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Congenital myopathies are a group of muscle diseases leading to a weak muscle phenotype caused by mutations in a number of genes including\n                    <jats:italic>RYR1<\/jats:italic>\n                    . Patients carrying recessive\n                    <jats:italic>RYR1<\/jats:italic>\n                    mutations usually present from birth and are generally more severely affected, showing preferential involvement of fast twitch muscles as well as extraocular and facial muscles. In order to gain more insight into the pathophysiology of recessive\n                    <jats:italic>RYR1<\/jats:italic>\n                    -congential myopathies, we performed relative and absolute quantitative proteomic analysis of skeletal muscles from wild-type and transgenic mice carrying p.Q1970fsX16 and p.A4329D RyR1 mutations which were identified in a child with a severe congenital myopathy. Our in-depth proteomic analysis shows that recessive\n                    <jats:italic>RYR1<\/jats:italic>\n                    mutations not only decrease the content of RyR1 protein in muscle, but change the expression of 1130, 753, and 967 proteins EDL, soleus and extraocular muscles, respectively. Specifically, recessive\n                    <jats:italic>RYR1<\/jats:italic>\n                    mutations affect the expression level of proteins involved in calcium signaling, extracellular matrix, metabolism and ER protein quality control. This study also reveals the stoichiometry of major proteins involved in excitation contraction coupling and identifies novel potential pharmacological targets to treat RyR1-related congenital myopathies.\n                  <\/jats:p>","DOI":"10.7554\/elife.83618","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T08:00:15Z","timestamp":1677744015000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.83618","source":"Crossref","is-referenced-by-count":28,"title":["Quantitative proteomic analysis of skeletal muscles from wild-type and transgenic mice carrying recessive Ryr1 mutations linked to congenital myopathies"],"prefix":"10.7554","volume":"12","author":[{"given":"Jan","family":"Eckhardt","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04k51q396","id-type":"ROR","asserted-by":"publisher"}],"name":"Departments of Biomedicine and Neurology, Basel University Hospital","place":["Basel, 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