{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:41:17Z","timestamp":1793032877601,"version":"4.5.0"},"reference-count":225,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1 DK130640"],"award-info":[{"award-number":["DP1 DK130640"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2009965"],"award-info":[{"award-number":["GNT2009965"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2016530"],"award-info":[{"award-number":["GNT2016530"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["105631"],"award-info":[{"award-number":["105631"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2013158"],"award-info":[{"award-number":["GNT2013158"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["101789"],"award-info":[{"award-number":["101789"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2002375"],"award-info":[{"award-number":["GNT2002375"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,3,15]]},"abstract":"<jats:p>Cardiometabolic diseases encompass a range of interrelated conditions that arise from underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle factors. While obesity, dyslipidaemia, smoking, and insulin resistance are major risk factors for cardiometabolic diseases, individuals still present in the absence of such traditional risk factors, making it difficult to determine those at greatest risk of disease. Thus, it is crucial to elucidate the genetic, environmental, and molecular underpinnings to better understand, diagnose, and treat cardiometabolic diseases. Much of this information can be garnered using systems genetics, which takes population-based approaches to investigate how genetic variance contributes to complex traits. Despite the important advances made by human genome-wide association studies (GWAS) in this space, corroboration of these findings has been hampered by limitations including the inability to control environmental influence, limited access to pertinent metabolic tissues, and often, poor classification of diseases or phenotypes. A complementary approach to human GWAS is the utilisation of model systems such as genetically diverse mouse panels to study natural genetic and phenotypic variation in a controlled environment. Here, we review mouse genetic reference panels and the opportunities they provide for the study of cardiometabolic diseases and related traits. We discuss how the post-GWAS era has prompted a shift in focus from discovery of novel genetic variants to understanding gene function. Finally, we highlight key advantages and challenges of integrating complementary genetic and multi-omics data from human and mouse populations to advance biological discovery.<\/jats:p>","DOI":"10.7554\/elife.86139","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T07:15:45Z","timestamp":1678864545000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.86139","source":"Crossref","is-referenced-by-count":10,"title":["The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-4122","authenticated-orcid":true,"given":"Aaron W","family":"Jurrjens","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rke0285","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Heart and Diabetes Institute","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/02bfwt286","id-type":"ROR","asserted-by":"publisher"}],"name":"Central Clinical School, Monash University","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8026-4759","authenticated-orcid":true,"given":"Marcus M","family":"Seldin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04gyf1771","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Chemistry and Center for Epigenetics and Metabolism, University of California, Irvine","place":["Irvine, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-1259","authenticated-orcid":true,"given":"Corey","family":"Giles","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rke0285","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Heart and Diabetes Institute","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Department of Cardiometabolic Health, University of Melbourne","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01rxfrp27","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University","place":["Bundoora, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-4665","authenticated-orcid":true,"given":"Peter J","family":"Meikle","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rke0285","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Heart and Diabetes Institute","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/02bfwt286","id-type":"ROR","asserted-by":"publisher"}],"name":"Central Clinical School, Monash University","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Department of Cardiometabolic Health, University of Melbourne","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01rxfrp27","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Department of Cardiovascular Research Translation and Implementation, La Trobe University","place":["Bundoora, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-9467","authenticated-orcid":true,"given":"Brian G","family":"Drew","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rke0285","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Heart and Diabetes Institute","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/02bfwt286","id-type":"ROR","asserted-by":"publisher"}],"name":"Central Clinical School, Monash University","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Department of Cardiometabolic Health, University of Melbourne","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-0602","authenticated-orcid":true,"given":"Anna C","family":"Calkin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rke0285","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Heart and Diabetes Institute","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/02bfwt286","id-type":"ROR","asserted-by":"publisher"}],"name":"Central Clinical School, Monash University","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Baker Department of Cardiometabolic Health, University of Melbourne","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.ajhg.2017.10.007","article-title":"Penetrance of polygenic obesity susceptibility loci across the body mass index distribution","volume":"101","author":"Abadi","year":"2017","journal-title":"American Journal of Human Genetics"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00335-016-9658-3","article-title":"Mapping liver fat female-dependent quantitative trait loci in collaborative cross mice","volume":"27","author":"Abu-Toamih Atamni","year":"2016","journal-title":"Mammalian Genome"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-015-0321-x","article-title":"High-fat-diet induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in the collaborative cross mouse genetic reference population","volume":"17","author":"Abu-Toamih Atamni","year":"2016","journal-title":"BMC Genetics"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00335-016-9667-2","article-title":"Glucose tolerance female-specific QTL mapped in collaborative cross mice","volume":"28","author":"Abu-Toamih Atamni","year":"2017","journal-title":"Mammalian Genome"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s00335-019-09816-1","article-title":"Hepatic gene expression variations in response to high-fat diet-induced impaired glucose tolerance using rnaseq analysis in collaborative cross mouse population","volume":"30","author":"Abu-Toamih Atamni","year":"2019","journal-title":"Mammalian Genome"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jhep.2020.04.003","article-title":"Genome-Wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort\u2606","volume":"73","author":"Anstee","year":"2020","journal-title":"Journal of Hepatology"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1101\/2022.04.21.489063","article-title":"Private and Sub-Family Specific Mutations of Founder Haplotypes in the BXD Family Reveal Phenotypic Consequences Relevant to Health and Disease","volume-title":"bioRxiv","author":"Ashbrook","year":"2020"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cels.2020.12.002","article-title":"A platform for experimental precision medicine: the extended bxd mouse family","volume":"12","author":"Ashbrook","year":"2021","journal-title":"Cell Systems"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.96173","volume-title":"Preclinical Animal Modeling in Medicine","author":"Ashbrook","year":"2021"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.tem.2015.10.004","article-title":"GWAS as a driver of gene discovery in cardiometabolic diseases","volume":"26","author":"Atanasovska","year":"2015","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104468","article-title":"Genetic background and sex control the outcome of high-fat diet feeding in mice","volume":"25","author":"Bachmann","year":"2022","journal-title":"IScience"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.cels.2017.01.005","article-title":"The state of systems genetics in 2017","volume":"4","author":"Baliga","year":"2017","journal-title":"Cell Systems"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03621-1","article-title":"Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics","volume":"9","author":"Barbeira","year":"2018","journal-title":"Nature Communications"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12090840","article-title":"Identification of the transcription factor ATF3 as a direct and indirect regulator of the LDLR","volume":"12","author":"Bauer","year":"2022","journal-title":"Metabolites"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221738","article-title":"The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression","volume":"220","author":"Benegiamo","year":"2023","journal-title":"The Journal of Experimental Medicine"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1007\/s00335-005-0002-6","article-title":"Genetics of body weight in the LXS recombinant inbred mouse strains","volume":"16","author":"Bennett","year":"2005","journal-title":"Mammalian Genome"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1101\/gr.099234.109","article-title":"A high-resolution association mapping panel for the dissection of complex traits in mice","volume":"20","author":"Bennett","year":"2010","journal-title":"Genome Research"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005711","article-title":"Genetic architecture of atherosclerosis in mice: a systems genetics analysis of common inbred strains","volume":"11","author":"Bennett","year":"2015","journal-title":"PLOS Genetics"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.100993","article-title":"A genetic screen identifies crat as A regulator of pancreatic beta-cell insulin secretion","volume":"37","author":"Berdous","year":"2020","journal-title":"Molecular Metabolism"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.cell.2022.04.004","article-title":"Atherosclerosis: recent developments","volume":"185","author":"Bj\u00f6rkegren","year":"2022","journal-title":"Cell"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo3191","article-title":"Sex- and age-dependent genetics of longevity in a heterogeneous mouse population","volume":"377","author":"Bou Sleiman","year":"2022","journal-title":"Science"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s10162-020-00762-3","article-title":"The genetics of variation of the wave 1 amplitude of the mouse auditory brainstem response","volume":"21","author":"Boussaty","year":"2020","journal-title":"Journal of the Association for Research in Otolaryngology"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/j.cell.2017.05.038","article-title":"An expanded view of complex traits: from polygenic to omnigenic","volume":"169","author":"Boyle","year":"2017","journal-title":"Cell"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003452","article-title":"Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in norway: a longitudinal population-based cohort (the HUNT study)","volume":"17","author":"Brandkvist","year":"2020","journal-title":"PLOS Medicine"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16041","article-title":"Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival","volume":"8","author":"Buscher","year":"2017","journal-title":"Nature Communications"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00439-017-1856-x","article-title":"Pleiotropy of cardiometabolic syndrome with obesity-related anthropometric traits determined using empirically derived kinships from the busselton health study","volume":"137","author":"Cadby","year":"2018","journal-title":"Human Genetics"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1194\/jlr.RA119000594","article-title":"Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton family heart study","volume":"61","author":"Cadby","year":"2020","journal-title":"Journal of Lipid Research"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30875-7","article-title":"Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease","volume":"13","author":"Cadby","year":"2022","journal-title":"Nature Communications"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003150","article-title":"Systems genetic analysis of osteoblast-lineage cells","volume":"8","author":"Calabrese","year":"2012","journal-title":"PLOS Genetics"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31544-5","article-title":"Sex differences in heart mitochondria regulate diastolic dysfunction","volume":"13","author":"Cao","year":"2022","journal-title":"Nature Communications"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cels.2017.12.006","article-title":"Integration of multi-omics data from mouse diversity panel highlights mitochondrial dysfunction in non-alcoholic fatty liver disease","volume":"6","author":"Chella Krishnan","year":"2018","journal-title":"Cell Systems"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.molmet.2019.09.009","article-title":"Sex-Specific metabolic functions of adipose lipocalin-2","volume":"30","author":"Chella Krishnan","year":"2019","journal-title":"Molecular Metabolism"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jcmgh.2020.09.004","article-title":"Liver pyruvate kinase promotes NAFLD\/NASH in both mice and humans in a sex-specific manner","volume":"11","author":"Chella Krishnan","year":"2021","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1038\/s42255-021-00481-w","article-title":"Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by NDUFV2","volume":"3","author":"Chella Krishnan","year":"2021","journal-title":"Nature Metabolism"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nature06757","article-title":"Variations in DNA elucidate molecular networks that cause disease","volume":"452","author":"Chen","year":"2008","journal-title":"Nature"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.yjmcc.2020.05.006","article-title":"Identifying modifier genes for hypertrophic cardiomyopathy","volume":"144","author":"Chen","year":"2020","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1038\/ng1104-1133","article-title":"The collaborative cross, a community resource for the genetic analysis of complex traits","volume":"36","author":"Churchill","year":"2004","journal-title":"Nature Genetics"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s00335-012-9414-2","article-title":"The diversity outbred mouse population","volume":"23","author":"Churchill","year":"2012","journal-title":"Mammalian Genome"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nrg3575","article-title":"Systems genetics approaches to understand complex traits","volume":"15","author":"Civelek","year":"2014","journal-title":"Nature Reviews. Genetics"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.ajhg.2017.01.027","article-title":"Genetic regulation of adipose gene expression and cardio-metabolic traits","volume":"100","author":"Civelek","year":"2017","journal-title":"American Journal of Human Genetics"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/509282a","article-title":"Policy: NIH to balance sex in cell and animal studies","volume":"509","author":"Clayton","year":"2014","journal-title":"Nature"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1152\/physiolgenomics.00050.2017","article-title":"Systems genetics identifies a co-regulated module of liver microRNAs associated with plasma LDL cholesterol in murine diet-induced dyslipidemia","volume":"49","author":"Coffey","year":"2017","journal-title":"Physiological Genomics"},{"key":"bib46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20750-8","article-title":"An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease","volume":"12","author":"Cohain","year":"2021","journal-title":"Nature Communications"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s00335-002-2187-2","article-title":"Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice","volume":"14","author":"Colinayo","year":"2003","journal-title":"Mammalian Genome"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1534\/genetics.111.132639","article-title":"The genome architecture of the collaborative cross mouse genetic reference population","volume":"190","author":"Collaborative Cross Consortium","year":"2012","journal-title":"Genetics"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"D650","DOI":"10.1093\/nar\/gkw893","article-title":"CeNDR, the Caenorhabditis elegans natural diversity resource","volume":"45","author":"Cook","year":"2017","journal-title":"Nucleic Acids Research"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/s0009-8981(99)00097-2","article-title":"Apolipoprotein E and atherosclerosis: insight from animal and human studies","volume":"286","author":"Davignon","year":"1999","journal-title":"Clinica Chimica Acta; International Journal of Clinical Chemistry"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00335-013-9448-0","article-title":"Genome-Wide association mapping of blood cell traits in mice","volume":"24","author":"Davis","year":"2013","journal-title":"Mammalian Genome"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"7773","DOI":"10.1096\/fj.202000194R","article-title":"Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse collaborative cross mouse model","volume":"34","author":"de Conti","year":"2020","journal-title":"FASEB Journal"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1530-0277.1989.tb00310.x","article-title":"Ls X SS recombinant inbred strains of mice: initial characterization","volume":"13","author":"DeFries","year":"1989","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/ng.2480","article-title":"Large-scale association analysis identifies new risk loci for coronary artery disease","volume":"45","author":"Deloukas","year":"2013","journal-title":"Nature Genetics"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1024-y","article-title":"Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations","volume":"17","author":"Doran","year":"2016","journal-title":"Genome Biology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1093\/cvr\/cvy084","article-title":"A decade of genome-wide association studies for coronary artery disease: the challenges ahead","volume":"114","author":"Erdmann","year":"2018","journal-title":"Cardiovascular Research"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/hep4.1805","article-title":"Genome\u2010Wide association study of NAFLD using electronic health records","volume":"6","author":"Fairfield","year":"2022","journal-title":"Hepatology Communications"},{"key":"bib58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002038","article-title":"Mouse genome-wide association and systems genetics identify ASXL2 as a regulator of bone mineral density and osteoclastogenesis","volume":"7","author":"Farber","year":"2011","journal-title":"PLOS Genetics"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1126\/science.aad6970","article-title":"Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases","volume":"353","author":"Franz\u00e9n","year":"2016","journal-title":"Science"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1534\/genetics.112.140277","article-title":"Increasing association mapping power and resolution in mouse genetic studies through the use of meta-analysis for structured populations","volume":"191","author":"Furlotte","year":"2012","journal-title":"Genetics"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.ajhg.2018.04.002","article-title":"The post-GWAS era: from association to function","volume":"102","author":"Gallagher","year":"2018","journal-title":"American Journal of Human Genetics"},{"key":"bib62","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-021-00335-2","article-title":"Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences","volume":"15","author":"Ganel","year":"2021","journal-title":"Human Genomics"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/tpj.2017.23","article-title":"Genetic background influences susceptibility to chemotherapy-induced hematotoxicity","volume":"18","author":"Gatti","year":"2018","journal-title":"The Pharmacogenomics Journal"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1194\/jlr.R067249","article-title":"Apoe knockout and knockin mice: the history of their contribution to the understanding of atherogenesis","volume":"57","author":"Getz","year":"2016","journal-title":"Journal of Lipid Research"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1007\/s00335-012-9411-5","article-title":"Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits","volume":"23","author":"Ghazalpour","year":"2012","journal-title":"Mammalian Genome"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41588-018-0303-9","article-title":"Trans-ethnic association study of blood pressure determinants in over 750,000 individuals","volume":"51","author":"Giri","year":"2019","journal-title":"Nature Genetics"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/jcp.21127","article-title":"PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes","volume":"212","author":"Gragnoli","year":"2007","journal-title":"Journal of Cellular Physiology"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/jcp.21954","article-title":"PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians","volume":"222","author":"Gragnoli","year":"2010","journal-title":"Journal of Cellular Physiology"},{"key":"bib69","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-12-2","article-title":"Overweight condition and waist circumference and a candidate gene within the 12q24 locus","volume":"12","author":"Gragnoli","year":"2013","journal-title":"Cardiovascular Diabetology"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.cmet.2021.12.018","article-title":"Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction","volume":"34","author":"Green","year":"2022","journal-title":"Cell Metabolism"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"Human genomics. The genotype-tissue expression (gtex) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium","year":"2015","journal-title":"Science"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The gtex consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"GTEx Consortium","year":"2020","journal-title":"Science"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nature Genetics"},{"key":"bib74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000754","article-title":"Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the stockholm atherosclerosis gene expression (stage) study","volume":"5","author":"H\u00e4gg","year":"2009","journal-title":"PLOS Genetics"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41586-022-04965-x","article-title":"The sequences of 150,119 genomes in the UK Biobank","volume":"607","author":"Halldorsson","year":"2022","journal-title":"Nature"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1101\/gr.090241.108","article-title":"Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans","volume":"19","author":"Harrill","year":"2009","journal-title":"Genome Research"},{"key":"bib77","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-016-0007-6","article-title":"Sex and gender equity in research: rationale for the SAGER guidelines and recommended use","volume":"1","author":"Heidari","year":"2016","journal-title":"Research Integrity and Peer Review"},{"key":"bib78","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137474","article-title":"Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology","volume":"5","author":"Herrera","year":"2020","journal-title":"JCI Insight"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/jre.12258","article-title":"Heritability of periodontal bone loss in mice","volume":"50","author":"Hiyari","year":"2015","journal-title":"Journal of Periodontal Research"},{"key":"bib80","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05607","article-title":"The genetic architecture of NAFLD among inbred strains of mice","volume":"4","author":"Hui","year":"2015","journal-title":"eLife"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1002\/hep.30113","article-title":"The genetic architecture of diet-induced hepatic fibrosis in mice","volume":"68","author":"Hui","year":"2018","journal-title":"Hepatology"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ng.2507","article-title":"Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion","volume":"45","author":"Huyghe","year":"2013","journal-title":"Nature Genetics"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.jacc.2018.07.079","article-title":"Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention","volume":"72","author":"Inouye","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/genetics\/151.2.785","article-title":"Multiple-Trait quantitative trait loci analysis using a large mouse sibship","volume":"151","author":"Jackson","year":"1999","journal-title":"Genetics"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.cels.2018.05.016","article-title":"Systems analyses reveal physiological roles and genetic regulators of liver lipid species","volume":"6","author":"Jha","year":"2018","journal-title":"Cell Systems"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.cels.2018.05.009","article-title":"Genetic regulation of plasma lipid species and their association with metabolic phenotypes","volume":"6","author":"Jha","year":"2018","journal-title":"Cell Systems"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1172\/JCI115993","article-title":"Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences","volume":"90","author":"Jiang","year":"1992","journal-title":"The Journal of Clinical Investigation"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cell.2020.08.036","article-title":"A quantitative proteome map of the human body","volume":"183","author":"Jiang","year":"2020","journal-title":"Cell"},{"key":"bib89","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63033","article-title":"Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population","volume":"10","author":"Julkunen","year":"2021","journal-title":"eLife"},{"key":"bib90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004022","article-title":"Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice","volume":"10","author":"Kang","year":"2014","journal-title":"PLOS Genetics"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1534\/g3.119.400194","article-title":"Determinants of QTL mapping power in the realized collaborative cross","volume":"9","author":"Keele","year":"2019","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"bib92","doi-asserted-by":"publisher","DOI":"10.1093\/g3journal\/jkad027","article-title":"Which mouse multiparental population is right for your study? the collaborative cross inbred strains, their F1 hybrids, or the diversity outbred population","volume":"1","author":"Keele","year":"2023","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"bib93","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1534\/genetics.118.300864","article-title":"Genetic drivers of pancreatic islet function","volume":"209","author":"Keller","year":"2018","journal-title":"Genetics"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.1172\/JCI129143","article-title":"Gene loci associated with insulin secretion in islets from non-diabetic mice","volume":"129","author":"Keller","year":"2019","journal-title":"The Journal of Clinical Investigation"},{"key":"bib95","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1161\/CIRCULATIONAHA.116.024152","article-title":"Functional characterization of the GUCY1A3 coronary artery disease risk locus","volume":"136","author":"Kessler","year":"2017","journal-title":"Circulation"},{"key":"bib96","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1093\/eurheartj\/ehab250","article-title":"Accelerometer-derived physical activity and risk of atrial fibrillation","volume":"42","author":"Khurshid","year":"2021","journal-title":"European Heart Journal"},{"key":"bib97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008489","article-title":"Are drug targets with genetic support twice as likely to be Approved? revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval","volume":"15","author":"King","year":"2019","journal-title":"PLOS Genetics"},{"key":"bib98","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s44161-021-00009-1","article-title":"A mechanistic framework for cardiometabolic and coronary artery diseases","volume":"1","author":"Koplev","year":"2022","journal-title":"Nature Cardiovascular Research"},{"key":"bib99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000591","article-title":"Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics","volume":"5","author":"Koutnikova","year":"2009","journal-title":"PLOS Genetics"},{"key":"bib100","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/s41588-020-0705-3","article-title":"Population-Specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease","volume":"52","author":"Koyama","year":"2020","journal-title":"Nature Genetics"},{"key":"bib101","doi-asserted-by":"publisher","DOI":"10.1101\/2022.08.24.505177","article-title":"Genetic Architecture of Heart Mitochondrial Proteome Influencing Cardiac Hypertrophy","volume-title":"bioRxiv","author":"Krishnan","year":"2022"},{"key":"bib102","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-018-0205-7","article-title":"Tissue-Specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease","volume":"9","author":"Kurt","year":"2018","journal-title":"Biology of Sex Differences"},{"key":"bib103","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1194\/jlr.O072629","article-title":"The metabolic syndrome in men study: a resource for studies of metabolic and cardiovascular diseases","volume":"58","author":"Laakso","year":"2017","journal-title":"Journal of Lipid Research"},{"key":"bib104","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005094","article-title":"Genome-wide association study identifies Nox3 as a critical gene for susceptibility to noise-induced hearing loss","volume":"11","author":"Lavinsky","year":"2015","journal-title":"PLOS Genetics"},{"key":"bib105","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1534\/g3.116.032516","article-title":"The genetic architecture of noise-induced hearing loss: evidence for a gene-by-environment interaction","volume":"6","author":"Lavinsky","year":"2016","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"bib106","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.yexmp.2015.01.012","article-title":"A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity","volume":"98","author":"Le\u00f3n-Mimila","year":"2015","journal-title":"Experimental and Molecular Pathology"},{"key":"bib107","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1126\/science.aad9417","article-title":"Rna splicing is a primary link between genetic variation and disease","volume":"352","author":"Li","year":"2016","journal-title":"Science"},{"key":"bib108","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1101\/gr.251983.119","article-title":"Identifying gene function and module connections by the integration of multispecies expression compendia","volume":"29","author":"Li","year":"2019","journal-title":"Genome Research"},{"key":"bib109","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.tig.2020.01.004","article-title":"Mouse systems genetics as a prelude to precision medicine","volume":"36","author":"Li","year":"2020","journal-title":"Trends in Genetics"},{"key":"bib110","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.cmet.2020.02.015","article-title":"Integrating mouse and human genetic data to move beyond GWAS and identify causal genes in cholesterol metabolism","volume":"31","author":"Li","year":"2020","journal-title":"Cell Metabolism"},{"key":"bib111","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-022-00923-w","article-title":"Publisher correction: transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes","volume":"117","author":"Li","year":"2022","journal-title":"Basic Research in Cardiology"},{"key":"bib112","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/j.1474-9726.2011.00702.x","article-title":"Fat maintenance is a predictor of the murine lifespan response to dietary restriction","volume":"10","author":"Liao","year":"2011","journal-title":"Aging Cell"},{"key":"bib113","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.hrthm.2013.10.051","article-title":"Gene expression and genetic variation in human atria","volume":"11","author":"Lin","year":"2014","journal-title":"Heart Rhythm"},{"key":"bib114","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1534\/g3.118.200655","article-title":"Systems genetics approach to biomarker discovery: GPNMB and heart failure in mice and humans","volume":"8","author":"Lin","year":"2018","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"bib115","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1001\/jamacardio.2018.1919","article-title":"A Swedish nationwide adoption study of the heritability of heart failure","volume":"3","author":"Lindgren","year":"2018","journal-title":"JAMA Cardiology"},{"key":"bib116","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/s42255-020-00278-3","article-title":"A large-scale genome\u2013lipid association MAP guides lipid identification","volume":"2","author":"Linke","year":"2020","journal-title":"Nature Metabolism"},{"key":"bib117","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15948-9","article-title":"The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions","volume":"11","author":"Littlejohns","year":"2020","journal-title":"Nature Communications"},{"key":"bib118","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ygeno.2014.12.002","article-title":"Rna-Seq identifies novel myocardial gene expression signatures of heart failure","volume":"105","author":"Liu","year":"2015","journal-title":"Genomics"},{"key":"bib119","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41586-019-1457-z","article-title":"Exome sequencing of finnish isolates enhances rare-variant association power","volume":"572","author":"Locke","year":"2019","journal-title":"Nature"},{"key":"bib120","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/gbb.12029","article-title":"High-Precision genetic mapping of behavioral traits in the diversity outbred mouse population","volume":"12","author":"Logan","year":"2013","journal-title":"Genes, Brain, and Behavior"},{"key":"bib121","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/nrg2468","article-title":"Metabolic syndrome: from epidemiology to systems biology","volume":"9","author":"Lusis","year":"2008","journal-title":"Nature Reviews. Genetics"},{"key":"bib122","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1194\/jlr.R066944","article-title":"The hybrid mouse diversity panel: a resource for systems genetics analyses of metabolic and cardiovascular traits","volume":"57","author":"Lusis","year":"2016","journal-title":"Journal of Lipid Research"},{"key":"bib123","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nature10811","article-title":"The Drosophila melanogaster genetic reference panel","volume":"482","author":"Mackay","year":"2012","journal-title":"Nature"},{"key":"bib124","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1038\/s41588-018-0241-6","article-title":"Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps","volume":"50","author":"Mahajan","year":"2018","journal-title":"Nature Genetics"},{"key":"bib125","doi-asserted-by":"publisher","first-page":"E1124","DOI":"10.1152\/ajpendo.00707.2010","article-title":"Architecture of energy balance traits in emerging lines of the collaborative cross","volume":"300","author":"Mathes","year":"2011","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"bib126","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13716","article-title":"CC002\/unc females are mouse models of exercise-induced paradoxical fat response","volume":"6","author":"McMullan","year":"2018","journal-title":"Physiological Reports"},{"key":"bib127","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1161\/CIRCRESAHA.115.306566","article-title":"Genetics of coronary artery disease","volume":"118","author":"McPherson","year":"2016","journal-title":"Circulation Research"},{"key":"bib128","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1111\/j.1532-5415.1999.tb01291.x","article-title":"Lifelong treatment with oral DHEA sulfate does not preserve immune function, prevent disease, or improve survival in genetically heterogeneous mice","volume":"47","author":"Miller","year":"1999","journal-title":"Journal of the American Geriatrics Society"},{"key":"bib129","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/acel.12194","article-title":"Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction","volume":"13","author":"Miller","year":"2014","journal-title":"Aging Cell"},{"key":"bib130","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140019","article-title":"Canagliflozin extends life span in genetically heterogeneous male but not female mice","volume":"5","author":"Miller","year":"2020","journal-title":"JCI Insight"},{"key":"bib131","doi-asserted-by":"publisher","first-page":"W104","DOI":"10.1093\/nar\/gkab352","article-title":"CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data","volume":"49","author":"Molendijk","year":"2021","journal-title":"Nucleic Acids Research"},{"key":"bib132","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00125-013-2846-8","article-title":"Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding","volume":"56","author":"Montgomery","year":"2013","journal-title":"Diabetologia"},{"key":"bib133","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.molmet.2018.11.012","article-title":"The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle","volume":"21","author":"Moore","year":"2019","journal-title":"Molecular Metabolism"},{"key":"bib134","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111376","article-title":"Strain-specific metabolic responses to long-term caloric restriction in female ILSXISS recombinant inbred mice","volume":"535","author":"Mulvey","year":"2021","journal-title":"Molecular and Cellular Endocrinology"},{"key":"bib135","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02097-z","article-title":"Exploring health in the UK biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures","volume":"19","author":"Mutz","year":"2021","journal-title":"BMC Medicine"},{"key":"bib136","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1073\/pnas.81.3.814","article-title":"Lengths of chromosomal segments conserved since divergence of man and mouse","volume":"81","author":"Nadeau","year":"1984","journal-title":"PNAS"},{"key":"bib137","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41573-018-0009-9","article-title":"The virtuous cycle of human genetics and mouse models in drug discovery","volume":"18","author":"Nadeau","year":"2019","journal-title":"Nature Reviews. Drug Discovery"},{"key":"bib138","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s11357-008-9048-1","article-title":"Design of aging intervention studies: the nia interventions testing program","volume":"30","author":"Nadon","year":"2008","journal-title":"Age"},{"key":"bib139","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1364-z","article-title":"Gwas and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across emerge network","volume":"17","author":"Namjou","year":"2019","journal-title":"BMC Medicine"},{"key":"bib140","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/ng.3314","article-title":"The support of human genetic evidence for Approved drug indications","volume":"47","author":"Nelson","year":"2015","journal-title":"Nature Genetics"},{"key":"bib141","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.cmet.2021.12.013","article-title":"Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance","volume":"34","author":"Nelson","year":"2022","journal-title":"Cell Metabolism"},{"key":"bib142","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.neuron.2018.11.040","article-title":"Harnessing genetic complexity to enhance translatability of alzheimer\u2019s disease mouse models: a path toward precision medicine","volume":"101","author":"Neuner","year":"2019","journal-title":"Neuron"},{"key":"bib143","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00035","article-title":"Identification of pre-symptomatic gene signatures that predict resilience to cognitive decline in the genetically diverse AD-BXD model","volume":"10","author":"Neuner","year":"2019","journal-title":"Frontiers in Genetics"},{"key":"bib144","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 genomes-based genome-wide association meta-analysis of coronary artery disease","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nature Genetics"},{"key":"bib145","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.chom.2019.03.009","article-title":"The collaborative cross: a systems genetics resource for studying host-pathogen interactions","volume":"25","author":"Noll","year":"2019","journal-title":"Cell Host & Microbe"},{"key":"bib146","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1194\/jlr.M071522","article-title":"Genetic and hormonal control of hepatic steatosis in female and male mice","volume":"58","author":"Norheim","year":"2017","journal-title":"Journal of Lipid Research"},{"key":"bib147","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1194\/jlr.M081398","article-title":"Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR","volume":"59","author":"Norheim","year":"2018","journal-title":"Journal of Lipid Research"},{"key":"bib148","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.cmet.2018.12.013","article-title":"Gene-by-sex interactions in mitochondrial functions and cardio-metabolic traits","volume":"29","author":"Norheim","year":"2019","journal-title":"Cell Metabolism"},{"key":"bib149","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20209684","article-title":"Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis","volume":"17","author":"Norheim","year":"2021","journal-title":"Molecular Systems Biology"},{"key":"bib150","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.cell.2012.08.043","article-title":"Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages","volume":"151","author":"Orozco","year":"2012","journal-title":"Cell"},{"key":"bib151","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1093\/hmg\/ddy093","article-title":"Epigenome-wide association in adipose tissue from the METSIM cohort","volume":"27","author":"Orozco","year":"2018","journal-title":"Human Molecular Genetics"},{"key":"bib152","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-5-43","article-title":"Gene networks associated with conditional fear in mice identified using a systems genetics approach","volume":"5","author":"Park","year":"2011","journal-title":"BMC Systems Biology"},{"key":"bib153","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41586-019-0984-y","article-title":"An integrative systems genetic analysis of mammalian lipid metabolism","volume":"567","author":"Parker","year":"2019","journal-title":"Nature"},{"key":"bib154","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.cmet.2012.12.007","article-title":"Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice","volume":"17","author":"Parks","year":"2013","journal-title":"Cell Metabolism"},{"key":"bib155","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.cmet.2015.01.002","article-title":"Genetic architecture of insulin resistance in the mouse","volume":"21","author":"Parks","year":"2015","journal-title":"Cell Metabolism"},{"key":"bib156","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1101\/gr.113886.110","article-title":"Genetic analysis in the collaborative cross breeding population","volume":"21","author":"Philip","year":"2011","journal-title":"Genome Research"},{"key":"bib157","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1089\/nat.2019.0797","article-title":"Hybrid mouse diversity panel identifies genetic architecture associated with the acute antisense oligonucleotide-mediated inflammatory response to a 2\u2019-O-methoxyethyl antisense oligonucleotide","volume":"29","author":"Pirie","year":"2019","journal-title":"Nucleic Acid Therapeutics"},{"key":"bib158","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1038\/s41591-021-01549-6","article-title":"Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps","volume":"27","author":"Polygenic Risk Score Task Force of the International Common Disease Alliance","year":"2021","journal-title":"Nature Medicine"},{"key":"bib159","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1161\/CIRCGENETICS.109.899443","article-title":"Design of the coronary artery disease genome-wide replication and meta-analysis (cardiogram) study: a genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls","volume":"3","author":"Preuss","year":"2010","journal-title":"Circulation. Cardiovascular Genetics"},{"key":"bib160","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/hmg\/ddy327","article-title":"Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of european ancestry","volume":"28","author":"Pulit","year":"2019","journal-title":"Human Molecular Genetics"},{"key":"bib161","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyab068","article-title":"Genetic architecture modulates diet-induced hepatic mRNA and miRNA expression profiles in diversity outbred mice","volume":"218","author":"Que","year":"2021","journal-title":"Genetics"},{"key":"bib162","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1161\/CIRCGENETICS.113.000732","article-title":"Mapping genetic contributions to cardiac pathology induced by beta-adrenergic stimulation in mice","volume":"8","author":"Rau","year":"2015","journal-title":"Circulation. Cardiovascular Genetics"},{"key":"bib163","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cels.2016.10.016","article-title":"Systems genetics approach identifies gene pathways and adamts2 as drivers of isoproterenol-induced cardiac hypertrophy and cardiomyopathy in mice","volume":"4","author":"Rau","year":"2017","journal-title":"Cell Systems"},{"key":"bib164","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1152\/physiolgenomics.00068.2006","article-title":"Murine weight loss exhibits significant genetic variation during dietary restriction","volume":"27","author":"Rikke","year":"2006","journal-title":"Physiological Genomics"},{"key":"bib165","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1038\/s42255-021-00478-5","article-title":"Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases","volume":"3","author":"Ritchie","year":"2021","journal-title":"Nature Metabolism"},{"key":"bib166","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00335-007-9045-1","article-title":"The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics","volume":"18","author":"Roberts","year":"2007","journal-title":"Mammalian Genome"},{"key":"bib167","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/s41588-018-0133-9","article-title":"Multi-Ethnic genome-wide association study for atrial fibrillation","volume":"50","author":"Roselli","year":"2018","journal-title":"Nature Genetics"},{"key":"bib168","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/s42255-021-00449-w","article-title":"Gene-By-Environment modulation of lifespan and weight gain in the murine bxd family","volume":"3","author":"Roy","year":"2021","journal-title":"Nature Metabolism"},{"key":"bib169","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-018-0046-3","article-title":"A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure","volume":"4","author":"Santolini","year":"2018","journal-title":"NPJ Systems Biology and Applications"},{"key":"bib170","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1016\/j.celrep.2017.05.077","article-title":"The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue","volume":"19","author":"Schugar","year":"2017","journal-title":"Cell Reports"},{"key":"bib171","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ng.784","article-title":"Large-Scale association analysis identifies 13 new susceptibility loci for coronary artery disease","volume":"43","author":"Schunkert","year":"2011","journal-title":"Nature Genetics"},{"key":"bib172","doi-asserted-by":"publisher","first-page":"H728","DOI":"10.1152\/ajpheart.00068.2016","article-title":"A systems genetics approach identifies trp53inp2 as A link between cardiomyocyte glucose utilization and hypertrophic response","volume":"312","author":"Seldin","year":"2017","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"bib173","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.cmet.2018.03.015","article-title":"A strategy for discovery of endocrine interactions with application to whole-body metabolism","volume":"27","author":"Seldin","year":"2018","journal-title":"Cell Metabolism"},{"key":"bib174","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/s42255-019-0132-x","article-title":"Systems genetics applications in metabolism research","volume":"1","author":"Seldin","year":"2019","journal-title":"Nature Metabolism"},{"key":"bib175","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1534\/g3.119.400039","article-title":"Whole genome sequencing and progress toward full inbreeding of the mouse collaborative cross population","volume":"9","author":"Shorter","year":"2019","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"bib176","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/ejhg.2010.26","article-title":"Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies","volume":"18","author":"Siontis","year":"2010","journal-title":"European Journal of Human Genetics"},{"key":"bib177","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.neuron.2016.08.013","article-title":"Genetic background limits generalizability of genotype-phenotype relationships","volume":"91","author":"Sittig","year":"2016","journal-title":"Neuron"},{"key":"bib178","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1534\/g3.114.014704","article-title":"High-resolution genetic mapping in the diversity outbred mouse population identifies apobec1 as a candidate gene for atherosclerosis","volume":"4","author":"Smallwood","year":"2014","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"bib179","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s11357-022-00641-0","article-title":"Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice","volume":"45","author":"Snyder","year":"2023","journal-title":"GeroScience"},{"key":"bib180","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3350\/cmh.2016.0109","article-title":"Genetic predisposition in nonalcoholic fatty liver disease","volume":"23","author":"Sookoian","year":"2017","journal-title":"Clinical and Molecular Hepatology"},{"key":"bib181","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky837","article-title":"ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci","volume":"47","author":"Stacey","year":"2019","journal-title":"Nucleic Acids Research"},{"key":"bib182","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.2337\/db08-1607","article-title":"Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 finnish men","volume":"58","author":"Stanc\u00e1kov\u00e1","year":"2009","journal-title":"Diabetes"},{"key":"bib183","doi-asserted-by":"publisher","DOI":"10.1093\/g3journal\/jkab293","article-title":"A systems approach using diversity outbred mice distinguishes the cardiovascular effects and genetics of circulating gdf11 from those of its homolog, myostatin","volume":"11","author":"Starcher","year":"2021","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"bib184","doi-asserted-by":"publisher","first-page":"19135","DOI":"10.1074\/jbc.M117.818351","article-title":"Metabolomic analysis of insulin resistance across different mouse strains and diets","volume":"292","author":"St\u00f6ckli","year":"2017","journal-title":"The Journal of Biological Chemistry"},{"key":"bib185","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007309","article-title":"Population structure in genetic studies: confounding factors and mixed models","volume":"14","author":"Sul","year":"2018","journal-title":"PLOS Genetics"},{"key":"bib186","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003498","article-title":"Polygenic risk scores in cardiovascular risk prediction: a cohort study and modelling analyses","volume":"18","author":"Sun","year":"2021","journal-title":"PLOS Medicine"},{"key":"bib187","doi-asserted-by":"publisher","DOI":"10.1101\/2022.06.17.496443","article-title":"Genetic Regulation of the Human Plasma Proteome in 54,306 UK Biobank Participants","volume-title":"bioRxiv","author":"Sun","year":"2022"},{"key":"bib188","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1534\/genetics.111.132597","article-title":"High-Resolution genetic mapping using the mouse diversity outbred population","volume":"190","author":"Svenson","year":"2012","journal-title":"Genetics"},{"key":"bib189","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.tig.2020.09.007","article-title":"Mouse genetic reference populations: cellular platforms for integrative systems genetics","volume":"37","author":"Swanzey","year":"2021","journal-title":"Trends in Genetics"},{"key":"bib190","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/s41588-021-00885-0","article-title":"Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank","volume":"53","author":"Szustakowski","year":"2021","journal-title":"Nature Genetics"},{"key":"bib191","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/978-1-4939-9581-3_10","article-title":"Networking in biology: the hybrid rat diversity panel","volume":"2018","author":"Tabakoff","year":"2019","journal-title":"Methods in Molecular Biology"},{"key":"bib192","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.cels.2016.02.002","article-title":"Cross-tissue regulatory gene networks in coronary artery disease","volume":"2","author":"Talukdar","year":"2016","journal-title":"Cell Systems"},{"key":"bib193","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1161\/CIRCRESAHA.120.317254","article-title":"Epigenomes of human hearts reveal new genetic variants relevant for cardiac disease and phenotype","volume":"127","author":"Tan","year":"2020","journal-title":"Circulation Research"},{"key":"bib194","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3181\/00379727-143-37380","article-title":"Genetic analysis of resistance to cadmium-induced testicular damage in mice","volume":"143","author":"Taylor","year":"1973","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"bib195","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s003359900998","article-title":"Genotyping new bxd recombinant inbred mouse strains and comparison of bxd and consensus maps","volume":"10","author":"Taylor","year":"1999","journal-title":"Mammalian Genome"},{"key":"bib196","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/ng.782","article-title":"A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease","volume":"43","author":"The Coronary Artery Disease (C4D) Genetics Consortium","year":"2011","journal-title":"Nature Genetics"},{"key":"bib197","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00335-001-4001-Y","article-title":"Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort","volume":"13","author":"Threadgill","year":"2002","journal-title":"Mammalian Genome"},{"key":"bib198","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart disease and stroke statistics-2022 update: a report from the American heart association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"bib199","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1161\/CIRCULATIONAHA.119.045401","article-title":"Transcriptional and cellular diversity of the human heart","volume":"142","author":"Tucker","year":"2020","journal-title":"Circulation"},{"key":"bib200","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1534\/genetics.116.198051","article-title":"Epistatic networks jointly influence phenotypes related to metabolic disease and gene expression in diversity outbred mice","volume":"206","author":"Tyler","year":"2017","journal-title":"Genetics"},{"key":"bib201","doi-asserted-by":"crossref","first-page":"10540","DOI":"10.1016\/S0021-9258(18)82232-3","article-title":"Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia","volume":"268","author":"van den Maagdenberg","year":"1993","journal-title":"The Journal of Biological Chemistry"},{"key":"bib202","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.atherosclerosis.2015.01.018","article-title":"Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the athero-express genomics study","volume":"239","author":"van der Laan","year":"2015","journal-title":"Atherosclerosis"},{"key":"bib203","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/s41586-020-2853-0","article-title":"Exome sequencing and characterization of 49,960 individuals in the UK biobank","volume":"586","author":"Van Hout","year":"2020","journal-title":"Nature"},{"key":"bib204","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1126\/science.1058040","article-title":"The sequence of the human genome","volume":"291","author":"Venter","year":"2001","journal-title":"Science"},{"key":"bib205","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.cmet.2016.11.001","article-title":"Applications and limitations of mouse models for understanding human atherosclerosis","volume":"25","author":"von Scheidt","year":"2017","journal-title":"Cell Metabolism"},{"key":"bib206","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1161\/CIRCULATIONAHA.120.050186","article-title":"Transcription factor MAFF (MAF basic leucine zipper transcription factor F) regulates an atherosclerosis relevant network connecting inflammation and cholesterol metabolism","volume":"143","author":"von Scheidt","year":"2021","journal-title":"Circulation"},{"key":"bib207","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/MOL.0000000000000742","article-title":"Cross-Species data integration to prioritize causal genes in lipid metabolism","volume":"32","author":"Votava","year":"2021","journal-title":"Current Opinion in Lipidology"},{"key":"bib208","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006038","article-title":"Genetic dissection of cardiac remodeling in an isoproterenol-induced heart failure mouse model","volume":"12","author":"Wang","year":"2016","journal-title":"PLOS Genetics"},{"key":"bib209","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00100","article-title":"Isoproterenol-induced cardiac diastolic dysfunction in mice: a systems genetics analysis","volume":"6","author":"Wang","year":"2019","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"bib210","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/nature01262","article-title":"Initial sequencing and comparative analysis of the mouse genome","volume":"420","author":"Waterston","year":"2002","journal-title":"Nature"},{"key":"bib211","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s00335-004-2380-6","article-title":"Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis","volume":"15","author":"Williams","year":"2004","journal-title":"Mammalian Genome"},{"key":"bib212","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/B978-0-12-398323-7.00006-9","article-title":"Genetic and molecular network analysis of behavior","volume":"104","author":"Williams","year":"2012","journal-title":"International Review of Neurobiology"},{"key":"bib213","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0189","article-title":"Systems proteomics of liver mitochondria function","volume":"352","author":"Williams","year":"2016","journal-title":"Science"},{"key":"bib214","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64329","article-title":"Age and diet shape the genetic architecture of body weight in diversity outbred mice","volume":"11","author":"Wright","year":"2022","journal-title":"eLife"},{"key":"bib215","doi-asserted-by":"publisher","DOI":"10.1186\/s12263-022-00714-x","article-title":"Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the collaborative cross","volume":"17","author":"Yam","year":"2022","journal-title":"Genes & Nutrition"},{"key":"bib216","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/nmeth.1359","article-title":"A customized and versatile high-density genotyping array for the mouse","volume":"6","author":"Yang","year":"2009","journal-title":"Nature Methods"},{"key":"bib217","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103099","article-title":"Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet","volume":"24","author":"Yau","year":"2021","journal-title":"IScience"},{"key":"bib218","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29143-5","article-title":"Genome-Wide association studies of metabolites in Finnish men identify disease-relevant loci","volume":"13","author":"Yin","year":"2022","journal-title":"Nature Communications"},{"key":"bib219","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"key":"bib220","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1534\/g3.119.400232","article-title":"Doxorubicin-induced cardiotoxicity in collaborative cross (CC) mice recapitulates individual cardiotoxicity in humans","volume":"9","author":"Zeiss","year":"2019","journal-title":"G3: Genes, Genomes, Genetics"},{"key":"bib221","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Statistical Applications in Genetics and Molecular Biology"},{"key":"bib222","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1090023","article-title":"Western diet augments metabolic and arterial dysfunction in a sex-specific manner in outbred, genetically diverse mice","volume":"9","author":"Zheng","year":"2022","journal-title":"Frontiers in Nutrition"},{"key":"bib223","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.stemcr.2015.05.008","article-title":"The genetic landscape of hematopoietic stem cell frequency in mice","volume":"5","author":"Zhou","year":"2015","journal-title":"Stem Cell Reports"},{"key":"bib224","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.1111\/cas.14651","article-title":"System biology analysis reveals the role of voltage-dependent anion channel in mitochondrial dysfunction during non-alcoholic fatty liver disease progression into hepatocellular carcinoma","volume":"111","author":"Zhu","year":"2020","journal-title":"Cancer Science"},{"key":"bib225","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111597","article-title":"Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes","volume":"201","author":"Zhu","year":"2022","journal-title":"Mechanisms of Ageing and Development"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/86139\/elife-86139-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/86139\/elife-86139-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/86139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:15:18Z","timestamp":1697058918000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/86139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":225,"alternative-id":["10.7554\/eLife.86139"],"URL":"https:\/\/doi.org\/10.7554\/elife.86139","archive":["CLOCKSS"],"relation":{},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e86139"}}