{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:21:36Z","timestamp":1788801696649,"version":"build-2803163510"},"reference-count":87,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972073"],"award-info":[{"award-number":["81972073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taishan Scholars Program of Shandong Province-Young Taishan Scholars","award":["tsqn201909197"],"award-info":[{"award-number":["tsqn201909197"]}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2019YFA0112100"],"award-info":[{"award-number":["2019YFA0112100"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,2,16]]},"abstract":"<jats:p>\n                    Cerebral ischaemia\u2012reperfusion injury (IRI), during which neurons undergo oxygen-glucose deprivation\/reoxygenation (OGD\/R), is a notable pathological process in many neurological diseases. N1-methyladenosine (m\n                    <jats:sup>1<\/jats:sup>\n                    A) is an RNA modification that can affect gene expression and RNA stability. The m\n                    <jats:sup>1<\/jats:sup>\n                    A landscape and potential functions of m\n                    <jats:sup>1<\/jats:sup>\n                    A modification in neurons remain poorly understood. We explored RNA (mRNA, lncRNA, and circRNA) m\n                    <jats:sup>1<\/jats:sup>\n                    A modification in normal and OGD\/R-treated mouse neurons and the effect of m\n                    <jats:sup>1<\/jats:sup>\n                    A on diverse RNAs. We investigated the m\n                    <jats:sup>1<\/jats:sup>\n                    A landscape in primary neurons, identified m\n                    <jats:sup>1<\/jats:sup>\n                    A-modified RNAs, and found that OGD\/R increased the number of m\n                    <jats:sup>1<\/jats:sup>\n                    A RNAs. m\n                    <jats:sup>1<\/jats:sup>\n                    A modification might also affect the regulatory mechanisms of noncoding RNAs, e.g., lncRNA\u2013RNA binding proteins (RBPs) interactions and circRNA translation. We showed that m\n                    <jats:sup>1<\/jats:sup>\n                    A modification mediates the circRNA\/lncRNA\u2012miRNA\u2013mRNA competing endogenous RNA (ceRNA) mechanism and that 3' untranslated region (3\u2019UTR) modification of mRNAs can hinder miRNA\u2013mRNA binding. Three modification patterns were identified, and genes with different patterns had intrinsic mechanisms with potential m\n                    <jats:sup>1<\/jats:sup>\n                    A-regulatory specificity. Systematic analysis of the m\n                    <jats:sup>1<\/jats:sup>\n                    A landscape in normal and OGD\/R neurons lays a critical foundation for understanding RNA modification and provides new perspectives and a theoretical basis for treating and developing drugs for OGD\/R pathology-related diseases.\n                  <\/jats:p>","DOI":"10.7554\/elife.85324","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T09:15:12Z","timestamp":1676538912000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.85324","source":"Crossref","is-referenced-by-count":22,"title":["The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9006","authenticated-orcid":true,"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfu","family":"Yi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02mh8wx89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Bioinformatics, School of Basic Medical Sciences, Tianjin Medical University","place":["Tianjin, 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