{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:30:06Z","timestamp":1791531006314,"version":"4.3.4"},"reference-count":39,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["R1219"],"award-info":[{"award-number":["R1219"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK110361"],"award-info":[{"award-number":["R01DK110361"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute of the United States","doi-asserted-by":"publisher","award":["ZIA BC011798"],"award-info":[{"award-number":["ZIA BC011798"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"William and Ella Owens Medical Research Foundation, and National Cancer Institute","doi-asserted-by":"publisher","award":["R21 CA218968"],"award-info":[{"award-number":["R21 CA218968"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"William and Ella Owens Medical Research Foundation, and National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA237159"],"award-info":[{"award-number":["R01 CA237159"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"CPRIT Research Training","doi-asserted-by":"publisher","award":["RP140105"],"award-info":[{"award-number":["RP140105"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,6,15]]},"abstract":"<jats:p>\n                    The Hippo pathway plays a central role in tissue development and homeostasis. However, the function of Hippo in pancreatic endocrine development remains obscure. Here, we generated novel conditional genetically engineered mouse models to examine the roles of Hippo pathway-mediated YAP1\/TAZ inhibition in the development stages of endocrine specification and differentiation. While YAP1 protein was localized to the nuclei in bipotent progenitor cells, Neurogenin 3 expressing endocrine progenitors completely lost YAP1 expression. Using genetically engineered mouse models, we found that inactivation of YAP1 requires both an intact Hippo pathway and Neurogenin 3 protein. Gene deletion of Lats1 and 2 kinases (\n                    <jats:italic>Lats1&amp;2<\/jats:italic>\n                    ) in endocrine progenitor cells of developing mouse pancreas using\n                    <jats:italic>\n                      Neurog3\n                      <jats:sup>Cre<\/jats:sup>\n                    <\/jats:italic>\n                    blocked endocrine progenitor cell differentiation and specification, resulting in reduced islets size and a disorganized pancreas at birth. Loss of\n                    <jats:italic>Lats1&amp;2<\/jats:italic>\n                    in Neurogenin 3 expressing cells activated YAP1\/TAZ transcriptional activity and recruited macrophages to the developing pancreas. These defects were rescued by deletion of\n                    <jats:italic>Yap1\/Wwtr1<\/jats:italic>\n                    genes, suggesting that tight regulation of YAP1\/TAZ by Hippo signaling is crucial for pancreatic endocrine specification. In contrast, deletion of\n                    <jats:italic>Lats1&amp;2<\/jats:italic>\n                    using \u03b2-cell-specific Ins1\n                    <jats:italic>\n                      <jats:sup>CreER<\/jats:sup>\n                    <\/jats:italic>\n                    resulted in a phenotypically normal pancreas, indicating that\n                    <jats:italic>Lats1&amp;2<\/jats:italic>\n                    are indispensable for differentiation of endocrine progenitors but not for that of \u03b2-cells. Our results demonstrate that loss of YAP1\/TAZ expression in the pancreatic endocrine compartment is not a passive consequence of endocrine specification. Rather, Hippo pathway-mediated inhibition of YAP1\/TAZ in endocrine progenitors is a prerequisite for endocrine specification and differentiation.\n                  <\/jats:p>","DOI":"10.7554\/elife.84532","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T13:15:06Z","timestamp":1718630106000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.84532","source":"Crossref","is-referenced-by-count":11,"title":["Hippo pathway-mediated YAP1\/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-8651","authenticated-orcid":true,"given":"Yifan","family":"Wu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]},{"id":[{"id":"https:\/\/ror.org\/05c1yfj14","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Obstetrics, The Second Xiangya Hospital, Central South University","place":["Changsha, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Kunhua","family":"Qin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]},{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Medicine, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Shreya","family":"Rajhans","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Truong","family":"Vo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3163-4634","authenticated-orcid":true,"given":"Kevin M","family":"Lopez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Michael H","family":"Nipper","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Janice","family":"Deng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Xue","family":"Yin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Logan R","family":"Ramjit","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Zhenqing","family":"Ye","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Population Health Sciences, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Yu","family":"Luan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-2521","authenticated-orcid":true,"given":"H Efsun","family":"Arda","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-7315","authenticated-orcid":true,"given":"Pei","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio","place":["San Antonio, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.devcel.2013.03.016","type":"journal-article","article-title":"Gene regulatory networks governing pancreas development","volume":"25","author":"Arda","year":"2013","journal-title":"Developmental Cell"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000382","type":"journal-article","article-title":"LATS1\/2 suppress NF\u03baB and aberrant EMT initiation to permit pancreatic progenitor differentiation","volume":"17","author":"Braitsch","year":"2019","journal-title":"PLOS Biology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/ncb3160","type":"journal-article","article-title":"TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors","volume":"17","author":"Cebola","year":"2015","journal-title":"Nature Cell Biology"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201267119","type":"journal-article","article-title":"Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development","volume":"119","author":"Duvall","year":"2022","journal-title":"PNAS"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","type":"journal-article","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Research"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1053\/j.gastro.2013.02.037","type":"journal-article","article-title":"Hippo signaling regulates differentiation and maintenance in the exocrine pancreas","volume":"144","author":"Gao","year":"2013","journal-title":"Gastroenterology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"5116","DOI":"10.1128\/MCB.01034-12","type":"journal-article","article-title":"Hippo signaling regulates pancreas development through inactivation of Yap","volume":"32","author":"George","year":"2012","journal-title":"Molecular and Cellular Biology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1210\/me.2014-1375","type":"journal-article","article-title":"Exploiting expression of hippo effector, yap, for expansion of functional islet mass","volume":"29","author":"George","year":"2015","journal-title":"Molecular Endocrinology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/dvdy.22544","type":"journal-article","article-title":"Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development","volume":"240","author":"Gouzi","year":"2011","journal-title":"Developmental Dynamics"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","type":"journal-article","article-title":"neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas","volume":"97","author":"Gradwohl","year":"2000","journal-title":"PNAS"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/S2468-1253(17)30002-X","type":"journal-article","article-title":"Pancreaticobiliary maljunction and congenital biliary dilatation","volume":"2","author":"Kamisawa","year":"2017","journal-title":"The Lancet. Gastroenterology & Hepatology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1053\/j.gastro.2012.12.043","type":"journal-article","article-title":"Models of acute and chronic pancreatitis","volume":"144","author":"Lerch","year":"2013","journal-title":"Gastroenterology"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000418","type":"journal-article","article-title":"Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption","volume":"17","author":"Liu","year":"2019","journal-title":"PLOS Biology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/nyas.13448","type":"journal-article","article-title":"Nutrient sensing in pancreatic islets: lessons from congenital hyperinsulinism and monogenic diabetes","volume":"1411","author":"Lu","year":"2018","journal-title":"Annals of the New York Academy of Sciences"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.2337\/db15-1122","type":"journal-article","article-title":"AMPK activation by metformin suppresses abnormal extracellular matrix remodeling in adipose tissue and ameliorates insulin resistance in obesity","volume":"65","author":"Luo","year":"2016","journal-title":"Diabetes"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ydbio.2011.08.006","type":"journal-article","article-title":"Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium","volume":"359","author":"Magenheim","year":"2011","journal-title":"Developmental Biology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41586-018-0762-2","type":"journal-article","article-title":"Mechanosignalling via integrins directs fate decisions of pancreatic progenitors","volume":"564","author":"Mamidi","year":"2018","journal-title":"Nature"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.2337\/db14-1412","type":"journal-article","article-title":"The basic helix-loop-helix transcription factor NEUROG3 is required for development of the human endocrine pancreas","volume":"64","author":"McGrath","year":"2015","journal-title":"Diabetes"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9357","type":"journal-article","article-title":"MAP4K family kinases act in parallel to MST1\/2 to activate LATS1\/2 in the Hippo pathway","volume":"6","author":"Meng","year":"2015","journal-title":"Nature Communications"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.3390\/cells13020186","type":"journal-article","article-title":"TGF\u03b2 and hippo signaling pathways coordinate to promote acinar to ductal metaplasia in human pancreas","volume":"13","author":"Nipper","year":"2024","journal-title":"Cells"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","type":"journal-article","article-title":"The hippo signaling pathway in development and cancer","volume":"19","author":"Pan","year":"2010","journal-title":"Developmental Cell"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.stem.2016.08.009","type":"journal-article","article-title":"Induction of expandable tissue-specific stem\/progenitor cells through transient expression of YAP\/TAZ","volume":"19","author":"Panciera","year":"2016","journal-title":"Cell Stem Cell"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1097\/MOG.0000000000000197","type":"journal-article","article-title":"Paediatric pancreatitis","volume":"31","author":"Pohl","year":"2015","journal-title":"Current Opinion in Gastroenterology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1007\/s00125-017-4542-6","type":"journal-article","article-title":"SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice","volume":"61","author":"Qin","year":"2018","journal-title":"Diabetologia"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09404-6","type":"journal-article","article-title":"YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing \u03b2 cells","volume":"10","author":"Rosado-Olivieri","year":"2019","journal-title":"Nature Communications"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.4161\/isl.1.3.9877","type":"journal-article","article-title":"Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration","volume":"1","author":"Rukstalis","year":"2009","journal-title":"Islets"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","type":"journal-article","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nature Methods"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101313","type":"journal-article","article-title":"Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network","volume":"53","author":"Schreiber","year":"2021","journal-title":"Molecular Metabolism"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1073\/pnas.0609217104","type":"journal-article","article-title":"SOX9 is required for maintenance of the pancreatic progenitor cell pool","volume":"104","author":"Seymour","year":"2007","journal-title":"PNAS"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.cell.2018.12.003","type":"journal-article","article-title":"A peninsular structure coordinates asynchronous differentiation with morphogenesis to generate pancreatic islets","volume":"176","author":"Sharon","year":"2019","journal-title":"Cell"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1242\/dev.078634","type":"journal-article","article-title":"A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation","volume":"139","author":"Shih","year":"2012","journal-title":"Development"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/dvg.20672","type":"journal-article","article-title":"Brain expression of Cre recombinase driven by pancreas-specific promoters","volume":"48","author":"Song","year":"2010","journal-title":"Genesis"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"44927","DOI":"10.18632\/oncotarget.10342","type":"journal-article","article-title":"\u03b2-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response","volume":"7","author":"Trinder","year":"2016","journal-title":"Oncotarget"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ydbio.2009.12.009","type":"journal-article","article-title":"Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas","volume":"339","author":"Wang","year":"2010","journal-title":"Developmental Biology"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.663906","type":"journal-article","article-title":"Hippo signaling pathway in pancreas development","volume":"9","author":"Wu","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"36776","DOI":"10.1074\/jbc.M110.168039","type":"journal-article","article-title":"SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice","volume":"285","author":"Xiao","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.02.11","type":"journal-article","article-title":"Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment","volume":"8","author":"Yang","year":"2020","journal-title":"Annals of Translational Medicine"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cell.2015.10.044","type":"journal-article","article-title":"Hippo pathway in organ size control, tissue homeostasis, and cancer","volume":"163","author":"Yu","year":"2015","journal-title":"Cell"},{"key":"dataset1","type":"dataset","article-title":"Hippo pathway-mediated YAP1\/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation","volume-title":"NCBI Gene Expression Omnibus","author":"Yifan","year":"2024","unstructured":"Yifan W, Kunhua Q, Yi X, Shreya R, Kevin L, Jun L, Michael N, Janice D, Xue Y, Logan R, Zhengqing Y, Yu L, Arda HE, Wang P. 2024. Hippo pathway-mediated YAP1\/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation. NCBI Gene Expression Omnibus. http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE262400. GSE262400."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/84532\/elife-84532-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/84532\/elife-84532-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/84532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:17:54Z","timestamp":1787566674000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/84532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":39,"alternative-id":["10.7554\/eLife.84532"],"URL":"https:\/\/doi.org\/10.7554\/elife.84532","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.31.494216","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.05.31.494216","asserted-by":"object"}],"is-supplemented-by":[{"id-type":"accession","id":"GSE262400","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.84532.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.84532.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.84532.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e84532"}}