{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:39:24Z","timestamp":1785436764308,"version":"3.56.0"},"reference-count":71,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["ERC-STG-2019"],"award-info":[{"award-number":["ERC-STG-2019"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,5,16]]},"abstract":"<jats:p>\n                    Early-life experiences may promote stereotyped behavioral alterations that are dynamic across development time, but also behavioral responses that are variable among individuals, even when initially exposed to the same stimulus. Here, by utilizing longitudinal monitoring of\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    individuals throughout development we show that behavioral effects of early-life starvation are exposed during early and late developmental stages and buffered during intermediate stages of development. We further found that both dopamine and serotonin shape the discontinuous behavioral responses by opposite and temporally segregated functions across development time. While dopamine buffers behavioral responses during intermediate developmental stages, serotonin promotes behavioral sensitivity to stress during early and late stages. Interestingly, unsupervised analysis of individual biases across development uncovered multiple individuality dimensions that coexist within stressed and unstressed populations and further identified experience-dependent effects on variation within specific individuality dimensions. These results provide insight into the complex temporal regulation of behavioral plasticity across developmental timescales, structuring shared and unique individual responses to early-life experiences.\n                  <\/jats:p>","DOI":"10.7554\/elife.84312","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T08:00:24Z","timestamp":1684310424000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.84312","source":"Crossref","is-referenced-by-count":24,"title":["Early-life experience reorganizes neuromodulatory regulation of stage-specific behavioral responses and individuality dimensions during development"],"prefix":"10.7554","volume":"12","author":[{"given":"Reemy","family":"Ali Nasser","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03qryx823","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Biology, Technion - Israel Institute of Technology","place":["Haifa, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Harel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03qryx823","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Biology, Technion - Israel Institute of Technology","place":["Haifa, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-7938","authenticated-orcid":true,"given":"Shay","family":"Stern","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03qryx823","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Biology, Technion - Israel Institute of Technology","place":["Haifa, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41567-020-01036-8","article-title":"Capturing the continuous complexity of behaviour in Caenorhabditis elegans","volume":"17","author":"Ahamed","year":"2021","journal-title":"Nature Physics"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neuron.2014.09.005","article-title":"Toward a science of computational Ethology","volume":"84","author":"Anderson","year":"2014","journal-title":"Neuron"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/nn1419","article-title":"Vasoactive intestinal polypeptide mediates circadian Rhythmicity and synchrony in mammalian clock neurons","volume":"8","author":"Aton","year":"2005","journal-title":"Nature Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/bies.201100185","article-title":"Beyond the Connectome: how Neuromodulators shape neural circuits","volume":"34","author":"Bargmann","year":"2012","journal-title":"BioEssays"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1534\/genetics.113.150847","article-title":"To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest","volume":"194","author":"Baugh","year":"2013","journal-title":"Genetics"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007584","article-title":"Molecular and sensory basis of a food related two-state behavior in C. elegans","volume":"4","author":"Ben Arous","year":"2009","journal-title":"PLOS ONE"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15361","article-title":"Behavioural individuality in Clonal fish arises despite near-identical rearing conditions","volume":"8","author":"Bierbach","year":"2017","journal-title":"Nature Communications"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41586-021-03284-x","article-title":"A multi-scale brain map derived from whole-brain volumetric Reconstructions","volume":"591","author":"Brittin","year":"2021","journal-title":"Nature"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/s41567-018-0093-0","article-title":"Ethology as a physical science","volume":"14","author":"Brown","year":"2018","journal-title":"Nature Physics"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"6700","DOI":"10.1073\/pnas.1500804112","article-title":"Neuronal control of locomotor handedness in Drosophila","volume":"112","author":"Buchanan","year":"2015","journal-title":"PNAS"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1126\/science.1213491","article-title":"Fitness trade-offs and environmentally induced mutation buffering in Isogenic C. elegans","volume":"335","author":"Casanueva","year":"2012","journal-title":"Science"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/0012-1606(75)90109-8","article-title":"The Dauerlarva, a post-embryonic developmental variant of the Nematode Caenorhabditis elegans","volume":"46","author":"Cassada","year":"1975","journal-title":"Developmental Biology"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57093","article-title":"Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans","volume":"9","author":"Cermak","year":"2020","journal-title":"eLife"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/nn1316","article-title":"Mechanism of Extrasynaptic dopamine signaling in Caenorhabditis elegans","volume":"7","author":"Chase","year":"2004","journal-title":"Nature Neuroscience"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1101\/2021.12.24.474127","article-title":"Neural correlates of individual odor preference in Drosophila","volume-title":"bioRxiv","author":"Churgin","year":"2021"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0022-5193(82)90336-8","article-title":"Adaptive \"coin-flipping\": a decision-Theoretic examination of natural selection for random individual variation","volume":"94","author":"Cooper","year":"1982","journal-title":"Journal of Theoretical Biology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nrg3949","article-title":"Pervasive robustness in biological systems","volume":"16","author":"F\u00e9lix","year":"2015","journal-title":"Nature Reviews. Genetics"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.cell.2013.08.001","article-title":"Serotonin and the neuropeptide PDF initiate and extend opposing behavioral States in C. elegans","volume":"154","author":"Flavell","year":"2013","journal-title":"Cell"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1126\/science.1235294","article-title":"Emergence of individuality in genetically identical mice","volume":"340","author":"Freund","year":"2013","journal-title":"Science"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/s0896-6273(02)01093-0","article-title":"Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase","volume":"36","author":"Fujiwara","year":"2002","journal-title":"Neuron"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/genetics\/101.2.211","article-title":"Dominant suppressors of a muscle mutant define an essential Gene of Caenorhabditis elegans","volume":"101","author":"Greenwald","year":"1982","journal-title":"Genetics"},{"key":"bib22","article-title":"Elegansindividuality","volume-title":"Software Heritage","author":"Harel","year":"2023","unstructured":"Harel Y. 2023. Elegansindividuality. Software Heritage. swh:1:rev:ae42109b6c299e82bfed888c614aaa072775d122. https:\/\/archive.softwareheritage.org\/swh:1:dir:07c08b5e8a19748c33614f54cd7c288fa4d6ed9f;origin=https:\/\/github.com\/yha\/ElegansIndividuality;visit=swh:1:snp:64b03f26e6ee79405dee87df3df827d202b3249b;anchor=swh:1:rev:ae42109b6c299e82bfed888c614aaa072775d122."},{"key":"bib23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev.ne.14.030191.000351","article-title":"Modulation of neural networks for behavior","volume":"14","author":"Harris-Warrick","year":"1991","journal-title":"Annual Review of Neuroscience"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"R8","DOI":"10.1016\/j.cub.2017.11.058","article-title":"Stochasticity, individuality and behavior","volume":"28","author":"Honegger","year":"2018","journal-title":"Current Biology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"23292","DOI":"10.1073\/pnas.1901623116","article-title":"Idiosyncratic neural coding and neuromodulation of olfactory individuality in Drosophila","volume":"117","author":"Honegger","year":"2020","journal-title":"PNAS"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/s0166-2236(97)01219-8","article-title":"Visual Imprinting and the neural mechanisms of recognition memory","volume":"21","author":"Horn","year":"1998","journal-title":"Trends in Neurosciences"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1146\/annurev.es.06.110175.000311","article-title":"Ecological significance of Imprinting and early learning","volume":"6","author":"Immelmann","year":"1975","journal-title":"Annual Review of Ecology and Systematics"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.cell.2016.01.007","article-title":"Distinct circuits for the formation and retrieval of an imprinted olfactory memory","volume":"164","author":"Jin","year":"2016","journal-title":"Cell"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0047-6374(84)90150-7","article-title":"Arresting development arrests aging in the Nematode Caenorhabditis elegans","volume":"28","author":"Johnson","year":"1984","journal-title":"Mechanisms of Ageing and Development"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"19834","DOI":"10.1073\/pnas.1211988109","article-title":"Phototactic personality in fruit flies and its suppression by serotonin and white","volume":"109","author":"Kain","year":"2012","journal-title":"PNAS"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1101\/sqb.2014.79.024984","article-title":"Internal States and behavioral decision-making: toward an integration of emotion and cognition","author":"Kennedy","year":"2014","unstructured":"Kennedy A, Asahina K, Hoopfer E, Inagaki H, Jung Y, Lee H, Remedios R, Anderson DJ. 2014. Internal States and behavioral decision-making: toward an integration of emotion and cognition. Cold Spring Harbor Symposia on Quantitative Biology."},{"key":"bib32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/dev.420070109","article-title":"The development and behavioral characteristics of the startle response in the zebra fish","volume":"7","author":"Kimmel","year":"1974","journal-title":"Developmental Psychobiology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.bbr.2011.07.037","article-title":"Early-life stress mediated modulation of adult Neurogenesis and behavior","volume":"227","author":"Korosi","year":"2012","journal-title":"Behavioural Brain Research"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1126\/science.aaw7182","article-title":"A neurodevelopmental origin of behavioral individuality in the Drosophila visual system","volume":"367","author":"Linneweber","year":"2020","journal-title":"Science"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"5819","DOI":"10.1242\/dev.126.24.5819","article-title":"Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a Tgfbeta family signaling pathway and a Hox Gene","volume":"126","author":"Lints","year":"1999","journal-title":"Development"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/BF01905355","article-title":"Der Kumpan in der Umwelt des Vogels: der Artgenosse ALS Ausl\u00f6sendes moment Sozialer Verhaltungsweisen","volume":"83","author":"Lorenz","year":"1935","journal-title":"Journal of Ornithology"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.777873","article-title":"Neuromodulation and individuality","volume":"15","author":"Maloney","year":"2021","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuron.2012.09.010","article-title":"Neuromodulation of neuronal circuits: back to the future","volume":"76","author":"Marder","year":"2012","journal-title":"Neuron"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2022.102610","article-title":"New insights from small rhythmic circuits","volume":"76","author":"Marder","year":"2022","journal-title":"Current Opinion in Neurobiology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.neuron.2011.12.032","article-title":"Dopaminergic modulation of Sucrose acceptance behavior in Drosophila","volume":"73","author":"Marella","year":"2012","journal-title":"Neuron"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/dgd.12028","article-title":"Neural basis of Imprinting behavior in chicks","volume":"55","author":"Nakamori","year":"2013","journal-title":"Development, Growth & Differentiation"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.1073\/pnas.91.10.4288","article-title":"Evidence for a peripheral olfactory memory in imprinted salmon","volume":"91","author":"Nevitt","year":"1994","journal-title":"PNAS"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.conb.2012.01.003","article-title":"Neuropeptide modulation of microcircuits","volume":"22","author":"Nusbaum","year":"2012","journal-title":"Current Opinion in Neurobiology"},{"key":"bib44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038649","article-title":"Dopamine signaling is essential for precise rates of locomotion by C. elegans","volume":"7","author":"Omura","year":"2012","journal-title":"PLOS ONE"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.neuron.2016.06.016","article-title":"Neuromodulatory regulation of behavioral individuality in Zebrafish","volume":"91","author":"Pantoja","year":"2016","journal-title":"Neuron"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/074873098129000066","article-title":"Isolation and Chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster","volume":"13","author":"Park","year":"1998","journal-title":"Journal of Biological Rhythms"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"16318","DOI":"10.1073\/pnas.1206834109","article-title":"Altered fear learning across development in both mouse and human","volume":"109","author":"Pattwell","year":"2012","journal-title":"PNAS"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1016\/j.cub.2019.07.045","article-title":"Environmental programming of adult foraging behavior in C. elegans","volume":"29","author":"Pradhan","year":"2019","journal-title":"Current Biology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"9828","DOI":"10.1523\/JNEUROSCI.2328-08.2008","article-title":"Developmental regulation of Neuromodulator function in the Stomatogastric ganglion of the lobster, Homarus americanus","volume":"28","author":"Rehm","year":"2008","journal-title":"The Journal of Neuroscience"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1126\/science.1114209","article-title":"An interneuronal chemoreceptor required for olfactory imprinting in C. elegans","volume":"309","author":"Remy","year":"2005","journal-title":"Science"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/sj.emboj.7600057","article-title":"Dopamine modulates the plasticity of Mechanosensory responses in Caenorhabditis elegans","volume":"23","author":"Sanyal","year":"2004","journal-title":"The EMBO Journal"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/S0893-133X(01)00240-8","article-title":"Serotonin-dopamine interactions in the control of conditioned reinforcement and motor behavior","volume":"25","author":"Sasaki-Adams","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/s0896-6273(00)81199-x","article-title":"C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway","volume":"26","author":"Sawin","year":"2000","journal-title":"Neuron"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/dev.20538","article-title":"Personality variation in a Clonal insect: the Pea Aphid, Acyrthosiphon pisum","volume":"53","author":"Schuett","year":"2011","journal-title":"Developmental Psychobiology"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004322","article-title":"Changes in postural syntax characterize sensory modulation and natural variation of C. elegans locomotion","volume":"11","author":"Schwarz","year":"2015","journal-title":"PLOS Computational Biology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1038\/nn1326","article-title":"The neural basis of puberty and adolescence","volume":"7","author":"Sisk","year":"2004","journal-title":"Nature Neuroscience"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0003-3472(84)80139-6","article-title":"Drosophila larval foraging behaviour: developmental stages","volume":"32","author":"Sokolowski","year":"1984","journal-title":"Animal Behaviour"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1016\/j.cell.2017.10.041","article-title":"Neuromodulatory control of long-term behavioral patterns and individuality across development","volume":"171","author":"Stern","year":"2017","journal-title":"Cell"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1111\/j.1471-4159.2005.03268.x","article-title":"Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to Invertebrates from Caenorhabditis elegans: dopamine receptors from C. elegans","volume":"94","author":"Sugiura","year":"2005","journal-title":"Journal of Neurochemistry"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/cne.901630207","article-title":"Dopaminergic neurons in the nematode Caenorhabditis elegans","volume":"163","author":"Sulston","year":"1975","journal-title":"The Journal of Comparative Neurology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1046\/j.1471-4159.2003.01896.x","article-title":"Cloning and characterization of a Caenorhabditis elegans D2-like dopamine receptor","volume":"86","author":"Suo","year":"2003","journal-title":"Journal of Neurochemistry"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1038\/emboj.2009.194","article-title":"Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans","volume":"28","author":"Suo","year":"2009","journal-title":"The EMBO Journal"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.neuron.2012.08.035","article-title":"Peptide neuromodulation in invertebrate model systems","volume":"76","author":"Taghert","year":"2012","journal-title":"Neuron"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"10075","DOI":"10.1523\/JNEUROSCI.1443-12.2012","article-title":"Robustness of a rhythmic circuit to Short- and long-term temperature changes","volume":"32","author":"Tang","year":"2012","journal-title":"Journal of Neuroscience"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0083-6729(05)73001-6","article-title":"Hormonal control of insect Ecdysis: endocrine cascades for coordinating behavior with physiology","volume":"73","author":"Truman","year":"2005","journal-title":"Vitamins & Hormones"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/s0012-1606(03)00447-0","article-title":"LIM Homeobox Gene-dependent expression of Biogenic amine receptors in restricted regions of the C. elegans nervous system","volume":"263","author":"Tsalik","year":"2003","journal-title":"Developmental Biology"},{"key":"bib67","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64988","article-title":"The structure of behavioral variation within a genotype","volume":"10","author":"Werkhoven","year":"2021","journal-title":"eLife"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1242\/jcs.s2-79.313.91","article-title":"Memoirs: the function of the corpus Allatum in the growth and reproduction of Rhodnius Prolixus (Hemiptera)","volume":"s2-79","author":"Wigglesworth","year":"1936","journal-title":"Journal of Cell Science"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0163-1047(05)80039-1","article-title":"Neurobiology of associative learning in the neonate: early olfactory learning","volume":"61","author":"Wilson","year":"1994","journal-title":"Behavioral and Neural Biology"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41586-021-03778-8","article-title":"Connectomes across development reveal principles of brain maturation","volume":"596","author":"Witvliet","year":"2021","journal-title":"Nature"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature04216","article-title":"Pathogenic bacteria induce Aversive olfactory learning in Caenorhabditis elegans","volume":"438","author":"Zhang","year":"2005","journal-title":"Nature"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/84312\/elife-84312-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/84312\/elife-84312-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/84312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:11:58Z","timestamp":1697058718000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/84312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":71,"alternative-id":["10.7554\/eLife.84312"],"URL":"https:\/\/doi.org\/10.7554\/elife.84312","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.10.24.513603","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.10.24.513603","asserted-by":"object"}],"is-supplemented-by":[{"id-type":"doi","id":"10.17632\/fgsyppvpnc.1","asserted-by":"subject"},{"id-type":"doi","id":"10.17632\/kxrcmtyfr6.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.84312.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.84312.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.84312.sa0","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e84312"}}