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Mutations in the\n                    <jats:italic>CABP2<\/jats:italic>\n                    gene underlie non-syndromic autosomal recessive hearing loss DFNB93. Besides CaBP2, the structurally related CaBP1 is highly abundant in the IHCs. Here, we investigated how the two CaBPs cooperatively regulate IHC synaptic function. In\n                    <jats:italic>Cabp1\/2<\/jats:italic>\n                    double-knockout mice, we find strongly enhanced Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.3 inactivation, slowed recovery from inactivation and impaired sustained exocytosis. Already mild IHC activation further reduces the availability of channels to trigger synaptic transmission and may effectively silence synapses. Spontaneous and sound-evoked responses of spiral ganglion neurons in vivo are strikingly reduced and strongly depend on stimulation rates. Transgenic expression of CaBP2 leads to substantial recovery of IHC synaptic function and hearing sensitivity. We conclude that CaBP1 and 2 act together to suppress voltage- and calcium-dependent inactivation of IHC Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.3 channels in order to support sufficient rate of exocytosis and enable fast, temporally precise and indefatigable sound encoding.\n                  <\/jats:p>","DOI":"10.7554\/elife.93646","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T15:25:05Z","timestamp":1705505105000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.93646","source":"Crossref","is-referenced-by-count":5,"title":["CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair 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