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In addition to these symptoms, PD patients often suffer from non-motor comorbidities including sleep and psychiatric disturbances, which are thought to depend on concomitant alterations of serotonergic and noradrenergic transmission. A primary locus of serotonergic neurons is the dorsal raphe nucleus (DRN), providing brain-wide serotonergic input. Here, we identified electrophysiological and morphological parameters to classify serotonergic and dopaminergic neurons in the murine DRN under control conditions and in a PD model, following striatal injection of the catecholamine toxin, 6-hydroxydopamine (6-OHDA). Electrical and morphological properties of both neuronal populations were altered by 6-OHDA. In serotonergic neurons, most changes were reversed when 6-OHDA was injected in combination with desipramine, a noradrenaline (NA) reuptake inhibitor, protecting the noradrenergic terminals. Our results show that the depletion of both NA and dopamine in the 6-OHDA mouse model causes changes in the DRN neural circuitry.<\/jats:p>","DOI":"10.7554\/elife.90278","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T09:09:37Z","timestamp":1692608977000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.90278","source":"Crossref","is-referenced-by-count":3,"title":["Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-8478","authenticated-orcid":true,"given":"Laura","family":"Boi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, Karolinska Institute","place":["Stockholm, 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