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During terminal erythropoiesis, these cells incorporate large amounts of iron in order to generate hemoglobin and ultimately undergo enucleation to become mature red blood cells, ultimately delivering oxygen in the circulation. Thus, erythropoiesis is a finely tuned, multifaceted process requiring numerous properly timed physiological events to maintain efficient production of 2 million red blood cells per second in steady state. Iron is required for normal functioning in all human cells, the erythropoietic compartment consuming the majority in light of the high iron requirements for hemoglobin synthesis. Recent evidence regarding the crosstalk between erythropoiesis and iron metabolism sheds light on the regulation of iron availability by erythroblasts and the consequences of insufficient as well as excess iron on erythroid lineage proliferation and differentiation. In addition, significant progress has been made in our understanding of dysregulated iron metabolism in various congenital and acquired malignant and non-malignant diseases. Finally, we report several actual as well as theoretical opportunities for translating the recently acquired robust mechanistic understanding of iron metabolism regulation to improve management of patients with disordered erythropoiesis, such as anemia of chronic inflammation, \u03b2-thalassemia, polycythemia vera, and myelodysplastic syndromes.<\/jats:p>","DOI":"10.7554\/elife.90189","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T03:15:11Z","timestamp":1691378111000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.90189","source":"Crossref","is-referenced-by-count":37,"title":["Normal and dysregulated crosstalk between iron metabolism and erythropoiesis"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3496-3783","authenticated-orcid":true,"given":"Yelena","family":"Ginzburg","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04a9tmd77","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"An","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xvcf081","id-type":"ROR","asserted-by":"publisher"}],"name":"LFKRI, New York Blood Center","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Rivella","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Division of Hematology, The Children\u2019s Hospital of Philadelphia","place":["Philadelphia, United States"]},{"id":[{"id":"https:\/\/ror.org\/00b30xv10","id-type":"ROR","asserted-by":"publisher"}],"name":"Cell and Molecular Biology affinity group (CAMB), University of Pennsylvania","place":["Philadelphia, United States"]},{"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"publisher"}],"name":"Raymond G. 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