{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:25:39Z","timestamp":1788308739548,"version":"build-2803163510"},"reference-count":155,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005237","name":"Helen Hay Whitney Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005237","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Johns Hopkins University","award":["CMDB graduate program"],"award-info":[{"award-number":["CMDB graduate program"]}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Highly potent animal stem cells either self renew or launch complex differentiation programs, using mechanisms that are only partly understood.\n                    <jats:italic>Drosophila<\/jats:italic>\n                    female germline stem cells (GSCs) perpetuate without change over evolutionary time and generate cystoblast daughters that develop into nurse cells and oocytes. Cystoblasts initiate differentiation by generating a transient syncytial state, the germline cyst, and by increasing pericentromeric H3K9me3 modification, actions likely to suppress transposable element activity. Relatively open GSC chromatin is further restricted by Polycomb repression of testis or somatic cell-expressed genes briefly active in early female germ cells. Subsequently, Neijre\/CBP and Myc help upregulate growth and reprogram GSC metabolism by altering mitochondrial transmembrane transport, gluconeogenesis, and other processes. In all these respects GSC differentiation resembles development of the totipotent zygote. We propose that the totipotent stem cell state was shaped by the need to resist transposon activity over evolutionary timescales.\n                  <\/jats:p>","DOI":"10.7554\/elife.90509","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T08:15:57Z","timestamp":1693469757000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.90509","source":"Crossref","is-referenced-by-count":21,"title":["Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells"],"prefix":"10.7554","volume":"12","author":[{"given":"Liang-Yu","family":"Pang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"publisher"}],"name":"Howard Hughes Medical Institute, Carnegie Institution for Science","place":["Baltimore, United 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