{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:50:36Z","timestamp":1791316236434,"version":"4.3.1"},"reference-count":36,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-108349RB-100"],"award-info":[{"award-number":["PID2019-108349RB-100"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2016-79792R"],"award-info":[{"award-number":["SAF2016-79792R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010438","name":"Francis Crick Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2023,7,16]]},"abstract":"<jats:p>\n                    Evidence implicating p38\u03b3 and p38\u03b4 (p38\u03b3\/p38\u03b4) in inflammation are mainly based on experiments using\n                    <jats:italic>Mapk12\/Mapk13<\/jats:italic>\n                    -deficient (p38\u03b3\/\u03b4KO) mice, which show low levels of TPL2, the kinase upstream of MKK1\u2013ERK1\/2 in myeloid cells. This could obscure p38\u03b3\/p38\u03b4 roles, since TPL2 is essential for regulating inflammation. Here, we generated a\n                    <jats:italic>Mapk12<\/jats:italic>\n                    <jats:sup>D171A\/D171A<\/jats:sup>\n                    \/\n                    <jats:italic>Mapk13<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    (p38\u03b3\/\u03b4KIKO) mouse, expressing kinase-inactive p38\u03b3 and lacking p38\u03b4. This mouse exhibited normal TPL2 levels, making it an excellent tool to elucidate specific p38\u03b3\/p38\u03b4 functions. p38\u03b3\/\u03b4KIKO mice showed a reduced inflammatory response and less susceptibility to lipopolysaccharide (LPS)-induced septic shock and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    infection than wild-type (WT) mice. Gene expression analyses in LPS-activated wild-type and p38\u03b3\/\u03b4KIKO macrophages revealed that p38\u03b3\/p38\u03b4-regulated numerous genes implicated in innate immune response. Additionally, phospho-proteomic analyses and in vitro kinase assays showed that the transcription factor myocyte enhancer factor-2D (MEF2D) was phosphorylated at Ser444 via p38\u03b3\/p38\u03b4. Mutation of MEF2D Ser444 to the non-phosphorylatable residue Ala increased its transcriptional activity and the expression of\n                    <jats:italic>Nos2<\/jats:italic>\n                    and\n                    <jats:italic>Il1b<\/jats:italic>\n                    mRNA. These results suggest that p38\u03b3\/p38\u03b4 govern innate immune responses by regulating MEF2D phosphorylation and transcriptional activity.\n                  <\/jats:p>","DOI":"10.7554\/elife.86200","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T07:40:14Z","timestamp":1689579614000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.86200","source":"Crossref","is-referenced-by-count":11,"title":["p38\u03b3 and p38\u03b4 modulate innate immune response by regulating MEF2D activation"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-7920","authenticated-orcid":true,"given":"Alejandra","family":"Esc\u00f3s","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015w4v032","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda\/CSIC (CNB-CSIC), Campus-UAM","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-0943","authenticated-orcid":true,"given":"Ester","family":"Diaz-Mora","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015w4v032","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda\/CSIC (CNB-CSIC), Campus-UAM","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pattison","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04tnbqb63","id-type":"ROR","asserted-by":"publisher"}],"name":"The Francis Crick Institute","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-7354","authenticated-orcid":true,"given":"Pilar","family":"Fajardo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015w4v032","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda\/CSIC (CNB-CSIC), Campus-UAM","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-3326","authenticated-orcid":true,"given":"Diego","family":"Gonz\u00e1lez-Romero","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015w4v032","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda\/CSIC (CNB-CSIC), Campus-UAM","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Risco","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015w4v032","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda\/CSIC (CNB-CSIC), Campus-UAM","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Mart\u00edn-G\u00f3mez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015w4v032","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda\/CSIC (CNB-CSIC), Campus-UAM","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Bonneil","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00wj6x496","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-8759","authenticated-orcid":true,"given":"Nahum","family":"Sonenberg","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Goodman Cancer Research Center, McGill University","place":["Montreal, Canada"]},{"name":"Department of Biochemistry, McGill University","place":["Montr\u00e9al, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5129-7081","authenticated-orcid":true,"given":"Seyed Mehdi","family":"Jafarnejad","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hswnk62","id-type":"ROR","asserted-by":"publisher"}],"name":"Patrick G. Johnston Centre for Cancer Research, Queen\u2019s University Belfast","place":["Belfast, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-6354","authenticated-orcid":true,"given":"Juan Jos\u00e9","family":"Sanz-Ezquerro","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015w4v032","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular and Cellular Biology, CNB-CSIC","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-9223","authenticated-orcid":true,"given":"Steven C","family":"Ley","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04tnbqb63","id-type":"ROR","asserted-by":"publisher"}],"name":"The Francis Crick Institute","place":["London, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Immunity & Transplantation, University College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9013-5077","authenticated-orcid":true,"given":"Ana","family":"Cuenda","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015w4v032","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda\/CSIC (CNB-CSIC), Campus-UAM","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708485","article-title":"Myeloid cell deficiency of p38\u03b3\/p38\u03b4 protects against candidiasis and regulates antifungal immunity","volume":"10","author":"Alsina-Beauchamp","year":"2018","journal-title":"EMBO Molecular Medicine"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nature Reviews Immunology"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00189","article-title":"B Cell Development and T-Dependent Antibody Response Are Regulated by p38\u03b3 and p38\u03b4","volume":"8","author":"Barrio","year":"2020","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"941","DOI":"10.4049\/jimmunol.2100213","article-title":"TPL-2 Inhibits IFN-\u03b2 Expression via an ERK1\/2-TCF-FOS Axis in TLR4-Stimulated Macrophages","volume":"208","author":"Blair","year":"2022","journal-title":"The Journal of Immunology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"4640","DOI":"10.1523\/JNEUROSCI.2510-12.2014","article-title":"ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage","volume":"34","author":"Chan","year":"2014","journal-title":"The Journal of Neuroscience"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ceb.2009.01.015","article-title":"Targeting protein kinases for the development of anti-inflammatory drugs","volume":"21","author":"Cohen","year":"2009","journal-title":"Current Opinion in Cell Biology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.bbamcr.2007.03.010","article-title":"p38 MAP-Kinases pathway regulation, function and role in human diseases","volume":"1773","author":"Cuenda","year":"2007","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.tibs.2017.02.008","article-title":"p38\u03b3 and p38\u03b4: From Spectators to Key Physiological Players","volume":"42","author":"Cuenda","year":"2017","journal-title":"Trends in Biochemical Sciences"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"6150","DOI":"10.1158\/0008-5472.CAN-14-0870","article-title":"Pro-Oncogenic Role of Alternative p38 Mitogen-Activated Protein Kinases p38\u03b3 and p38\u03b4, Linking Inflammation and Cancer in Colitis-Associated Colon Cancer","volume":"74","author":"del Reino","year":"2014","journal-title":"Cancer Research"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1083033","article-title":"p38\u03b4 controls Mitogen- and Stress-activated Kinase-1 (MSK1) function in response to toll-like receptor activation in macrophages","volume":"11","author":"Diaz-Mora","year":"2023","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/S0092-8674(00)00210-5","article-title":"TNF-\u03b1 Induction by LPS Is Regulated Posttranscriptionally via a Tpl2\/ERK-Dependent Pathway","volume":"103","author":"Dumitru","year":"2000","journal-title":"Cell"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204752119","article-title":"TPL2 kinase expression is regulated by the p38\u03b3\/p38\u03b4-dependent association of aconitase-1 with TPL2 mRNA","volume":"119","author":"Esc\u00f3s","year":"2022","journal-title":"PNAS"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nrd2829","article-title":"Targeting innate immunity protein kinase signalling in inflammation","volume":"8","author":"Gaestel","year":"2009","journal-title":"Nature Reviews Drug Discovery"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/cr.2010.173","article-title":"Regulation and function of TPL-2, an I\u03baB kinase-regulated MAP kinase kinase kinase","volume":"21","author":"Gantke","year":"2011","journal-title":"Cell Research"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"4423","DOI":"10.1074\/jbc.M509471200","article-title":"Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation","volume":"281","author":"Gr\u00e9goire","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1128\/MCB.15.6.2907","article-title":"Regulatory Role of MEF2D in Serum Induction of the c-        jun        Promoter","volume":"15","author":"Han","year":"1995","journal-title":"Molecular and Cellular Biology"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22092.1","article-title":"An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling","volume":"9","author":"Han","year":"2020","journal-title":"F1000Research"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"18534","DOI":"10.1074\/jbc.M001573200","article-title":"Big mitogen-activated kinase regulates multiple members of the MEF2 protein family","volume":"275","author":"Kato","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s12031-014-0466-5","article-title":"CDK5 contributes to neuronal apoptosis via promoting MEF2D phosphorylation in rat model of intracerebral hemorrhage","volume":"56","author":"Ke","year":"2015","journal-title":"Journal of Molecular Neuroscience"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"4231","DOI":"10.1172\/JCI63917","article-title":"Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis","volume":"122","author":"Koliaraki","year":"2012","journal-title":"Journal of Clinical Investigation"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"19472","DOI":"10.1074\/jbc.M414221200","article-title":"BIRB796 Inhibits All p38 MAPK Isoforms in Vitro and in Vivo","volume":"280","author":"Kuma","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1146\/annurev.biochem.76.060605.122847","article-title":"Signaling pathways downstream of pattern-recognition receptors and their cross talk","volume":"76","author":"Lee","year":"2007","journal-title":"Annual Review of Biochemistry"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.2147\/JIR.S307624","article-title":"Regulation of IFN-Is by MEF2D Promotes Inflammatory Homeostasis in Microglia","volume":"14","author":"Lu","year":"2021","journal-title":"Journal of Inflammation Research"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0968-0004(01)02031-X","article-title":"MEF2: a calcium-dependent regulator of cell division, differentiation and death","volume":"27","author":"McKinsey","year":"2002","journal-title":"Trends in Biochemical Sciences"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/978-1-60761-913-0_18","article-title":"Immobilized metal affinity chromatography\/reversed-phase enrichment of phosphopeptides and analysis by CID\/ETD tandem mass spectrometry","volume":"681","author":"Navajas","year":"2011","journal-title":"Methods in Molecular Biology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0161-5890(02)00055-X","article-title":"Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter","volume":"39","author":"Park","year":"2002","journal-title":"Molecular Immunology"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20201859","article-title":"Loss of Mef2D function enhances TLR induced IL-10 production in macrophages","volume":"40","author":"Pattison","year":"2020","journal-title":"Bioscience Reports"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: A hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Research"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"11200","DOI":"10.1073\/pnas.1207290109","article-title":"p38\u03b3 and p38\u03b4 kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1\/2 protein kinase pathway activation","volume":"109","author":"Risco","year":"2012","journal-title":"PNAS"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/sj.emboj.7600578","article-title":"p38\u03b3 regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP","volume":"24","author":"Sabio","year":"2005","journal-title":"The EMBO Journal"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1242\/jcs.066514","article-title":"p38\u03b3 regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock","volume":"123","author":"Sabio","year":"2010","journal-title":"Journal of Cell Science"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Analytical Chemistry"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern Recognition Receptors and Inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"4823","DOI":"10.1523\/JNEUROSCI.1331-05.2005","article-title":"Cyclin-Dependent Kinase 5 Mediates Neurotoxin-Induced Degradation of the Transcription Factor Myocyte Enhancer Factor 2","volume":"25","author":"Tang","year":"2005","journal-title":"The Journal of Neuroscience"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"6082","DOI":"10.1111\/jcmm.16505","article-title":"DYRK1A phosphorylates MEF2D and decreases its transcriptional activity","volume":"25","author":"Wang","year":"2021","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0258-z","article-title":"Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death","volume":"12","author":"Yang","year":"2015","journal-title":"Journal of Neuroinflammation"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/86200\/elife-86200-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/86200\/elife-86200-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/86200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:15:23Z","timestamp":1697058923000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/86200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,17]]},"references-count":36,"alternative-id":["10.7554\/eLife.86200"],"URL":"https:\/\/doi.org\/10.7554\/elife.86200","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.12.09.519777","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2022.12.09.519777","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.86200.sa1","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.86200.sa0","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.86200.sa2","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,17]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"e86200"}}