{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:42:46Z","timestamp":1792197766915,"version":"4.4.0"},"reference-count":105,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI157513"],"award-info":[{"award-number":["AI157513"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI136523"],"award-info":[{"award-number":["AI136523"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    The white-footed deermouse\n                    <jats:italic>Peromyscus leucopus<\/jats:italic>\n                    , a long-lived rodent, is a key reservoir in North America for agents of several zoonoses, including Lyme disease, babesiosis, anaplasmosis, and a viral encephalitis. While persistently infected, this deermouse is without apparent disability or diminished fitness. For a model for inflammation elicited by various pathogens, the endotoxin lipopolysaccharide (LPS) was used to compare genome-wide transcription in blood by\n                    <jats:italic>P. leucopus<\/jats:italic>\n                    ,\n                    <jats:italic>Mus musculus,<\/jats:italic>\n                    and\n                    <jats:italic>Rattus norvegicus<\/jats:italic>\n                    and adjusted for white cell concentrations. Deermice were distinguished from the mice and rats by LPS response profiles consistent with non-classical monocytes and alternatively-activated macrophages. LPS-treated\n                    <jats:italic>P. leucopus<\/jats:italic>\n                    , in contrast to mice and rats, also displayed little transcription of interferon-gamma and lower magnitude fold-changes in type 1 interferon-stimulated genes. These characteristics of\n                    <jats:italic>P. leucopus<\/jats:italic>\n                    were also noted in a\n                    <jats:italic>Borrelia hermsii<\/jats:italic>\n                    infection model. The phenomenon was associated with comparatively reduced transcription of endogenous retrovirus sequences and cytoplasmic pattern recognition receptors in the deermice. The results reveal a mechanism for infection tolerance in this species and perhaps other animal reservoirs for agents of human disease.\n                  <\/jats:p>","DOI":"10.7554\/elife.90135","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:14:59Z","timestamp":1692947699000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.90135","source":"Crossref","is-referenced-by-count":16,"title":["The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat"],"prefix":"10.7554","volume":"12","author":[{"given":"Ana","family":"Milovic","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04gyf1771","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology & Molecular Genetics, University of California, Irvine","place":["Irvine, United 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