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However, the mechanisms of how morphogenesis and functions along the hippocampal dorsoventral axis are differentiated and integrated are still largely unclear. Here, we show that\n                    <jats:italic>Nr2f1<\/jats:italic>\n                    and\n                    <jats:italic>Nr2f2<\/jats:italic>\n                    genes are distinctively expressed in the dorsal and ventral hippocampus, respectively. The loss of\n                    <jats:italic>Nr2f2<\/jats:italic>\n                    results in ectopic CA1\/CA3 domains in the ventral hippocampus. The deficiency of\n                    <jats:italic>Nr2f1<\/jats:italic>\n                    leads to the failed specification of dorsal CA1, among which there are place cells. The deletion of both\n                    <jats:italic>Nr2f<\/jats:italic>\n                    genes causes almost agenesis of the hippocampus with abnormalities of trisynaptic circuit and adult neurogenesis. Moreover,\n                    <jats:italic>Nr2f1\/2<\/jats:italic>\n                    may cooperate to guarantee appropriate morphogenesis and function of the hippocampus by regulating the\n                    <jats:italic>Lhx5-Lhx2<\/jats:italic>\n                    axis. Our findings revealed a novel mechanism that\n                    <jats:italic>Nr2f1<\/jats:italic>\n                    and\n                    <jats:italic>Nr2f2<\/jats:italic>\n                    converge to govern the differentiation and integration of distinct characteristics of the hippocampus in mice.\n                  <\/jats:p>","DOI":"10.7554\/elife.86940","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T11:32:53Z","timestamp":1683718373000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.86940","source":"Crossref","is-referenced-by-count":5,"title":["The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes"],"prefix":"10.7554","volume":"12","author":[{"given":"Xiong","family":"Yang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ar8rn06","id-type":"ROR","asserted-by":"publisher"}],"name":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ar8rn06","id-type":"ROR","asserted-by":"publisher"}],"name":"Precise Genome Engineering Center, School of Life Sciences, Guangzhou University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01n179w26","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangzhou Laboratory\/Bioland Laboratory","place":["Guangzhou, China"]},{"id":[{"id":"https:\/\/ror.org\/02c31t502","id-type":"ROR","asserted-by":"publisher"}],"name":"CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Institutes of Biomedicine and Health, Chinese Academy of Sciences","place":["Guangzhou, 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