{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:41:24Z","timestamp":1787568084204,"version":"build-2736575974"},"reference-count":66,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Human Resource Development","doi-asserted-by":"publisher","award":["STARS"],"award-info":[{"award-number":["STARS"]}],"id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["NPDF"],"award-info":[{"award-number":["NPDF"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Research Foundation","doi-asserted-by":"publisher","award":["211416Pj01H"],"award-info":[{"award-number":["211416Pj01H"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022\u201301262"],"award-info":[{"award-number":["2022\u201301262"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["PR2021-0026"],"award-info":[{"award-number":["PR2021-0026"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003849","name":"IngaBritt och Arne Lundbergs Forskningsstiftelse","doi-asserted-by":"publisher","award":["LU2020-0017"],"award-info":[{"award-number":["LU2020-0017"]}],"id":[{"id":"10.13039\/501100003849","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LUA\/ALF and the VAJRA Faculty Scheme","award":["(VJR\/2021\/000008"],"award-info":[{"award-number":["(VJR\/2021\/000008"]}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA,\n                    <jats:italic>PITAR<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    53\n                    <jats:italic>I<\/jats:italic>\n                    nactivating\n                    <jats:italic>T<\/jats:italic>\n                    RIM28\n                    <jats:italic>A<\/jats:italic>\n                    ssociated\n                    <jats:italic>R<\/jats:italic>\n                    NA), as an inhibitor of p53.\n                    <jats:italic>PITAR<\/jats:italic>\n                    is an oncogenic Cancer\/testis lncRNA and is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We establish that\n                    <jats:italic>TRIM28<\/jats:italic>\n                    mRNA, which encodes a p53-specific E3 ubiquitin ligase, is a direct target of\n                    <jats:italic>PITAR. PITAR<\/jats:italic>\n                    interaction with\n                    <jats:italic>TRIM28<\/jats:italic>\n                    RNA stabilized\n                    <jats:italic>TRIM28<\/jats:italic>\n                    mRNA, which resulted in increased TRIM28 protein levels and reduced p53 steady-state levels due to enhanced p53 ubiquitination. DNA damage activated\n                    <jats:italic>PITAR<\/jats:italic>\n                    , in addition to p53, in a p53-independent manner, thus creating an incoherent feedforward loop to inhibit the DNA damage response by p53. While\n                    <jats:italic>PITAR<\/jats:italic>\n                    silencing inhibited the growth of WT p53 containing GSCs in vitro and reduced glioma tumor growth in vivo, its overexpression enhanced the tumor growth in a\n                    <jats:italic>TRIM28<\/jats:italic>\n                    -dependent manner and promoted resistance to Temozolomide. Thus, we establish an alternate way of p53 inactivation by\n                    <jats:italic>PITAR<\/jats:italic>\n                    , which maintains low p53 levels in normal cells and attenuates the DNA damage response by p53. Finally, we propose\n                    <jats:italic>PITAR<\/jats:italic>\n                    as a potential GBM therapeutic target.\n                  <\/jats:p>","DOI":"10.7554\/elife.88256","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T12:47:25Z","timestamp":1688388445000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.88256","source":"Crossref","is-referenced-by-count":3,"title":["PITAR, a DNA damage-inducible cancer\/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8743-4711","authenticated-orcid":true,"given":"Samarjit","family":"Jana","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Cell Biology, Indian Institute of Science Bangalore","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Mainak","family":"Mondal","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Cell Biology, Indian Institute of Science Bangalore","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Sagar","family":"Mahale","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01tm6cn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg","place":["Gothenburg, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Bhavana","family":"Gupta","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Cell Biology, Indian Institute of Science Bangalore","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Kaval Reddy","family":"Prasasvi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Cell Biology, Indian Institute of Science Bangalore","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Lekha","family":"Kandasami","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Cell Biology, Indian Institute of Science Bangalore","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Neha","family":"Jha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Cell Biology, Indian Institute of Science Bangalore","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2985-9053","authenticated-orcid":true,"given":"Abhishek","family":"Chowdhury","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Cell Biology, Indian Institute of Science Bangalore","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Vani","family":"Santosh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0405n5e57","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuropathology, National Institute of Mental Health and Neurosciences","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Chandrasekhar","family":"Kanduri","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01tm6cn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg","place":["Gothenburg, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-9741","authenticated-orcid":true,"given":"Kumaravel","family":"Somasundaram","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04dese585","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Cell Biology, Indian Institute of Science Bangalore","place":["Bangalore, India"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrc.2017.99","type":"journal-article","article-title":"Non-coding RNA networks in cancer","volume":"18","author":"Anastasiadou","year":"2018","journal-title":"Nature Reviews. Cancer"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2021.100411","type":"journal-article","article-title":"Insights into how H19 works in glioma cells. A review article","volume":"28","author":"Azab","year":"2021","journal-title":"Cancer Treatment and Research Communications"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000935","type":"journal-article","article-title":"Transcriptional regulation by p53","volume":"2","author":"Beckerman","year":"2010","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.tcb.2011.10.006","type":"journal-article","article-title":"Deconstructing p53 transcriptional networks in tumor suppression","volume":"22","author":"Bieging","year":"2012","journal-title":"Trends in Cell Biology"},{"key":"bib5","type":"software","article-title":"Picard toolkit","author":"Broad Institute","year":"2019","unstructured":"Broad Institute. 2019. Picard toolkit. Broad Institute. v1.73. https:\/\/broadinstitute.github.io\/picard\/."},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1101\/gad.17446611","type":"journal-article","article-title":"Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses","volume":"25","author":"Cabili","year":"2011","journal-title":"Genes & Development"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"9947","DOI":"10.1093\/nar\/gkx600","type":"journal-article","article-title":"Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation","volume":"45","author":"Chen","year":"2017","journal-title":"Nucleic Acids Research"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2026813118","type":"journal-article","article-title":"Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP","volume":"118","author":"Chen","year":"2021","journal-title":"PNAS"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"472","DOI":"10.4161\/cc.9.3.10556","type":"journal-article","article-title":"Mechanism of p53 stabilization by ATM after DNA damage","volume":"9","author":"Cheng","year":"2010","journal-title":"Cell Cycle"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.3791\/3912","type":"journal-article","article-title":"Chromatin isolation by RNA purification (ChIRP)","volume":"25","author":"Chu","year":"2012","journal-title":"Journal of Visualized Experiments"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0374-4","type":"journal-article","article-title":"The complexity of TRIM28 contribution to cancer","volume":"24","author":"Czerwi\u0144ska","year":"2017","journal-title":"Journal of Biomedical Science"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"863","DOI":"10.18632\/oncotarget.13273","type":"journal-article","article-title":"TRIM28 multi-domain protein regulates cancer stem cell population in breast tumor development","volume":"8","author":"Czerwi\u0144ska","year":"2017","journal-title":"Oncotarget"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1101\/gr.132159.111","type":"journal-article","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Research"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature11233","type":"journal-article","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-p","type":"journal-article","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"el-Deiry","year":"1993","journal-title":"Cell"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.cell.2014.08.018","type":"journal-article","article-title":"RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites","volume":"159","author":"Engreitz","year":"2014","journal-title":"Cell"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nm1784","type":"journal-article","article-title":"Expression of a noncoding RNA is elevated in Alzheimer\u2019s disease and drives rapid feed-forward regulation of beta-secretase","volume":"14","author":"Faghihi","year":"2008","journal-title":"Nature Medicine"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07475-5","type":"journal-article","article-title":"TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression","volume":"9","author":"Fong","year":"2018","journal-title":"Nature Communications"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.molonc.2011.02.001","type":"journal-article","article-title":"The biology of cancer testis antigens: putative function, regulation and therapeutic potential","volume":"5","author":"Fratta","year":"2011","journal-title":"Molecular Oncology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1093\/bioinformatics\/bty208","type":"journal-article","article-title":"MechRNA: prediction of lncRNA mechanisms from RNA-RNA and RNA-protein interactions","volume":"34","author":"Gawronski","year":"2018","journal-title":"Bioinformatics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"15772","DOI":"10.18632\/oncotarget.4694","type":"journal-article","article-title":"Oncogenic cancer\/testis antigens: Prime candidates for immunotherapy","volume":"6","author":"Gjerstorff","year":"2015","journal-title":"Oncotarget"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nature09701","type":"journal-article","article-title":"lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3\u2019 UTRs via Alu elements","volume":"470","author":"Gong","year":"2011","journal-title":"Nature"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/387296a0","type":"journal-article","article-title":"Mdm2 promotes the rapid degradation of p53","volume":"387","author":"Haupt","year":"1997","journal-title":"Nature"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jim.2009.06.008","type":"journal-article","article-title":"ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays","volume":"347","author":"Hu","year":"2009","journal-title":"Journal of Immunological Methods"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/ng.3192","type":"journal-article","article-title":"The landscape of long noncoding RNAs in the human transcriptome","volume":"47","author":"Iyer","year":"2015","journal-title":"Nature Genetics"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1080\/15476286.2020.1770981","type":"journal-article","article-title":"Emerging roles of long non-coding RNAs in the p53 network","volume":"17","author":"Jain","year":"2020","journal-title":"RNA Biology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11661","type":"journal-article","article-title":"Control of somatic tissue differentiation by the long non-coding RNA TINCR","volume":"493","author":"Kretz","year":"2013","journal-title":"Nature"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/387299a0","type":"journal-article","article-title":"Regulation of p53 stability by Mdm2","volume":"387","author":"Kubbutat","year":"1997","journal-title":"Nature"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/s0092-8674(00)81871-1","type":"journal-article","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1016\/j.celrep.2017.08.041","type":"journal-article","article-title":"Long noncoding RNA PURPL suppresses basal p53 levels and promotes tumorigenicity in colorectal cancer","volume":"20","author":"Li","year":"2017","journal-title":"Cell Reports"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-022-00385-x","type":"journal-article","article-title":"lncRNA PVT1: A novel oncogene in multiple cancers","volume":"27","author":"Li","year":"2022","journal-title":"Cellular & Molecular Biology Letters"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s13277-015-3779-2","type":"journal-article","article-title":"H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation","volume":"37","author":"Liu","year":"2016","journal-title":"Tumour Biology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"15787","DOI":"10.18632\/oncotarget.7487","type":"journal-article","article-title":"LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.omtn.2021.11.012","type":"journal-article","article-title":"LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24","volume":"27","author":"Lv","year":"2022","journal-title":"Molecular Therapy. Nucleic Acids"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32537-0","type":"journal-article","article-title":"HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells","volume":"13","author":"Mahale","year":"2022","journal-title":"Nature Communications"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"W435","DOI":"10.1093\/nar\/gkx279","type":"journal-article","article-title":"IntaRNA 2.0: Enhanced and customizable prediction of RNA-RNA interactions","volume":"45","author":"Mann","year":"2017","journal-title":"Nucleic Acids Research"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","type":"journal-article","article-title":"Long non-coding RNAs: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1158\/0008-5472.CAN-19-3499","type":"journal-article","article-title":"Subcellular distribution of p53 by the p53-responsive lncRNA NBAT1 determines chemotherapeutic response in neuroblastoma","volume":"81","author":"Mitra","year":"2021","journal-title":"Cancer Research"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/humu.10081","type":"journal-article","article-title":"The IARC TP53 database: New online mutation analysis and recommendations to users","volume":"19","author":"Olivier","year":"2002","journal-title":"Human Mutation"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"29548","DOI":"10.18632\/oncotarget.25434","type":"journal-article","article-title":"Genetic landscape of long noncoding RNA (lncRNAs) in glioblastoma: Identification of complex lncRNA regulatory networks and clinically relevant lncRNAs in glioblastoma","volume":"9","author":"Paul","year":"2018","journal-title":"Oncotarget"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.612393","type":"journal-article","article-title":"Long non-coding RNAs in cancer: Implications for diagnosis, prognosis, and therapy","volume":"7","author":"Qian","year":"2020","journal-title":"Frontiers in Medicine"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/hep.30793","type":"journal-article","article-title":"Long noncoding RNA p53-stabilizing and activating RNA promotes p53 signaling by inhibiting heterogeneous nuclear ribonucleoprotein K deSUMOylation and suppresses hepatocellular carcinoma","volume":"71","author":"Qin","year":"2020","journal-title":"Hepatology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/nrm2395","type":"journal-article","article-title":"Transcriptional control of human p53-regulated genes","volume":"9","author":"Riley","year":"2008","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/s0092-8674(00)80416-x","type":"journal-article","article-title":"DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2","volume":"91","author":"Shieh","year":"1997","journal-title":"Cell"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.cell.2019.10.017","type":"journal-article","article-title":"The role of non-coding RNAs in oncology","volume":"179","author":"Slack","year":"2019","journal-title":"Cell"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","type":"journal-article","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"6447","DOI":"10.2147\/OTT.S168630","type":"journal-article","article-title":"TRIM28 is overexpressed in glioma and associated with tumor progression","volume":"11","author":"Su","year":"2018","journal-title":"OncoTargets and Therapy"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","type":"journal-article","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"PNAS"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.cell.2014.02.030","type":"journal-article","article-title":"Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells","volume":"157","author":"Suv\u00e0","year":"2014","journal-title":"Cell"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1101\/gad.13.2.152","type":"journal-article","article-title":"A role for ATR in the DNA damage-induced phosphorylation of p53","volume":"13","author":"Tibbetts","year":"1999","journal-title":"Genes & Development"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1093\/bioinformatics\/btu169","type":"journal-article","article-title":"PRADA: pipeline for RNA sequencing data analysis","volume":"30","author":"Torres-Garc\u00eda","year":"2014","journal-title":"Bioinformatics"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.molcel.2019.07.025","type":"journal-article","article-title":"Conserved Pseudoknots in lncRNA MEG3 Are essential for stimulation of the p53 pathway","volume":"75","author":"Uroda","year":"2019","journal-title":"Molecular Cell"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/onc.2017.351","type":"journal-article","article-title":"Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance","volume":"37","author":"Visvanathan","year":"2018","journal-title":"Oncogene"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35042675","type":"journal-article","article-title":"Surfing the p53 network","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nrc864","type":"journal-article","article-title":"Live or let die: The cell\u2019s response to p53","volume":"2","author":"Vousden","year":"2002","journal-title":"Nature Reviews Cancer"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrm2147","type":"journal-article","article-title":"p53 in health and disease","volume":"8","author":"Vousden","year":"2007","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1038\/sj.emboj.7600791","type":"journal-article","article-title":"MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation","volume":"24","author":"Wang","year":"2005","journal-title":"The EMBO Journal"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"7567","DOI":"10.12659\/MSM.916040","type":"journal-article","article-title":"Functional roles of long non-coding RNAs (LncRNAs) in glioma stem cells","volume":"25","author":"Wang","year":"2019","journal-title":"Medical Science Monitor"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"11440","DOI":"10.1080\/21655979.2022.2065947","type":"journal-article","article-title":"lncRNA H19 promotes glioblastoma multiforme development by activating autophagy by sponging miR-491-5p","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1101\/gad.7.7a.1126","type":"journal-article","article-title":"The p53-mdm-2 autoregulatory feedback loop","volume":"7","author":"Wu","year":"1993","journal-title":"Genes & Development"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/j.bbadis.2018.02.022","type":"journal-article","article-title":"PVT1 regulates the malignant behaviors of human glioma cells by targeting miR-190a-5p and miR-488-3p","volume":"1864","author":"Xue","year":"2018","journal-title":"Biochimica et Biophysica Acta. Molecular Basis of Disease"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.omtn.2021.03.018","type":"journal-article","article-title":"LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics","volume":"24","author":"Yadav","year":"2021","journal-title":"Molecular Therapy. Nucleic Acids"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1042\/EBC20200032","type":"journal-article","article-title":"Non-coding RNA in cancer","volume":"65","author":"Yan","year":"2021","journal-title":"Essays in Biochemistry"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"12245","DOI":"10.1073\/pnas.0813088106","type":"journal-article","article-title":"Cell fate decision mediated by p53 pulses","volume":"106","author":"Zhang","year":"2009","journal-title":"PNAS"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.canlet.2016.04.030","type":"journal-article","article-title":"Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis","volume":"380","author":"Zhu","year":"2016","journal-title":"Cancer Letters"},{"key":"dataset1","doi-asserted-by":"publisher","DOI":"10.5061\/dryad.3j9kd51t7","type":"dataset","article-title":"PITAR, a DNA damage-inducible Cancer\/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA","volume-title":"Dryad Digital Repository","author":"Samarjit","year":"2024","unstructured":"Samarjit J, Mainak M, Sagar M, Bhavana G, Kaval Reddy P, Lekha K, Neha J, Abhishek C, Vani S, Chandrasekhar K, Kumaravel S. 2024. PITAR, a DNA damage-inducible Cancer\/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA. Dryad Digital Repository."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/88256\/elife-88256-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/88256\/elife-88256-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/88256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:13:28Z","timestamp":1787566408000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/88256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":66,"alternative-id":["10.7554\/eLife.88256"],"URL":"https:\/\/doi.org\/10.7554\/elife.88256","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.04.11.536370","asserted-by":"subject"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.88256.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.88256.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.88256.2","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"doi","id":"10.5061\/dryad.3j9kd51t7","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP88256"}}