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Therefore, developing an antifungal vaccine is a priority. Here, we could for the first time successfully attenuate the virulence of\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    by treating it with a fungistatic dosage of EDTA and demonstrate it to be a potential live whole cell vaccine by using murine models of systemic candidiasis. EDTA inhibited the growth and biofilm formation of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . RNA-seq analyses of EDTA-treated cells (CAET) revealed that genes mostly involved in metal homeostasis and ribosome biogenesis were up- and down-regulated, respectively. Consequently, a bulky cell wall with elevated levels of mannan and \u03b2-glucan, and reduced levels of total monosomes and polysomes were observed. CAET was eliminated faster than the untreated strain (\n                    <jats:italic>Ca<\/jats:italic>\n                    ) as found by differential fungal burden in the vital organs of the mice. Higher monocytes, granulocytes, and platelet counts were detected in\n                    <jats:italic>Ca- vs<\/jats:italic>\n                    CAET-challenged mice. While hyper-inflammation and immunosuppression caused the killing of\n                    <jats:italic>Ca<\/jats:italic>\n                    -challenged mice, a critical balance of pro- and anti-inflammatory cytokines-mediated immune responses are the likely reasons for the protective immunity in CAET-infected mice.\n                  <\/jats:p>","DOI":"10.7554\/elife.93760","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T10:25:10Z","timestamp":1707301510000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.93760","source":"Crossref","is-referenced-by-count":2,"title":["A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development"],"prefix":"10.7554","volume":"13","author":[{"given":"Swagata","family":"Bose","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02927dx12","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of 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