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Previously, we proposed that such learning impairments can result from saturation of the plasticity mechanism (Nguyen-Vu et al., 2017), or, more generally, from a history-dependent change in the threshold for plasticity. This hypothesis was based on experimental results from mice lacking two class I major histocompatibility molecules, MHCI H2-K\n                    <jats:sup>b<\/jats:sup>\n                    and H2-D\n                    <jats:sup>b<\/jats:sup>\n                    (MHCI K\n                    <jats:sup>b<\/jats:sup>\n                    D\n                    <jats:sup>b\u2212\/\u2212<\/jats:sup>\n                    ), which have enhanced associative long-term depression at the parallel fiber-Purkinje cell synapses in the cerebellum (PF-Purkinje cell LTD). Here, we extend this work by testing predictions of the threshold metaplasticity hypothesis in a second mouse line with enhanced PF-Purkinje cell LTD, the\n                    <jats:italic>Fmr1<\/jats:italic>\n                    knockout mouse model of Fragile X syndrome (FXS). Mice lacking\n                    <jats:italic>Fmr1<\/jats:italic>\n                    gene expression in cerebellar Purkinje cells (L7-\n                    <jats:italic>Fmr1<\/jats:italic>\n                    KO) were selectively impaired on two oculomotor learning tasks in which PF-Purkinje cell LTD has been implicated, with no impairment on LTD-independent oculomotor learning tasks. Consistent with the threshold metaplasticity hypothesis, behavioral pre-training designed to reverse LTD at the PF-Purkinje cell synapses eliminated the oculomotor learning deficit in the L7-\n                    <jats:italic>Fmr1<\/jats:italic>\n                    KO mice, as previously reported in MHCI K\n                    <jats:sup>b<\/jats:sup>\n                    D\n                    <jats:sup>b\u2212\/\u2212<\/jats:sup>\n                    mice. In addition, diazepam treatment to suppress neural activity and thereby limit the induction of associative LTD during the pre-training period also eliminated the learning deficits in L7-\n                    <jats:italic>Fmr1<\/jats:italic>\n                    KO mice. These results support the hypothesis that cerebellar LTD-dependent learning is governed by an experience-dependent sliding threshold for plasticity. An increased threshold for LTD in response to elevated neural activity would tend to oppose firing rate stability, but could serve to stabilize synaptic weights and recently acquired memories. The metaplasticity perspective could inform the development of new clinical approaches for addressing learning impairments in autism and other disorders of the nervous system.\n                  <\/jats:p>","DOI":"10.7554\/elife.92543","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T10:40:13Z","timestamp":1701772813000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.92543","source":"Crossref","is-referenced-by-count":4,"title":["Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-3699","authenticated-orcid":true,"given":"Amin MD","family":"Shakhawat","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurobiology, Stanford University","place":["Stanford, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Jacqueline G","family":"Foltz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurobiology, Stanford University","place":["Stanford, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Adam B","family":"Nance","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurobiology, Stanford University","place":["Stanford, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Jaydev","family":"Bhateja","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurobiology, Stanford University","place":["Stanford, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-747X","authenticated-orcid":true,"given":"Jennifer L","family":"Raymond","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00f54p054","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurobiology, Stanford University","place":["Stanford, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/s0166-2236(96)80018-x","type":"journal-article","article-title":"Metaplasticity: the plasticity of synaptic plasticity","volume":"19","author":"Abraham","year":"1996","journal-title":"Trends in Neurosciences"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2356","type":"journal-article","article-title":"Metaplasticity: tuning synapses and networks for plasticity","volume":"9","author":"Abraham","year":"2008","journal-title":"Nature Reviews. 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