{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:42:15Z","timestamp":1787568135469,"version":"build-2736575974"},"reference-count":98,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007183","name":"University of California, Santa Barbara","doi-asserted-by":"publisher","award":["Academic Senate"],"award-info":[{"award-number":["Academic Senate"]}],"id":[{"id":"10.13039\/100007183","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Animals, including humans, rely on contextual information to interpret ambiguous stimuli. Impaired context processing is a hallmark of several neuropsychiatric disorders, including schizophrenia, autism spectrum disorders, post-traumatic stress disorder, and addiction. While sex differences in the prevalence and manifestations of these disorders are well established, potential sex differences in context processing remain uncertain. Here, we examined sex differences in the contextual control over cue-evoked reward seeking and its neural correlates, in rats. Male and female rats were trained in a bidirectional occasion-setting preparation in which the validity of two auditory reward-predictive cues was informed by the presence, or absence, of a visual contextual feature (LIGHT: X+\/DARK: X\u2212\/LIGHT: Y\u2212\/DARK: Y+). Females were significantly slower to acquire contextual control over cue-evoked reward seeking. However, once established, the contextual control over behavior was more robust in female rats; it showed less within-session variability (less influence of prior reward) and greater resistance to acute stress. This superior contextual control achieved by females was accompanied by an increased activation of the orbitofrontal cortex (OFC) compared to males. Critically, these behavioral and neural sex differences were specific to the contextual modulation process and not observed in simple, context-independent, reward prediction tasks. These results indicate a sex-biased trade-off between the speed of acquisition and the robustness of performance in the contextual modulation of cued reward seeking. The different distribution of sexes along the fast learning \u2194 steady performance continuum might reflect different levels of engagement of the OFC, and might have implications for our understanding of sex differences in psychiatric disorders.<\/jats:p>","DOI":"10.7554\/elife.93509","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T09:48:19Z","timestamp":1702374499000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.93509","source":"Crossref","is-referenced-by-count":4,"title":["Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction"],"prefix":"10.7554","volume":"12","author":[{"given":"Sophie","family":"Peterson","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02t274463","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychological & Brain Sciences, University of California, Santa Barbara","place":["Santa Barbara, United 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