{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:43:28Z","timestamp":1790203408035,"version":"4.1.0"},"reference-count":47,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI151004"],"award-info":[{"award-number":["R01AI151004"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001589","name":"Environmental Protection Agency","doi-asserted-by":"publisher","award":["RD84020401"],"award-info":[{"award-number":["RD84020401"]}],"id":[{"id":"10.13039\/501100001589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI143698-01A1"],"award-info":[{"award-number":["1R01AI143698-01A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Each year, hundreds of millions of people are infected with arboviruses such as dengue, yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious mosquito\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    . Traditional control measures have proven insufficient, necessitating innovations. In response, here we generate a next-generation CRISPR-based precision-guided sterile insect technique (pgSIT) for\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    that disrupts genes essential for sex determination and fertility, producing predominantly sterile males that can be deployed at any life stage. Using mathematical models and empirical testing, we demonstrate that released pgSIT males can effectively compete with, suppress, and eliminate caged mosquito populations. This versatile species-specific platform has the potential for field deployment to effectively control wild populations of disease vectors.\n                  <\/jats:p>","DOI":"10.7554\/elife.90199","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T11:32:04Z","timestamp":1695814324000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.90199","source":"Crossref","is-referenced-by-count":11,"title":["Targeting sex determination to suppress mosquito populations"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7578-4968","authenticated-orcid":true,"given":"Ming","family":"Li","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01an7q238","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Biological Sciences, Department of Cell and Developmental Biology, University of California, Berkeley","place":["Berkeley, United 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Yang T, Benetta ED, Brogan DJ, Antoshechkin I, S\u00e1nchez HM, Zhan Y, DeBeaubien NA, Loh YM, Su MP, Montell C, Marshall JM, Akbari OS. 2023. Targeting sex determination to suppress mosquito populations. NCBI BioProject. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/?term=PRJNA942966. 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