{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T06:03:54Z","timestamp":1794377034071,"version":"4.9.0"},"reference-count":57,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P20GM103451"],"award-info":[{"award-number":["P20GM103451"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1R01AI097202"],"award-info":[{"award-number":["1R01AI097202"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P50 GM085273"],"award-info":[{"award-number":["P50 GM085273"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["5P20GM103452"],"award-info":[{"award-number":["5P20GM103452"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P20GM121176"],"award-info":[{"award-number":["P20GM121176"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["5 T32 AI007538-19"],"award-info":[{"award-number":["5 T32 AI007538-19"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007179","name":"University of New Mexico","doi-asserted-by":"crossref","award":["School of Medicine"],"award-info":[{"award-number":["School of Medicine"]}],"id":[{"id":"10.13039\/100007179","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007179","name":"University of New Mexico","doi-asserted-by":"crossref","award":["DARPA\/AFRL FA8650-18-C-6898"],"award-info":[{"award-number":["DARPA\/AFRL FA8650-18-C-6898"]}],"id":[{"id":"10.13039\/100007179","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007179","name":"University of New Mexico","doi-asserted-by":"crossref","award":["NCI P30CA118100"],"award-info":[{"award-number":["NCI P30CA118100"]}],"id":[{"id":"10.13039\/100007179","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,10,22]]},"abstract":"<jats:p>\n                    T cells are required to clear infection, and T cell motion plays a role in how quickly a T cell finds its target, from initial naive T cell activation by a dendritic cell to interaction with target cells in infected tissue. To better understand how different tissue environments affect T cell motility, we compared multiple features of T cell motion including speed, persistence, turning angle, directionality, and confinement of T cells moving in multiple murine tissues using microscopy. We quantitatively analyzed naive T cell motility within the lymph node and compared motility parameters with activated CD8 T cells moving within the villi of small intestine and lung under different activation conditions. Our motility analysis found that while the speeds and the overall displacement of T cells vary within all tissues analyzed, T cells in all tissues tended to persist at the same speed. Interestingly, we found that T cells in the lung show a marked population of T cells turning at close to 180\n                    <jats:sup>o<\/jats:sup>\n                    , while T cells in lymph nodes and villi do not exhibit this \u201creversing\u201d movement. T cells in the lung also showed significantly decreased meandering ratios and increased confinement compared to T cells in lymph nodes and villi. These differences in motility patterns led to a decrease in the total volume scanned by T cells in lung compared to T cells in lymph node and villi. These results suggest that the tissue environment in which T cells move can impact the type of motility and ultimately, the efficiency of T cell search for target cells within specialized tissues such as the lung.\n                  <\/jats:p>","DOI":"10.7554\/elife.84916","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:15:07Z","timestamp":1698045307000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.84916","source":"Crossref","is-referenced-by-count":16,"title":["Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-5284","authenticated-orcid":true,"given":"David J","family":"Torres","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01e94xy17","id-type":"ROR","asserted-by":"publisher"}],"name":"Northern New Mexico College","place":["Espa\u00f1ola, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Mrass","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05fs6jp91","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine","place":["Albuquerque, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janie","family":"Byrum","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05fs6jp91","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine","place":["Albuquerque, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arrick","family":"Gonzales","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01e94xy17","id-type":"ROR","asserted-by":"publisher"}],"name":"Northern New Mexico College","place":["Espa\u00f1ola, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick N","family":"Martinez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01e94xy17","id-type":"ROR","asserted-by":"publisher"}],"name":"Northern New Mexico College","place":["Espa\u00f1ola, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Juarez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01e94xy17","id-type":"ROR","asserted-by":"publisher"}],"name":"Northern New Mexico College","place":["Espa\u00f1ola, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Thompson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Immunology, University of Minnesota Medical School","place":["Minneapolis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaiva","family":"Vezys","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/017zqws13","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Immunology, University of Minnesota Medical School","place":["Minneapolis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie E","family":"Moses","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05fs6jp91","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Computer Science, University of New Mexico","place":["Albuquerque, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0069-8106","authenticated-orcid":true,"given":"Judy L","family":"Cannon","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05fs6jp91","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine","place":["Albuquerque, United States"]},{"id":[{"id":"https:\/\/ror.org\/05fs6jp91","id-type":"ROR","asserted-by":"publisher"}],"name":"Autophagy, Inflammation, and Metabolism Center of Biomedical Research Excellence, University of New Mexico School of Medicine","place":["Albuquerque, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41577-020-00470-2","article-title":"Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19","volume":"21","author":"Alon","year":"2021","journal-title":"Nature Reviews. Immunology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"5285","DOI":"10.4049\/jimmunol.1500853","article-title":"Subtle CXCR3-dependent chemotaxis of CTLs within infected tissue allows efficient target localization","volume":"195","author":"Ariotti","year":"2015","journal-title":"Journal of Immunology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1084\/jem.20062079","article-title":"CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner","volume":"204","author":"Asperti-Boursin","year":"2007","journal-title":"The Journal of Experimental Medicine"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.immuni.2006.10.011","article-title":"Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes","volume":"25","author":"Baj\u00e9noff","year":"2006","journal-title":"Immunity"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004058","article-title":"Heterogeneous CD8+ T cell migration in the lymph node in the absence of inflammation revealed by quantitative migration analysis","volume":"11","author":"Banigan","year":"2015","journal-title":"PLOS Computational Biology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature08478","article-title":"Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions","volume":"462","author":"Bartholom\u00e4us","year":"2009","journal-title":"Nature"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1084\/jem.20061278","article-title":"Lymph node topology dictates T cell migration behavior","volume":"204","author":"Beltman","year":"2007","journal-title":"The Journal of Experimental Medicine"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1103\/RevModPhys.83.81","article-title":"Intermittent search strategies","volume":"83","author":"B\u00e9nichou","year":"2011","journal-title":"Reviews of Modern Physics"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41590-017-0029-3","article-title":"Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory","volume":"19","author":"Beura","year":"2018","journal-title":"Nature Immunology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1126\/science.1070945","article-title":"Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy","volume":"296","author":"Bousso","year":"2002","journal-title":"Science"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078940","article-title":"PKC\u03b8 Regulates T cell motility via ezrin-radixin-moesin localization to the uropod","volume":"8","author":"Cannon","year":"2013","journal-title":"PLOS ONE"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.immuni.2021.03.025","article-title":"Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses","volume":"54","author":"Devi","year":"2021","journal-title":"Immunity"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jtbi.2011.11.001","article-title":"T-cell movement on the reticular network","volume":"295","author":"Donovan","year":"2012","journal-title":"Journal of Theoretical Biology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/imr.12746","article-title":"Chemokines and other mediators in the development and functional organization of lymph nodes","volume":"289","author":"Eckert","year":"2019","journal-title":"Immunological Reviews"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"3376","DOI":"10.1002\/eji.200838628","article-title":"CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality","volume":"38","author":"Fadel","year":"2008","journal-title":"European Journal of Immunology"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01501","article-title":"CD4+ T Cell interstitial migration controlled by fibronectin in the inflamed skin","volume":"11","author":"Fernandes","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nri2297","article-title":"CCR7 and its ligands: balancing immunity and tolerance","volume":"8","author":"F\u00f6rster","year":"2008","journal-title":"Nature Reviews. Immunology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/s41577-021-00507-0","article-title":"The spatio-temporal control of effector T cell migration","volume":"21","author":"Fowell","year":"2021","journal-title":"Nature Reviews. Immunology"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004818","article-title":"Persistence and adaptation in immunity: t cells balance the extent and thoroughness of search","volume":"12","author":"Fricke","year":"2016","journal-title":"PLOS Computational Biology"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/acb18c","article-title":"Correlation between speed and turning naturally arises for sparsely sampled cell movements","volume":"20","author":"Ganusov","year":"2023","journal-title":"Physical Biology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.cell.2014.05.044","article-title":"Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g","volume":"158","author":"G\u00e9rard","year":"2014","journal-title":"Cell"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.cell.2015.03.005","article-title":"Immunosurveillance of the liver by intravascular effector CD8(+) T cells","volume":"161","author":"Guidotti","year":"2015","journal-title":"Cell"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.immuni.2016.01.010","article-title":"In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity","volume":"44","author":"Halle","year":"2016","journal-title":"Immunity"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nature11098","article-title":"Generalized L\u00e9vy walks and the role of chemokines in migration of effector CD8+ T cells","volume":"486","author":"Harris","year":"2012","journal-title":"Nature"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53933","article-title":"Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo","volume":"9","author":"Jerison","year":"2020","journal-title":"eLife"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1084\/jem.20040254","article-title":"Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes","volume":"200","author":"Katakai","year":"2004","journal-title":"The Journal of Experimental Medicine"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.4049\/jimmunol.1300739","article-title":"Dendritic cells regulate high-speed interstitial T cell migration in the lymph node via LFA-1\/ICAM-1","volume":"191","author":"Katakai","year":"2013","journal-title":"Journal of Immunology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.4049\/jimmunol.0902022","article-title":"CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection","volume":"183","author":"Kohlmeier","year":"2009","journal-title":"Journal of Immunology"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nri.2015.16","article-title":"T cell migration, search strategies and mechanisms","volume":"16","author":"Krummel","year":"2016","journal-title":"Nature Reviews. Immunology"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005881","article-title":"Live imaging of influenza infection of the trachea reveals dynamic regulation of CD8+ T cell motility by antigen","volume":"12","author":"Lambert Emo","year":"2016","journal-title":"PLOS Pathogens"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126333","article-title":"Bringing statistics up to speed with data in analysis of lymphocyte motility","volume":"10","author":"Letendre","year":"2015","journal-title":"PLOS ONE"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/ni1513","article-title":"Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells","volume":"8","author":"Link","year":"2007","journal-title":"Nature Immunology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.cell.2015.01.056","article-title":"Actin flows mediate a universal coupling between cell speed and cell persistence","volume":"161","author":"Maiuri","year":"2015","journal-title":"Cell"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1128\/JVI.01459-06","article-title":"Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought","volume":"81","author":"Masopust","year":"2007","journal-title":"Journal of Virology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1084\/jem.20090858","article-title":"Dynamic T cell migration program provides resident memory within intestinal epithelium","volume":"207","author":"Masopust","year":"2010","journal-title":"The Journal of Experimental Medicine"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaj1996","article-title":"Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids","volume":"2","author":"McNamara","year":"2017","journal-title":"Science Immunology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1084\/jem.20130091","article-title":"Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4","volume":"210","author":"Mikhak","year":"2013","journal-title":"The Journal of Experimental Medicine"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1073\/pnas.2628040100","article-title":"Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy","volume":"100","author":"Miller","year":"2003","journal-title":"PNAS"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1073\/pnas.0306407101","article-title":"T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node","volume":"101","author":"Miller","year":"2004","journal-title":"PNAS"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01032-2","article-title":"ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs","volume":"8","author":"Mrass","year":"2017","journal-title":"Nature Communications"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1084\/jem.20061780","article-title":"A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress","volume":"204","author":"Nombela-Arrieta","year":"2007","journal-title":"The Journal of Experimental Medicine"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.4049\/jimmunol.178.5.2973","article-title":"CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node","volume":"178","author":"Okada","year":"2007","journal-title":"Journal of Immunology"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003054","article-title":"The initial draining lymph node primes the bulk of the CD8 T cell response and influences memory T cell trafficking after a systemic viral infection","volume":"8","author":"Olson","year":"2012","journal-title":"PLOS Pathogens"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1182\/blood-2012-03-416859","article-title":"IL-7-producing stromal cells are critical for lymph node remodeling","volume":"120","author":"Onder","year":"2012","journal-title":"Blood"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/ni.2682","article-title":"Inflammation-induced interstitial migration of effector CD4","volume":"14","author":"Overstreet","year":"2013","journal-title":"Nature Immunology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.immuni.2021.11.002","article-title":"CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection","volume":"55","author":"Ozga","year":"2022","journal-title":"Immunity"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"5917","DOI":"10.1242\/jcs.093732","article-title":"At the leading edge of three-dimensional cell migration","volume":"125","author":"Petrie","year":"2012","journal-title":"Journal of Cell Science"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.4049\/jimmunol.2100842","article-title":"Liver environment-imposed constraints diversify movement strategies of liver-localized CD8 T cells","volume":"208","author":"Rajakaruna","year":"2022","journal-title":"Journal of Immunology"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01571","article-title":"Quantitative Measurement of Na\u00efve T Cell Association With Dendritic Cells, FRCS, and Blood Vessels in Lymph Nodes","volume":"9","author":"Tasnim","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1016\/j.celrep.2019.02.034","article-title":"Interstitial Migration of CD8\u03b1\u03b2 T cells in the small intestine is dynamic and is dictated by environmental cues","volume":"26","author":"Thompson","year":"2019","journal-title":"Cell Reports"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/imm.12972","article-title":"A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens","volume":"155","author":"Tomlin","year":"2018","journal-title":"Immunology"},{"key":"bib52","article-title":"T-cell-analysis-tool","volume-title":"Software Heritage","author":"Torres","year":"2023","unstructured":"Torres DJ. 2023. T-cell-analysis-tool. Software Heritage. swh:1:rev:f67486fc540bce2314b158c1e97bd539421caff6. https:\/\/archive.softwareheritage.org\/swh:1:dir:f8d2b3a2c1cefd24f0992b42fac96aa0664f3c2e;origin=https:\/\/github.com\/davytorres\/T-cell-analysis-tool;visit=swh:1:snp:7101ea56da9bab67795a95906ccb9529e1d05ff4;anchor=swh:1:rev:f67486fc540bce2314b158c1e97bd539421caff6."},{"key":"bib53","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1034\/j.1600-065x.2003.00076.x","article-title":"A stochastic view of lymphocyte motility and trafficking within the lymph node","volume":"195","author":"Wei","year":"2003","journal-title":"Immunological Reviews"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1084\/jem.20181308","article-title":"CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways","volume":"216","author":"Wein","year":"2019","journal-title":"The Journal of Experimental Medicine"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.immuni.2007.09.006","article-title":"Molecular signature of CD8+ T cell exhaustion during chronic viral infection","volume":"27","author":"Wherry","year":"2007","journal-title":"Immunity"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1084\/jem.20061706","article-title":"CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo","volume":"204","author":"Worbs","year":"2007","journal-title":"The Journal of Experimental Medicine"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/s41580-019-0172-9","article-title":"Mechanisms of 3D cell migration","volume":"20","author":"Yamada","year":"2019","journal-title":"Nature Reviews. Molecular Cell Biology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/84916\/elife-84916-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/84916\/elife-84916-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/84916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T10:50:58Z","timestamp":1700823058000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/84916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":57,"alternative-id":["10.7554\/eLife.84916"],"URL":"https:\/\/doi.org\/10.7554\/elife.84916","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.11.17.516891","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.11.17.516891","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.11.17.516891","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.84916.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.84916.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.84916.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e84916"}}