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While hindlimb and diaphragm muscles of end-stage SOD1G93A (G93A) mice (a familial ALS mouse model) exhibit severe denervation and depletion of Pax7\n                    <jats:sup>+<\/jats:sup>\n                    satellite cells (SCs), we found that the pool of SCs and the integrity of neuromuscular junctions (NMJs) are maintained in EOMs. In cell sorting profiles, SCs derived from hindlimb and diaphragm muscles of G93A mice exhibit denervation-related activation, whereas SCs from EOMs of G93A mice display spontaneous (non-denervation-related) activation, similar to SCs from wild-type mice. Specifically, cultured EOM SCs contain more abundant transcripts of axon guidance molecules, including\n                    <jats:italic>Cxcl12<\/jats:italic>\n                    , along with more sustainable renewability than the diaphragm and hindlimb counterparts under differentiation pressure. In neuromuscular co-culture assays, AAV-delivery of\n                    <jats:italic>Cxcl12<\/jats:italic>\n                    to G93A-hindlimb SC-derived myotubes enhances motor neuron axon extension and innervation, recapitulating the innervation capacity of EOM SC-derived myotubes. G93A mice fed with sodium butyrate (NaBu) supplementation exhibited less NMJ loss in hindlimb and diaphragm muscles. Additionally, SCs derived from G93A hindlimb and diaphragm muscles displayed elevated expression of\n                    <jats:italic>Cxcl12<\/jats:italic>\n                    and improved renewability following NaBu treatment in vitro. Thus, the NaBu-induced transcriptomic changes resembling the patterns of EOM SCs may contribute to the beneficial effects observed in G93A mice. More broadly, the distinct transcriptomic profile of EOM SCs may offer novel therapeutic targets to slow progressive neuromuscular functional decay in ALS and provide possible \u2018response biomarkers\u2019 in pre-clinical and clinical studies.\n                  <\/jats:p>","DOI":"10.7554\/elife.92644","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T09:33:56Z","timestamp":1699004036000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.92644","source":"Crossref","is-referenced-by-count":0,"title":["Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice"],"prefix":"10.7554","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-4702","authenticated-orcid":true,"given":"Ang","family":"Li","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019kgqr73","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Kinesiology, 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