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Absence seizures are characterized by spike-and-wave discharges on the electroencephalogram associated with a transient alteration of consciousness. However, it is still unknown how the brain responds to external stimuli during and outside of seizures. This study aimed to investigate responsiveness to visual and somatosensory stimulation in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a well-established rat model for absence epilepsy. Animals were imaged under non-curarized awake state using a quiet, zero echo time, functional magnetic resonance imaging (fMRI) sequence. Sensory stimulations were applied during interictal and ictal periods. Whole-brain hemodynamic responses were compared between these two states. Additionally, a mean-field simulation model was used to explain the changes of neural responsiveness to visual stimulation between states. During a seizure, whole-brain responses to both sensory stimulations were suppressed and spatially hindered. In the cortex, hemodynamic responses were negatively polarized during seizures, despite the application of a stimulus. The mean-field simulation revealed restricted propagation of activity due to stimulation and agreed well with fMRI findings. Results suggest that sensory processing is hindered or even suppressed by the occurrence of an absence seizure, potentially contributing to decreased responsiveness during this absence epileptic process.<\/jats:p>","DOI":"10.7554\/elife.90318","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T18:06:07Z","timestamp":1697479567000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.90318","source":"Crossref","is-referenced-by-count":10,"title":["EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4733-5014","authenticated-orcid":true,"given":"Petteri","family":"Stenroos","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04as3rk94","id-type":"ROR","asserted-by":"publisher"}],"name":"University Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences","place":["Grenoble, France"]},{"id":[{"id":"https:\/\/ror.org\/00cyydd11","id-type":"ROR","asserted-by":"publisher"}],"name":"A.I. 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