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Here, we present two main findings elucidating mechanisms of corticothalamic information transfer during conscious states. First, we identify a highly preserved spectral channel of cortical-thalamic communication that is present during conscious states, but which is diminished during the loss of consciousness and enhanced during psychedelic states. Specifically, we show that in humans, mice, and rats, information sent from either the cortex or thalamus via \u03b4\/\u03b8\/\u03b1 waves (\u223c1\u201313 Hz) is consistently encoded by the other brain region by high \u03b3 waves (52\u2013104 Hz); moreover, unconsciousness induced by propofol anesthesia or generalized spike-and-wave seizures diminishes this cross-frequency communication, whereas the psychedelic 5-methoxy-\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    -dimethyltryptamine (5-MeO-DMT) enhances this low-to-high frequency interregional communication. Second, we leverage numerical simulations and neural electrophysiology recordings from the thalamus and cortex of human patients, rats, and mice to show that these changes in cross-frequency cortical-thalamic information transfer may be mediated by excursions of low-frequency thalamocortical electrodynamics toward\/away from edge-of-chaos criticality, or the phase transition from stability to chaos. Overall, our findings link thalamic-cortical communication to consciousness, and further offer a novel, mathematically well-defined framework to explain the disruption to thalamic-cortical information transfer during unconscious states.\n                  <\/jats:p>","DOI":"10.7554\/elife.86547","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T07:15:10Z","timestamp":1702624510000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.86547","source":"Crossref","is-referenced-by-count":24,"title":["Criticality supports cross-frequency cortical-thalamic information transfer during conscious states"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-8937","authenticated-orcid":true,"given":"Daniel","family":"Toker","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/046rm7j60","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurology, University of California, Los 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