{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:50:52Z","timestamp":1785412252501,"version":"3.56.0"},"reference-count":41,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIAMH002032"],"award-info":[{"award-number":["ZIAMH002032"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F99NS125816"],"award-info":[{"award-number":["F99NS125816"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,6,5]]},"abstract":"<jats:p>Decades of neuroscientific research has sought to understand medial temporal lobe (MTL) involvement in perception. Apparent inconsistencies in the literature have led to competing interpretations of the available evidence; critically, findings from human participants with naturally occurring MTL damage appear to be inconsistent with data from monkeys with surgical lesions. Here, we leverage a \u2018stimulus-computable\u2019 proxy for the primate ventral visual stream (VVS), which enables us to formally evaluate perceptual demands across stimulus sets, experiments, and species. With this modeling framework, we analyze a series of experiments administered to monkeys with surgical, bilateral damage to perirhinal cortex (PRC), an MTL structure implicated in visual object perception. Across experiments, PRC-lesioned subjects showed no impairment on perceptual tasks; this originally led us(Eldridge et al., 2018) to conclude that PRC is not involved in perception. Here, we find that a \u2018VVS-like\u2019 model predicts both PRC-intact and -lesioned choice behaviors, suggesting that a linear readout of the VVS should be sufficient for performance on these tasks. Evaluating these computational results alongside findings from human experiments, we suggest that results from (Eldridge et al., 2018) alone cannot be used as evidence against PRC involvement in perception. These data indicate that experimental findings from human and non-human primates are consistent. As such, what appeared to be discrepancies between species was in fact due to reliance on informal accounts of perceptual processing.<\/jats:p>","DOI":"10.7554\/elife.84357","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T13:06:42Z","timestamp":1686056802000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.84357","source":"Crossref","is-referenced-by-count":2,"title":["Inconsistencies between human and macaque lesion data can be resolved with a stimulus-computable model of the ventral visual stream"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-1651","authenticated-orcid":true,"given":"Tyler","family":"Bonnen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Stanford University","place":["Stanford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4292-6832","authenticated-orcid":true,"given":"Mark AG","family":"Eldridge","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Neuropsychology, National Institute of Mental Health,National Institutes of Health","place":["Bethesda, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1016\/j.neuropsychologia.2007.05.023","article-title":"The human medial temporal lobe processes Online representations of complex objects","volume":"45","author":"Barense","year":"2007","journal-title":"Neuropsychologia"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9436","article-title":"Neural population control via deep image synthesis","volume":"364","author":"Bashivan","year":"2019","journal-title":"Science"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.neuron.2009.02.007","article-title":"Involvement of medial temporal lobe structures in memory and perception","volume":"61","author":"Baxter","year":"2009","journal-title":"Neuron"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1016\/j.neuron.2021.06.018","article-title":"When the ventral visual stream is not enough: A deep learning account of medial temporal lobe involvement in perception","volume":"109","author":"Bonnen","year":"2021","journal-title":"Neuron"},{"key":"bib5","article-title":"Analysis and visualization scripts","volume-title":"Software Heritage","author":"Bonnen","year":"2023","unstructured":"Bonnen T. 2023. 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