{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:46:12Z","timestamp":1785408372836,"version":"3.56.0"},"reference-count":63,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["PRECISE"],"award-info":[{"award-number":["PRECISE"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSA\/0055\/2013"],"award-info":[{"award-number":["NMRC\/CSA\/0055\/2013"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["NRF-NRFI2018-01"],"award-info":[{"award-number":["NRF-NRFI2018-01"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Ministry of Health -Singapore","doi-asserted-by":"publisher","award":["HLCA20Jan-0022"],"award-info":[{"award-number":["HLCA20Jan-0022"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA144034"],"award-info":[{"award-number":["R01 CA144034"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA182876"],"award-info":[{"award-number":["UM1 CA182876"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,3,24]]},"abstract":"<jats:sec id=\"abs1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the utility of polygenic risk scores (PRSs) in identifying high-risk individuals, different publicly available PRSs for breast (n=85), prostate (n=37), colorectal (n=22), and lung cancers (n=11) were examined in a prospective study of 21,694 Chinese adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We constructed PRS using weights curated in the online PGS Catalog. PRS performance was evaluated by distribution, discrimination, predictive ability, and calibration. Hazard ratios (HR) and corresponding confidence intervals (CI) of the common cancers after 20 years of follow-up were estimated using Cox proportional hazard models for different levels of PRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 495 breast, 308 prostate, 332 female-colorectal, 409 male-colorectal, 181 female-lung, and 381 male-lung incident cancers were identified. The area under receiver operating characteristic curve for the best-performing site-specific PRS were 0.61 (PGS000873, breast), 0.70 (PGS00662, prostate), 0.65 (PGS000055, female-colorectal), 0.60 (PGS000734, male-colorectal), 0.56 (PGS000721, female-lung), and 0.58 (PGS000070, male-lung), respectively. Compared to the middle quintile, individuals in the highest cancer-specific PRS quintile were 64% more likely to develop cancers of the breast, prostate, and colorectal. For lung cancer, the lowest cancer-specific PRS quintile was associated with 28\u201334% decreased risk compared to the middle quintile. In contrast, the HR observed for quintiles 4 (female-lung: 0.95 [0.61\u20131.47]; male-lung: 1.14 [0.82\u20131.57]) and 5 (female-lung: 0.95 [0.61\u20131.47]) were not significantly different from that for the middle quintile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Site-specific PRSs can stratify the risk of developing breast, prostate, and colorectal cancers in this East Asian population. Appropriate correction factors may be required to improve calibration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs5\">\n                    <jats:title>Funding:<\/jats:title>\n                    <jats:p>This work is supported by the National Research Foundation Singapore (NRF-NRFF2017-02), PRECISION Health Research, Singapore (PRECISE) and the Agency for Science, Technology and Research (A*STAR). WP Koh was supported by National Medical Research Council, Singapore (NMRC\/CSA\/0055\/2013). CC Khor was supported by National Research Foundation Singapore (NRF-NRFI2018-01). Rajkumar Dorajoo received a grant from the Agency for Science, Technology and Research Career Development Award (A*STAR CDA - 202D8090), and from Ministry of Health Healthy Longevity Catalyst Award (HLCA20Jan-0022).<\/jats:p>\n                    <jats:p>The Singapore Chinese Health Study was supported by grants from the National Medical Research Council, Singapore (NMRC\/CIRG\/1456\/2016) and the U.S. National Institutes of Health (NIH) (R01 CA144034 and UM1 CA182876).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7554\/elife.82608","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:15:34Z","timestamp":1679897734000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.82608","source":"Crossref","is-referenced-by-count":15,"title":["Polygenic risk scores for the prediction of common cancers in East Asians: A population-based prospective cohort study"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3017-4023","authenticated-orcid":true,"given":"Peh Joo","family":"Ho","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05k8wg936","id-type":"ROR","asserted-by":"publisher"}],"name":"Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)","place":["Singapore, Singapore"]},{"id":[{"id":"https:\/\/ror.org\/01tgyzw49","id-type":"ROR","asserted-by":"publisher"}],"name":"Saw Swee Hock School of Public Health, National University of Singapore and National University Health System","place":["Singapore, Singapore"]},{"id":[{"id":"https:\/\/ror.org\/01tgyzw49","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain BeeHuat","family":"Tan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05k8wg936","id-type":"ROR","asserted-by":"publisher"}],"name":"Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)","place":["Singapore, Singapore"]},{"id":[{"id":"https:\/\/ror.org\/01tgyzw49","id-type":"ROR","asserted-by":"publisher"}],"name":"Saw Swee Hock School of Public Health, National University of Singapore and National University Health System","place":["Singapore, Singapore"]},{"id":[{"id":"https:\/\/ror.org\/02j1m6098","id-type":"ROR","asserted-by":"publisher"}],"name":"Program in Cancer and Stem Cell Biology, Duke-National University of Singapore Medical School","place":["Singapore, Singapore"]},{"id":[{"id":"https:\/\/ror.org\/03bqk3e80","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Medical Oncology, National Cancer Centre Singapore","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn Qingqing","family":"Chong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03bqk3e80","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Medical Oncology, National Cancer Centre Singapore","place":["Singapore, Singapore"]},{"id":[{"id":"https:\/\/ror.org\/02j1m6098","id-type":"ROR","asserted-by":"publisher"}],"name":"Duke-NUS Medical School Singapore","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiea Chuen","family":"Khor","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05k8wg936","id-type":"ROR","asserted-by":"publisher"}],"name":"Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Min","family":"Yuan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03bw34a45","id-type":"ROR","asserted-by":"publisher"}],"name":"UPMC Hillman Cancer Center","place":["Pittsburgh, United States"]},{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health","place":["Pittsburgh, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon-Puay","family":"Koh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01tgyzw49","id-type":"ROR","asserted-by":"publisher"}],"name":"Healthy Longevity Translational Research Programme; 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