{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:38:29Z","timestamp":1785425909301,"version":"3.56.0"},"reference-count":57,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1181580"],"award-info":[{"award-number":["1181580"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bodhi Education Fund","award":["Fellowship"],"award-info":[{"award-number":["Fellowship"]}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    <jats:italic>ZRANB1<\/jats:italic>\n                    (human Trabid) missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how Trabid regulates neurodevelopment is not understood. We have characterized these patient mutations in cells and mice to identify a key role for Trabid in the regulation of neurite growth. One of the patient mutations flanked the catalytic cysteine of Trabid and its deubiquitylating (DUB) activity was abrogated. The second variant retained DUB activity, but failed to bind STRIPAK, a large multiprotein assembly implicated in cytoskeleton organization and neural development.\n                    <jats:italic>Zranb1<\/jats:italic>\n                    knock-in mice harboring either of these patient mutations exhibited reduced neuronal and glial cell densities in the brain and a motor deficit consistent with fewer dopaminergic neurons and projections. Mechanistically, both DUB-impaired and STRIPAK-binding-deficient Trabid variants impeded the trafficking of adenomatous polyposis coli (APC) to microtubule plus-ends. Consequently, the formation of neuronal growth cones and the trajectory of neurite outgrowth from mutant midbrain progenitors were severely compromised. We propose that STRIPAK recruits Trabid to deubiquitylate APC, and that in cells with mutant Trabid, APC becomes hyperubiquitylated and mislocalized causing impaired organization of the cytoskeleton that underlie the neuronal and developmental phenotypes.\n                  <\/jats:p>","DOI":"10.7554\/elife.90796","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T11:48:11Z","timestamp":1697024891000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.90796","source":"Crossref","is-referenced-by-count":2,"title":["Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4998-2220","authenticated-orcid":true,"given":"Daniel","family":"Frank","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-9701","authenticated-orcid":true,"given":"Maria","family":"Bergamasco","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-9167","authenticated-orcid":true,"given":"Michael J","family":"Mlodzianoski","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Dynamic Imaging, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kueh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Melbourne Advanced Genome Editing Centre, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]},{"name":"Olivia Newton-John Cancer Research Institute","place":["Heidelberg, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01rxfrp27","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Cancer Medicine, La Trobe University","place":["Heidelberg, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7340-7412","authenticated-orcid":true,"given":"Ellen","family":"Tsui","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Histology Facility, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1004-9435","authenticated-orcid":true,"given":"Cathrine","family":"Hall","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Inflammation Division, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kastrappis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016899r71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3853-9381","authenticated-orcid":true,"given":"Anne Kathrin","family":"Voss","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-5727","authenticated-orcid":true,"given":"Catriona","family":"McLean","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01wddqe20","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Anatomical Pathology, The Alfred Hospital","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-6683","authenticated-orcid":true,"given":"Maree","family":"Faux","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/048fyec77","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuro-Oncology Group, Murdoch Children\u2019s Research Institute","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-0221","authenticated-orcid":true,"given":"Kelly L","family":"Rogers","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Dynamic Imaging, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3108-8805","authenticated-orcid":true,"given":"Bang","family":"Tran","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016899r71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8607-4849","authenticated-orcid":true,"given":"Elizabeth","family":"Vincan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016899r71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity","place":["Melbourne, Australia"]},{"id":[{"id":"https:\/\/ror.org\/005bvs909","id-type":"ROR","asserted-by":"publisher"}],"name":"The Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Komander","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Dewson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-4112","authenticated-orcid":true,"given":"Hoanh","family":"Tran","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01b6kha49","id-type":"ROR","asserted-by":"publisher"}],"name":"Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/01ej9dk98","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Biology, The University of Melbourne","place":["Parkville, Australia"]},{"id":[{"id":"https:\/\/ror.org\/016899r71","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1091\/mbc.E13-10-0609","article-title":"\u0391-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion","volume":"25","author":"Aguilar","year":"2014","journal-title":"Molecular Biology of the Cell"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/978-0-387-46954-6_11","article-title":"Neural crest and the development of the enteric nervous system","volume":"589","author":"Anderson","year":"2006","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1016\/j.celrep.2015.02.002","article-title":"An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo","volume":"10","author":"Aubrey","year":"2015","journal-title":"Cell Reports"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-9-54","article-title":"Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration","volume":"9","author":"Bai","year":"2011","journal-title":"BMC Biology"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.225805","article-title":"Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration","volume":"132","author":"Bance","year":"2019","journal-title":"Journal of Cell Science"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"E10928","DOI":"10.1073\/pnas.1713535114","article-title":"STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo","volume":"114","author":"Bazzi","year":"2017","journal-title":"PNAS"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe2116","article-title":"Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation","volume":"7","author":"Beck","year":"2021","journal-title":"Science Advances"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrm806","article-title":"The subcellular destinations of APC proteins","volume":"3","author":"Bienz","year":"2002","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2004.08.012","article-title":"Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche","volume":"118","author":"Blanpain","year":"2004","journal-title":"Cell"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1016\/j.bbamcr.2008.04.017","article-title":"The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members","volume":"1783","author":"Breitman","year":"2008","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.18632\/oncotarget.1306","article-title":"HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia","volume":"4","author":"Brumatti","year":"2013","journal-title":"Oncotarget"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27705-7","article-title":"Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly","volume":"13","author":"Carpentieri","year":"2022","journal-title":"Nature Communications"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"19970","DOI":"10.1074\/jbc.M909782199","article-title":"Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain","volume":"275","author":"Castets","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21715-1","article-title":"VPS34 K29\/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism","volume":"12","author":"Chen","year":"2021","journal-title":"Nature Communications"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0112-8","article-title":"Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function","volume":"20","author":"Clague","year":"2019","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"14033","DOI":"10.1073\/pnas.0605899103","article-title":"The cephalic neural crest exerts a critical effect on forebrain and midbrain development","volume":"103","author":"Creuzet","year":"2006","journal-title":"PNAS"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature14135","article-title":"Large-scale discovery of novel genetic causes of developmental disorders","volume":"519","author":"Deciphering Developmental Disorders","year":"2015","journal-title":"Nature"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nature19356","article-title":"High-throughput discovery of novel developmental phenotypes","volume":"537","author":"Dickinson","year":"2016","journal-title":"Nature"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/s0962-8924(01)02069-4","article-title":"The adenomatous polyposis coli protein: in the limelight out at the edge","volume":"11","author":"Dikovskaya","year":"2001","journal-title":"Trends in Cell Biology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41580-018-0067-1","article-title":"Actin-microtubule crosstalk in cell biology","volume":"20","author":"Dogterom","year":"2019","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202003091","article-title":"Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion","volume":"219","author":"Efimova","year":"2020","journal-title":"The Journal of Cell Biology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.3390\/cells3041027","article-title":"Versatile roles of k63-linked ubiquitin chains in trafficking","volume":"3","author":"Erpapazoglou","year":"2014","journal-title":"Cells"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/nature01423","article-title":"Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity","volume":"421","author":"Etienne-Manneville","year":"2003","journal-title":"Nature"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1038\/nsmb.3475","article-title":"Mechanism and regulation of the Lys6-selective deubiquitinase USP30","volume":"24","author":"Gersch","year":"2017","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/ncb755","article-title":"A Drosophila APC tumour suppressor homologue functions in cellular adhesion","volume":"4","author":"Hamada","year":"2002","journal-title":"Nature Cell Biology"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015162","article-title":"The deubiquitinase TRABID stabilizes the K29\/K48-specific E3 ubiquitin ligase HECTD1","volume":"296","author":"Harris","year":"2021","journal-title":"The Journal of Biological Chemistry"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1038\/embor.2009.192","article-title":"Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities","volume":"10","author":"Hjerpe","year":"2009","journal-title":"EMBO Reports"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.biocel.2013.11.021","article-title":"STRIPAK complexes: structure, biological function, and involvement in human diseases","volume":"47","author":"Hwang","year":"2014","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nrm2731","article-title":"Breaking the chains: structure and function of the deubiquitinases","volume":"10","author":"Komander","year":"2009","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.celrep.2017.04.007","article-title":"NF-\u03baB Immunity in the Brain determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration","volume":"19","author":"Kounatidis","year":"2017","journal-title":"Cell Reports"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.molcel.2015.01.041","article-title":"K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin","volume":"58","author":"Kristariyanto","year":"2015","journal-title":"Molecular Cell"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1515\/hsz-2019-0173","article-title":"STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases","volume":"400","author":"K\u00fcck","year":"2019","journal-title":"Biological Chemistry"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"4729","DOI":"10.1096\/fj.201801882R","article-title":"Striatin is a novel modulator of cell adhesion","volume":"33","author":"Lahav-Ariel","year":"2019","journal-title":"FASEB Journal"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.molcel.2018.11.015","article-title":"Genome-wide CRISPR analysis identifies Substrate-Specific conjugation modules in ER-Associated degradation","volume":"73","author":"Leto","year":"2019","journal-title":"Molecular Cell"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nsmb.2169","article-title":"An ankyrin-repeat ubiquitin-binding domain determines TRABID\u2019s specificity for atypical ubiquitin chains","volume":"19","author":"Licchesi","year":"2011","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/ncb3083","article-title":"STRIPAK components determine mode of cancer cell migration and metastasis","volume":"17","author":"Madsen","year":"2015","journal-title":"Nature Cell Biology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1523\/JNEUROSCI.4029-08.2009","article-title":"Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum","volume":"29","author":"Matsuda","year":"2009","journal-title":"The Journal of Neuroscience"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1083\/jcb.134.1.165","article-title":"The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration","volume":"134","author":"N\u00e4thke","year":"1996","journal-title":"The Journal of Cell Biology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1083\/jcb.201606082","article-title":"A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation","volume":"216","author":"Neisch","year":"2017","journal-title":"The Journal of Cell Biology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/s41590-020-0758-6","article-title":"The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation","volume":"21","author":"Ng","year":"2020","journal-title":"Nature Immunology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.cell.2014.05.042","article-title":"APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly","volume":"158","author":"Preitner","year":"2014","journal-title":"Cell"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"5929","DOI":"10.1093\/emboj\/20.21.5929","article-title":"Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells","volume":"20","author":"Rosin-Arbesfeld","year":"2001","journal-title":"The EMBO Journal"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6180","article-title":"Drosophila Strip serves as a platform for early endosome organization during axon elongation","volume":"5","author":"Sakuma","year":"2014","journal-title":"Nature Communications"},{"key":"bib44","doi-asserted-by":"publisher","DOI":"10.1038\/srep17769","article-title":"A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability","volume":"5","author":"Sakuma","year":"2015","journal-title":"Scientific Reports"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1083\/jcb.201105101","article-title":"Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme","volume":"196","author":"Sarkar","year":"2012","journal-title":"The Journal of Cell Biology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1242\/jcs.149476","article-title":"Cortactin-binding protein 2 increases microtubule stability and regulates dendritic arborization","volume":"127","author":"Shih","year":"2014","journal-title":"Journal of Cell Science"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41583-019-0148-y","article-title":"Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis","volume":"20","author":"Silva","year":"2019","journal-title":"Nature Reviews. Neuroscience"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","article-title":"Defining the human deubiquitinating enzyme interaction landscape","volume":"138","author":"Sowa","year":"2009","journal-title":"Cell"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-1-62703-574-3_15","article-title":"Transplantation of fetal midbrain dopamine progenitors into a rodent model of Parkinson\u2019s disease","volume":"1059","author":"Thompson","year":"2013","journal-title":"Methods in Molecular Biology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1101\/gad.463208","article-title":"Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains","volume":"22","author":"Tran","year":"2008","journal-title":"Genes & Development"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"28552","DOI":"10.1074\/jbc.M112.387878","article-title":"Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the \u03b2-catenin destruction complex","volume":"287","author":"Tran","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1074\/jbc.M112.415240","article-title":"HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction","volume":"288","author":"Tran","year":"2013","journal-title":"The Journal of Biological Chemistry"},{"key":"bib53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16965-y","article-title":"The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis","volume":"12","author":"Vaughan","year":"2022","journal-title":"Scientific Reports"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"S110","DOI":"10.1016\/j.ydbio.2018.05.013","article-title":"Neurocristopathies: New insights 150 years after the neural crest discovery","volume":"444 Suppl 1","author":"Vega-Lopez","year":"2018","journal-title":"Developmental Biology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuron.2008.10.053","article-title":"The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex","volume":"61","author":"Yokota","year":"2009","journal-title":"Neuron"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/s41589-021-00823-5","article-title":"K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle","volume":"17","author":"Yu","year":"2021","journal-title":"Nature Chemical Biology"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.molcel.2014.03.035","article-title":"K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase regulates Protein Trafficking","volume":"54","author":"Yuan","year":"2014","journal-title":"Molecular Cell"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/90796\/elife-90796-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/90796\/elife-90796-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/90796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T08:00:55Z","timestamp":1702627255000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/90796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":57,"alternative-id":["10.7554\/eLife.90796"],"URL":"https:\/\/doi.org\/10.7554\/elife.90796","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.7554\/eLife.90796.2","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2023.07.17.549243","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2023.07.17.549243","asserted-by":"object"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.90796.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.90796.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.90796.2","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP90796"}}