Pink1<\/jats:italic>\n                    is specifically depleted in the endothelium. Deletion of endothelial\n                    <jats:italic>Pink1<\/jats:italic>\n                    decreased circulating formyl peptide levels, lowered lung neutrophil infiltration, and reduced mortality in mice. We thus propose that endothelial cells upregulate pro-inflammatory mitophagy in response to inflammation, leading to the release of mitochondrial formyl peptides and detrimental neutrophil recruitment into the lung.\n                  <\/jats:p>","DOI":"10.7554\/elife.82205","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:16:53Z","timestamp":1782893813000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.82205","source":"Crossref","is-referenced-by-count":1,"title":["Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation"],"prefix":"10.7554","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-1934","authenticated-orcid":true,"given":"Priyanka","family":"Gajwani","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047426m28","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Molecular 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